Mathepan Mahendralingam

MD/PhD candidate @uoftmdphd | Researching childhood cancers | Genomics, Writing & Donut enthusiast | Learning and Unlearning

[Mathepan Mahendralingam @mathepan]

4yrs ago,@rmkhokha asked me to study the #metabolism of normal mammary epithelial cells for my MSc. Today, I share with you my 1st first-author pub in @NatMetabolism (https://t.co/C2H0uGzWB8).Below a thread on how studying normal cells helps us better understand #breastcancer. /1

[Hater Report @HaterReport]

WEMBY JUST DROPPED A BAR:

"The lack of experience is a strength of us...because we could do impossible stuff because we don't know it's impossible" 🥶

(h/t @ohnohedidnt24)

[Armaan Fallahi @circuitfreud]

@uoftmdphd @KarlDeisseroth @mathepan @kao_jenn Thank you @KarlDeisseroth! Getting a glimpse into your thinking process and philosophy behind your writing was very inspiring. It encourages us to work with vigour, treat with humanity, and reflectively express ourselves.

[Mathepan Mahendralingam @mathepan]

5yrs later, our 2nd @uoftmdphd bookclub ft @KarlDeisseroth! @kao_jenn and I asked KD how to write for papers and for prose. We revisited Projections and students shared their writing. Thank you Karl for your mentorship of physician-scientists & reminding us of the power of words

[Jenn Kao @kao_jenn]

Today’s talk hosted @uoftmdphd and moderated by @mathepan and I, once again proved @KarlDeisseroth as a pioneer - this time, in bridging the gap between basic science, psychiatry, and literature. (1/4)

[Gaurav Agarwal @GauravA_UK]

What protects some people from leukemia?

Thrilled to share work from the @bloodgenes lab, now published in @Science.
We identify an inherited genetic variant that protects stem cells from blood cancers by reducing risk of CHIP.
https://t.co/ExgWIJQe6y

🧵👇 (1/n)

[Vijay Sankaran @bloodgenes]

How did the devastation of the atomic bombings 80 years ago ultimately help give rise to bone marrow transplantation and modern #stemcell biology? Our historical commentary with @JGudera in @NatureCellBio explores these unappreciated connections: https://t.co/ppif5jQhbW

[Veera Rajagopal  @doctorveera]

This went live today, on Thanksgiving, which feels quietly special.

This article is about one of my favorite topics: how human genetics is being used to shape drug development. It’s a synthesis of ideas and lessons that have emerged over many years, brought together into a single narrative.

I’m grateful for the opportunity to give structure to these thoughts — and excited about where human genetics–driven drug development is headed next. The future here feels genuinely promising.

Many thanks to the editors at @WorksInProgMag — @bswud and @salonium — for the opportunity and for helping edit this article into its best possible version.

Hope you enjoy this light read on Thanksgiving Day :)

🧬 Nature’s laboratory
https://t.co/X9Z2joGLgv

[Petter Brodin @BrodinPetter]

The separation of immunodeficiency and rheumatology is a relic of history in modern medicine. It is all immunology in the end - Excellent new reminder by Megan Cooper & Joshua Tobin @jhumimmunity https://t.co/qQ34gKtrxz

[Mathepan Mahendralingam @mathepan]

@mmaaz_98 I think you're confusing Python with Pickleball

[Mathepan Mahendralingam @mathepan]

After years of trying to convince Maaz not to drop out of the MD/PhD program, I’ve accepted that math is his singular passion

All the best at @AnthropicAI ! Claude Maaz 5.1 coming soon to a browser near you 👀🖥️

[Maaz @mmaaz_98]

After a gruelling 3hrs, I successfully defended my PhD today.

I finished my PhD in 3 years (a record in my department).

[Maaz @mmaaz_98]

After a gruelling 3hrs, I successfully defended my PhD today.

I finished my PhD in 3 years (a record in my department).

[Vincent Graziano @VinnieViruses]

Hi everybody! I am super excited to share the work done during my PhD published in @nature today! We describe a new mechanism of self- vs. non-self RNA discrimination by showing how N-glycans shield glycoRNAs from stimulating endosomal RNA sensors https://t.co/7hzGDPjvMU

[Mathepan Mahendralingam @mathepan]

Wild that the same autoantibodies to IFN-I found in life-threatening COVID-19...might actually improve response to checkpoint immunotherapy 🤯

[Aaron Ring @aaronmring]

T cells do the heavy lifting when it comes to the anti-tumor action of checkpoint immunotherapy. But do antibodies play a role too?

That’s the question @yile_dai looked to answer in his thesis work, out today in @Nature! 🧵below

https://t.co/VgTByRKRCX

[Jake June-Koo Lee @jakelee0711]

Today marks a meaningful milestone -- I am starting as a lab investigator @CompOncMSK and thoracic oncologist @MSK_DeptOfMed, focused on improving treatment through a deep understanding of cancer evolution. I'll soon be looking for fellow travelers on this mission. Stay tuned!

[andre nussenzweig lab @nussenza]

Cytarabine has been the mainstay for AML treatment. This chemotherapy can lead to problems with movement and balance. Here we explain this neurotoxic side effect: https://t.co/1AvK5l8CD0. Work led by Jia-Cheng Liu, Donpgeng Wang, Elsa Callen and many terrific collaborators!

[Mathepan Mahendralingam @mathepan]

The "Peer Review File" is an incredible resource for students to learn the type of questions reviewers may ask and also how scientists structure and write their response to reviewers!

[nature @Nature]

From today, all new submissions to Nature that are published will be accompanied by referees’ reports and author responses — to illuminate the process of producing rigorous science

https://t.co/Fua3YQ8XPt

[Asimov Press @AsimovPress]

We've been working on this resource for months: A VISUAL GUIDE TO GENOME EDITORS.

Learn how tools like Cas9, Cas13, prime editors, and Bridge editors work - with diagrams!

We hope this becomes a valuable resource for the biology community and students.

[Karl Deisseroth @KarlDeisseroth]

Congratulations to our Human Neural Circuitry team; https://t.co/aGD7OacNs8 publishes today in Science! This was the hardest challenge of my career, but one of the most rewarding, after years of rebuilding– & for myself, expanding my inpatient neuropsychiatry work to the service of basic discovery:
https://t.co/4czK1YK2YV

I’m grateful for the opportunity to work with the amazing lead authors Isaac Kauvar @ikauvar, Ethan Richman, and Tony Liu @liutony66, and with equally brilliant faculty colleagues in our HNC program: Carolyn Rodriguez @CRodriguezMDPhD, Paul Nuyujukian, and Vivek Buch @VivekBuchMD, along with many other key collaborators spanning hospital and laboratory. https://t.co/qohlvNuQYF

[Mathepan Mahendralingam @mathepan]

@mmaaz_98 I thought it was 2+2=5

[Children's Hospital @ChildrensPhila]

CHOP & @PennMedicine have delivered the first-ever personalized gene editing therapy for a patient with CPS1 deficiency, marking a major milestone in the application of CRISPR-based treatments.

Learn more about KJ & the future of personalized medicine: https://t.co/A9DTcNmxrR.

[Cohesin @Xieeee4]

How does heart failure rewire gene regulation? 🔍 Excited to share our single-cell, multimodal epigenomic resource on human heart failure🫀: https://t.co/LG7mrr7x7c.