Marwan Abid Althagafi مروان عابدالثقفي

Postdoctoral Fellow, University Health network, University of Toronto, Atherosclerosis, Vascular Endothelial Cell biology, CVD

[Marwan Abid Althagafi مروان عابدالثقفي @abid_marwan]

8 years of work. Finally published.

Our paper in @CircRes shows that arterial resident—but not monocyte-derived—macrophages require endothelial CSF1.

Grateful to everyone who made this journey possible. @UHN @UofT_LMP

🔗 https://t.co/63AVaht78l

#atherosclerosis

[Circulation Research @CircRes]

Althagafi et al found #CSF1 produced by luminal #ECs sustain tissue-resident, but not monocyte-derived #macrophages in the inner wall of the normal artery & in early #atherosclerotic lesions. Learn more at https://t.co/QoOHQlC3Ez
@abid_marwan @CoreyScipione @epelmanlab

[Marwan Abid Althagafi مروان عابدالثقفي @abid_marwan]

I am glad to see our work out @MyronCybulsky lab and in the cover page of November Issue

[Circulation Research @CircRes]

@CircRes Nov 6th Issue is Out! https://t.co/IiX6g6rOKd

Cover: IHC of tissue-resident macrophages with dendritic morphology & minimal lipid content at periphery of an atherosclerotic AA, while monocyte-derived macrophages clustered in the lesion are lipid-loaded; nuclei-blue.

[Marwan Abid Althagafi مروان عابدالثقفي @abid_marwan]

4/4 — Perhaps the most interesting finding:

During early atherosclerosis, tissue resident (TR) & monocyte-derived macrophages behave differently.

TRM depend strongly on CSF1.

Monocyte-derived macrophages do not.

Same lesion & broad cell type. Different biological dependencies

[Marwan Abid Althagafi مروان عابدالثقفي @abid_marwan]

8 years of work. Finally published.

Our paper in @CircRes shows that arterial resident—but not monocyte-derived—macrophages require endothelial CSF1.

Grateful to everyone who made this journey possible. @UHN @UofT_LMP

🔗 https://t.co/63AVaht78l

#atherosclerosis

[Marwan Abid Althagafi مروان عابدالثقفي @abid_marwan]

3/4 — What is CSF1 actually doing?

Our experiments suggest CSF1 helps maintain intimal resident macrophages primarily through proliferation and retention, rather than simply preventing cell death.

A niche does more than keep cells alive—it helps keep them where they belong.

[Marwan Abid Althagafi مروان عابدالثقفي @abid_marwan]

2/4 — Same artery. Different neighborhoods.

Intimal and adventitial macrophages rely on different sources of CSF1:

→ Intima: endothelial cells
→ Adventitia: PDGFRβ+ mesenchymal cells

The local microenvironment matters.

[Marwan Abid Althagafi مروان عابدالثقفي @abid_marwan]

1/4 — Location matters.

In the mouse artery, tissue-resident macrophages in the intima depend on CSF1 produced by endothelial cells to maintain their population.

The endothelium is not simply a barrier—it helps create the macrophage niche.

[Marwan Abid Althagafi مروان عابدالثقفي @abid_marwan]

@molecularpepsi @CircRes @UHN @UofT_LMP Thanks ahamd

[Marwan Abid Althagafi مروان عابدالثقفي @abid_marwan]

@Homaira_H @CircRes @UHN @UofT_LMP Thanks Homaira for your support as well throughout these years, 🙏

[Marwan Abid Althagafi مروان عابدالثقفي @abid_marwan]

@MacparlandSonya @DianaNakib Well deserved, congratulations to both dr. @DianaNakib and dr. Wood

[Marwan Abid Althagafi مروان عابدالثقفي @abid_marwan]

@MacparlandSonya @DianaNakib @naglaa_shoukry @PSCPartnersCa @nkg2d1 @BuechlerLab @DrAGehring @garybader1 Congratulations @DianaNakib, excellent work. All the best

[Marwan Abid Althagafi مروان عابدالثقفي @abid_marwan]

@FishLab_UHN @UHN_Research @UofT_LMP @PMunkCardiacCtr Congratulations, well deserved 👌

[Marwan Abid Althagafi مروان عابدالثقفي @abid_marwan]

@AhwalKSA @AhwalCare سلام عليكم، هل هذه قائمة الأسماء الممنوعه، لأنى لم اجد اى قائمه في الموقع الرسمي للأحوال المدنيه.

السؤال هل يمكن ان أسمى بنتي بإسم "مَلَك"؟. أرجو الإفاده وشكرا

[Kathryn Howe @kat_howe]

Beautiful work from ⁦@MyronCybulsky⁩ lab. Hisham delivered an elegant presentation today at #IVBM2024! Congrats Hisham ⁦@TGHRI_UHN⁩ ⁦@UofT⁩

[Katey Rayner @KateyRayner]

When Adil joined the lab, little did we know his project would take us on a wild ride that would teach us that spleen ECs are so *so* important for lipid-induced atherosclerotic progression. Check out his study in @NatureCVR 🤩🤩 Can’t wait to see what he does next in Augusta!

[Marwan Abid Althagafi مروان عابدالثقفي @abid_marwan]

@EpelmanLab @Homaira_H Congratulations, looking forward to read it 👌

[Marwan Abid Althagafi مروان عابدالثقفي @abid_marwan]

@HeartInstitute @KateyRayner Congratulations @KateyRayner

[ATVB: An AHA Journal @atvbahajournals]

Plasma S1P orchestrates reverse transendothelial migration of aortic intimal myeloid cells: further insights into how
circulating mediators impact intimal cell dynamics in health & inflammation @CoreyScipione @abid_marwan
@chanelekpolenz
https://t.co/nx3K8DZm0R

[Marwan Abid Althagafi مروان عابدالثقفي @abid_marwan]

@chanelekpolenz @UofT_LMP Congratulations 🎉

[Marwan Abid Althagafi مروان عابدالثقفي @abid_marwan]

@adilrasheed88 Congratulations Adil 👌