HIV Interactions in Viral Evolution Center

Characterizing at the atomic level the structural and dynamic relationships between interacting macromolecules in the HIV life cycle

[David S. Goodsell 🏳️‍🌈 @dsgoodsell]

Found some time this morning to finish up the influenza vaccine painting. Recombinant vaccine in red, interacting with B-cell receptors and triggering a flurry of signaling inside the cell. #sciart

[David S. Goodsell 🏳️‍🌈 @dsgoodsell]

Take a look! Julia Jimenez did a summer internship in the lab a while back, working on different ways to model and visualize exosomes. The paper is out in Journal of Biocommunication.

[Ribosome Studio @RibosomeStudio]

CellPAINT is great. Crank up the temperature slider for extra fun...
@grinche @dsgoodsell

[David S. Goodsell 🏳️‍🌈 @dsgoodsell]

Just put the finishing touches on the December Molecule of the Month--this should be an easy one to guess. The full article will be available early December on the RCSB site (@buildmodels)

[Scripps Research @scrippsresearch]

"Those who know Sharpless say it sums up his uncanny ability to know how molecules will behave and how he can get them to do his bidding." @cenmag profile of Prof. Barry Sharpless. https://t.co/iP8ts789p4

[Kellie Ann Jurado @kelliejurado]

I am super excited to share that this summer I am going to be starting as a TT Assistant Professor in the Microbiology Department @Penn! So blessed for the mentorship & support from my family, academic family, friends who are family & lab members who are life long friends!

[ForliLab @ForliLab]

Our exciting collaboration with the Wolan @denniswolan and Sharpless @scrippsresearch Labs is on @ChemRxiv!

[Paul Bieniasz @PaulBieniasz]

Roses are red
Violets are blue
You are 8% virus
And 11% Alu

#AcademicValentine

[Dmitry Lyumkis @DmitryLyumkis]

@mcianfro HIV intasomes (complexes of Integrase & DNA) are like this. Aggregate immediately at <500 mM salt. We need 800 mM salt + 5% glycerol to keep them happy! Now we have structures with small molecules at ~3A (+ needed to tilt to 40-deg for this pathologically behaved sample!) 😱

[Kotaro Nakanishi @ktr_nakanishi]

Cute! Valentine's Day gift from your macromolecule:-)

[Andrew Routh @AndrewRouth]

Interested in using #ClickSeq? @ElaJaworski and I have started an NGS service company @clickseqtech. We'll be up in Houston for the next few days doing market research. Find us at https://t.co/Bxpw9VUegW for more info.

[Jen Heemstra @jenheemstra]

Beware of the “bystander effect” when asking for help. If you need feedback on a manuscript, don’t email everyone in the lab - they will assume someone else will help and that they don’t need to. Ask individually and tell each person why their feedback is especially valuable.

[Dmitry Lyumkis @DmitryLyumkis]

Venki was invited to do a post doc in Tom Steitz's lab in the 1970s! ... Do polar bears really hibernate and induce crystalline ribosome packing? ... A fun read through a lifetime of a ribosome research, with plenty of curious personal anecdotes

[HIV Interactions in Viral Evolution Center @Welcome2theHIVE]

Proud brother of @francesarnold talking at the HIVE annual meeting.

[HIV Interactions in Viral Evolution Center @Welcome2theHIVE]

HIVE face to face conference in La Jolla. I’ve been warned not to photograph the presented slides.

[HIV Interactions in Viral Evolution Center @Welcome2theHIVE]

Great work from HIVE collaborators on using Ribosome display for structural determination of small RNAs

[Will Cantara @ribo_doc]

Our paper is out in Ultramicroscopy. This was a great collaboration with @DmitryLyumkis laboratory @salkinstitute.

https://t.co/ANViPsfAau

[Richard H. Ebright @R_H_Ebright]

#Preprint posted at ChemRxiv 10/16/18.
Manuscript submitted to (solicited by?) journal 10/16/18.
Paper published by journal 11/02/18.

The CryoEM Method MicroED as a Powerful Tool for Small Molecule Structure Determination https://t.co/3CbV04bNeZ

[HIV Interactions in Viral Evolution Center @Welcome2theHIVE]

A great virology teaching resource from Vincent Racaniello

[MicrobeTV @profvrr]

My plea yesterday to subscribe to our YouTube channel (https://t.co/kIrTAoR98R) so that we can apply for a grant to support it - got us 500 new subscribers. Thanks! To my science colleagues who have not subscribed - who know who you are - what's the problem? It's free.

[Amelie Stein @_amelie_rocks]

👇very interesting tweetstorm for anyone dealing with structures & modelling