Wennerberg Lab

#UCPH_BRIC

[Emmy Verschuren @emmyverschuren]

Great to see the work by talented @SarangTalwelkar in collaboration with @WennerbergLab now in press. Biggest thanks to all the funders, particularly @SuomenAkatemia and @HiLIFE_helsinki HIPOC. @FIMM_UH

[Wennerberg Lab @WennerbergLab]

We would also like to thank all of our great collaborators, our funding and all of the #ovariancancer patients who kindly agreed to provide the tissue for the study. (3/3) @AnnaVaharautio @Sampsa_H @mijohy @matiasmfalco @KariLavikka @KaisaHuhtinen @OlliCarpen

[Wennerberg Lab @WennerbergLab]

We’re very happy to see our work developing what we think is a new state-of-the-art approach to develop high-grade serous ovarian cancer organoids now out in Developmental Cell. The efforts were brilliantly driven by @wojtsen with the support of many great collaborators. (1/3)

[Developmental Cell @Dev_Cell]

Online now: A platform for efficient establishment and drug-response profiling of high-grade serous ovarian cancer organoids https://t.co/GfzhnFDhpa

[Wennerberg Lab @WennerbergLab]

Here’s the thread describing the results of the work, from when we published it as a preprint: (2/3)

[Wennerberg Lab @WennerbergLab]

❓Why is it important to design new methods for #organoid culture?
❓How much should we validate our experimental models?
❓What about correlating #organoid drug responses to patient outcomes?

A🧵on the results in our newest preprint on high-grade #OvCa organoids⬇️
(1/n)

[@ERAPerMedPARIS @erapermedparis]

Nice work by the @WennerbergLab: A platform for efficient establishment and drug-response profiling of high-grade serous #ovariancancer @wojtsen @AnnaVaharautio organoids https://t.co/6JxjjSApdq

[Sampsa Hautaniemi @Sampsa_H]

Out in @Dev_cell: Massive effort by @wojtsen from @WennerbergLab led to >50% success rate in #organoids growing in #OvarianCancer. Genomics and #scrnaseq data show close resemblance to tumors. Glad to be a part of this study. @deciderproject in action 💪
https://t.co/D4cx6vTKRU

[Wennerberg Lab @WennerbergLab]

For those at #AACR2023, @wojtsen will present some exciting HGSC organoid data. Starts at 16:07 local time. #FPMatAACR23 #HGSC #ovariancancer #organoids

[The Society for Functional Precision Medicine @TheSFPM]

Don't miss this important session today on Novel Targets, Biomarkers, and Models for Cancer, with a presentation by @wojtsen, info below!
#FPMatAACR23 #AACR23

[The Society for Functional Precision Medicine @TheSFPM]

The Minisymposium on Novel Targets, Biomarkers, and Models for Cancer (MS.TB05.01) will include a talk from @wojtsen on an ovarian cancer organoid-based platform for patient stratification
When: April 18, 2023, 2:30 PM - 4:30 PM
Where: Room W304 A-D
https://t.co/wwnTbh1qiN

[Wennerberg Lab @WennerbergLab]

We’re looking forward to another day of discussions and planning for the second half of the project today!

[Line Bjørge @DrLB]

Midterm evaluation meeting for the PARIS (Precision drugs Against Resistance In Subpopulations) project - On the way to Institute Pasteur campus. #ovariancancer @bennos @AnnaVaharautio @WennerbergLab @erapermedparis @Gynkreft @reachoutinova @PrecosL @haukeland_no @medofak_uib

[Wennerberg Lab @WennerbergLab]

@afarkkila @ronny_drapkin @kristerwennberg @Cancerfonden @karolinskainst An outstanding meeting so far. Eagerly anticipating day 2, including a presentation by @afarkkila!

[Wennerberg Lab @WennerbergLab]

“Giantly” inspired by being part of a winning team at the @OvaCure_COCT Innovation Challenge 2022! #OvCa @rottapel, @regenberg_lab, @AnilSoodMD, Jinsong Liu,@wvdriel, Marie Krarup, @m_boegsted

[Wennerberg Lab @WennerbergLab]

A great symposium that unfortunately was over much too fast. Next time I’m Copenhagen!

[HRUH hematology @hruh_research]

Functional precision medicine for blood cancer symposium ongoing in Helsinki @HelsinkiUniMed @EHA_Hematology @iCAN_Finland https://t.co/nLzGCN9HSZ Great speakers and presentations, keynote talk by @RaviMajetiMD @majetilab

[High-Content CRISPR Screens @UCPH_BRIC_HCCS]

It's that time of the year again! The DHL relay 2022! Great team effort and thanks for a good time! @WennerbergLab @UCPH_BRIC #DHLstafetten

[Wennerberg Lab @WennerbergLab]

Summer vacation times are coming and it’s also time to think about what to do after the summer. There’s a position open in the BRIC high content CRISPR screens core facility! https://t.co/U2EdpyYxBl

[Wennerberg Lab @WennerbergLab]

This should be an outstanding meeting. Very much looking forward to it!

[Wojciech Senkowski @wojtsen]

Excited to give a talk at Corning’s 3D Cell Culture Day tomorrow :).

[Wennerberg Lab @WennerbergLab]

This time we are looking for candidates too!

[Line Bjørge @DrLB]

#WorldOvarianCancerDay

[Wennerberg Lab @WennerbergLab]

For more details, check out the preprint!

PS. Some organoid cultures will soon be available to everyone through @AuriaBiopankki biobank!
(The end)

[Wennerberg Lab @WennerbergLab]

❓Why is it important to design new methods for #organoid culture?
❓How much should we validate our experimental models?
❓What about correlating #organoid drug responses to patient outcomes?

A🧵on the results in our newest preprint on high-grade #OvCa organoids⬇️
(1/n)

[Wennerberg Lab @WennerbergLab]

Our next-gen method for generating #organoids from high-grade serous #OvCa is now available on @biorxivpreprint. Genetically and phenotypically relevant stable organoids from cryopreserved material. Great effort led by @wojtsen. https://t.co/wcfq4DMNJu

[Wennerberg Lab @WennerbergLab]

Finally, limitations of the work:
1. We still don't know how to grow 45% of HGSC samples as organoids in a long-term. Probably a 3rd medium will be needed🤷
2. More extensive in vitro/in vivo drug response correlation study is needed for #precisionmedicine applications
(15/n)