أحمد

@WhoTheLEE

Hematologist | صنتُ نفسي عما يدنس نفسي .... وَتَرَفَّعتُ عَن جَدا كُلِّ جِبسِ

Jeddah

Joined July 2011

482 Following

241 Followers

6.8K Posts

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أحمد @WhoTheLEE

almost 6 years ago

WhoTheLEE's tweet photo. https://t.co/LdqopBzBoV

WhoTheLEE retweeted

Henry C Fung| MM, lymphoma, leukemia & CART

@HenrychihangFu1

2 months ago

Leukemia classification has evolved. Morphology → risk → genetics. Each step brought us closer to biology. But genetics alone is not enough. KMT2A-rearranged leukemia NPM1-mutated AML Different mutations. Same biology: HOXA9 / MEIS1 activation driven by the menin–KMT2A complex. This is why both respond to menin inhibitors. The next step? 👉 Biology-based classification Menin-dependent leukemia ~6,000–8,000 cases/year in the U.S. (~25–35% of AML + subset of ALL) Different mutations. Same addiction. Dr Fun + G #AML #Hematology #PrecisionOncology #Hemetwitter

HenrychihangFu1's tweet photo. Leukemia classification has evolved.

Morphology → risk → genetics.

Each step brought us closer to biology.

But genetics alone is not enough.

KMT2A-rearranged leukemia
NPM1-mutated AML

Different mutations.

Same biology:
HOXA9 / MEIS1 activation driven by the menin–KMT2A complex.

This is why both respond to menin inhibitors.

The next step?

👉 Biology-based classification

Menin-dependent leukemia

~6,000–8,000 cases/year in the U.S.
(~25–35% of AML + subset of ALL)

Different mutations. Same addiction.

Dr Fun + G

#AML #Hematology #PrecisionOncology #Hemetwitter

131

أحمد @WhoTheLEE

3 months ago

@ad2th عيد رأس السنة الفارسية، وتغنت به العرب كثيرا في أشعارها، المتنبى قال: جاءَ نَيروزُنا وَأَنتَ مُرادُه وَوَرَت بِالَّذي أَرادَ زِنادُه هَذِهِ النَظرَةُ الَّتي نالَها مِنــكَ إِلى مِثلِها مِنَ الحَولِ زادُه

278

أحمد @WhoTheLEE

3 months ago

ِهالسنة تصادف عيد الفطر مع النيروز فتذكرت هذه الأبيات: إقبالُ عامٍ بشكر الخير مقبول عيدُ الأمير بعيد البرِّ موصولُ يوم العَرُوبة والنَّيروز قد جُمِعا فاليومُ يومٌ له تاجٌ وإكليل