Women in TPD & Induced Proximity

[Lauren Albrecht @TheAlbrecht_Lab]

Honored to have our latest MrTAC research article featured on the Cover of Cell Chem. Here, we develop the first endogenous MrTAC and decode the rules of protein degradability, expanding tissue-specific degrader modalities.

[Women in TPD & Induced Proximity @WomenInTPD]

@TheAlbrecht_Lab @uclachem @conway_group Congratulations!!!

[Woo Lab @thewoolab]

Pour a glass of champagne AND red Bordeaux—Our newest work with @GSK and @scrippsresearch is out in @Nature, where we describe SB-405483, the first allosteric CRBN ligand which potentiates neosubstrate degradation. Congrats Vanessa and all authors! 🍷💫💐
https://t.co/MLj3VOgsOq

[Women in TPD & Induced Proximity @WomenInTPD]

@thewoolab She is so inspiring! Congratulations Dr. Woo on this well-deserved grant award.

[Woo Lab @thewoolab]

She’s our greatest star of all! ⭐️ Big big congratulations to our boss 🫡

[Women in TPD & Induced Proximity @WomenInTPD]

Congratulations to Dr. @nurkocaturk on being awarded a @WomenInTPD conference scholarship to attend the 8th Annual Hanson Wade TPD and Induced Proximity conference in Boston! 👏👏👏

[Women in TPD & Induced Proximity @WomenInTPD]

Fantastic panel and discussion last night including @kdonovan1008 (DFCI) and organized by Lori Friedman (ORIC) at the AACR-NCI-EORTC Town Hall on "The Promise of Molecular Glues in Cancer Treatment: Will it stick?"

[Women in TPD & Induced Proximity @WomenInTPD]

From the @bmsnews team co-led by Lynda Groocock and Deborah Mortensen comes the story of developing a BCL6 oral degrader with pM potency and excellent TGI. Fantastic work everyone!
https://t.co/FGsKw1tUjH

[Women in TPD & Induced Proximity @WomenInTPD]

What can you degrade if you bifunctionalize the CRBN binder to an agnostic chemical library? Turns out a lot of proteins! Read this fascinating work below led by the talented @InesForrest , Ph.D and colleagues at Scripps on their approach using AgnoTACs.
https://t.co/6GbyMmTJER

[Centre for Targeted Protein Degradation @UoDCeTPD]

The Aug-Sept Journal Club is ready!! Thanks to our amazing editors: @DeLaCuadraBaste, @_nicolamurdoch, Qinghzi, and Michael. If you are interested in the latest TPD literature, have a look!

https://t.co/aKKgSvEA9d

#openaccess #TPD #journalclub @UoDLifeSciences

[Women in TPD & Induced Proximity @WomenInTPD]

If you are in the Boston area at the end of October do not miss our free, in-person networking event on Wednesday, October 29th from 5:30-7:30pm! Thank you so much to @KymeraTx for hosting. Register below at this link:
https://t.co/CRsiyTcuUe

[Women in TPD & Induced Proximity @WomenInTPD]

Congratulations to the Woo lab on their new approach to gate activity using an O-GlcNac modification on the CRBN bifurcational!

[Woo Lab @thewoolab]

While a spoonful of sugar helps the medicine go down, glycosylated PROTACs are a nifty way to metabolically control PROTAC activity 🤩🟦🍬 Check out our newest work out now is @J_A_C_S 🫡 Congrats to Chace and all authors! 💐🎉🐱
https://t.co/d2mspTJVAD

[Woo Lab @thewoolab]

While a spoonful of sugar helps the medicine go down, glycosylated PROTACs are a nifty way to metabolically control PROTAC activity 🤩🟦🍬 Check out our newest work out now is @J_A_C_S 🫡 Congrats to Chace and all authors! 💐🎉🐱
https://t.co/d2mspTJVAD

[Women in TPD & Induced Proximity @WomenInTPD]

Congratulations to Selina Zhang @Selina_Zh_
who has been awarded one of our conference scholarships to attend the Lorne Ubiquitin Conference in Australia! Read more about her and the exciting doctoral work in ALS she is doing below. #WomenInTPD

[Centre for Targeted Protein Degradation @UoDCeTPD]

Pleased to share Dr Nur Kocaturk has been awarded a Cross-Sector Experience Award from @acmedsci

This funding will allow them to collaborate with Promega Corp to co-develop a new cellular ligand finding platform for intractable disease related proteins.

[Woo Lab @thewoolab]

Our evolved and engineered CRBN derivative used to enrich and visualise C-term cyclic imide-containing proteins, aka "Cerebody," is now live and in stereo in @CellChemBiol!🫡🎉💛 Congratulations to everyone behind this cool work! Huzzah! https://t.co/T1kENFksc6

[Women in TPD & Induced Proximity @WomenInTPD]

Congratulations to Kate Stuart, Rebecca Teague, and colleagues at PhoreMost on their work towards more rational design of molecular glues! Many ways to augment the surface and binding capabilities of E3 ligases.
https://t.co/EJS0ZYVLjw

[Women in TPD & Induced Proximity @WomenInTPD]

Improvement of a DCAF1 binder that can be applied to targeted protein degradation co-led by Serah Kimani, PhD at the SGC, University of Toronto. Congratulations!
Link below:
https://t.co/dORHHuyRN4

[Women in TPD & Induced Proximity @WomenInTPD]

Congratulations to @kdonovan1008 and colleagues at DFCI on their work uncovering numerous interactors of CRBN glues!

[Katherine A Donovan @kdonovan1008]

🧩 New paper out in Nature Communications!

"Unveiling the hidden interactome of CRBN molecular glues"
Huge thanks to our incredible team and collaborators who made this possible!
📖 Read the full open-access article here: https://t.co/iuTyDM24Vs

[Woo Lab @thewoolab]

We hope everyone is as in love with this cover as we are! 🤩