Xi Chen

Associate Professor & CPRIT scholar @MDAndersonNews studying stress responses in tumor microenvironment and anti-tumor immunity.

[Xi Chen @XiChenLab]

@RuggeroDavide @haognguyen @DuyguKuzuoglu Beautiful work! Congrats, Davide!

[Xi Chen @XiChenLab]

Many congratulations to @LV_Xiangdong who has been awarded the CPRIT scholar award to set up his own lab at @UTHealthHouston! He is amazing!

[CPRIT @CPRITTexas]

BREAKING NEWS: #CPRIT approved $89 million in grants to advance the state’s fight against cancer, including CPRIT Scholar recruitment awards, evidence-based prevention programs and innovative companies developing new cancer drugs and treatments. 

READ: https://t.co/IFXhYmGx3v

[Xi Chen @XiChenLab]

@JianXuLab Beautiful work! Congrats, Jian!

[Xi Chen @XiChenLab]

@JCubRuiz Beautiful work, congrats, Juan!

[Xi Chen @XiChenLab]

@JenWargoMD @theNAMedicine @MDAndersonNews Many congratulations, Jen! Well deserved.

[Jennifer Wargo MD @JenWargoMD]

Thank you @theNAMedicine @MDAndersonNews and all who contribute to our mission to #endcancer - patients and families, care teams, researchers and supporters worldwide. Honored to continue this important work together

[Xi Chen @XiChenLab]

@costas_koumenis Thanks very much, Costas!

[Xi Chen @XiChenLab]

Happy to share our latest work showing that an ancient ER-localized RNase IRE1 coordinates with p53 to silence taxane-induced dsRNA and protect immune-cold TNBC from pore-forming pyroptosis. ⁦@CellCellPress⁩ ⁦@MDAndersonNews⁩ https://t.co/GcJegUOXXs

[Xi Chen @XiChenLab]

@RuggeroDavide Many thanks, Davide!

[Xi Chen @XiChenLab]

@ACKoongMDPhD @MDAndersonNews Thank you, Albert!

[Xi Chen @XiChenLab]

@JCubRuiz Thank you, Juan!

[Xi Chen @XiChenLab]

@SGoswamiMDPhD Thank you, Sangeeta!

[Xi Chen @XiChenLab]

@Eric_Chevet Thanks, Eric!

[Xi Chen @XiChenLab]

Thanks #JPAI @JimAllisonPhD @PamSharmaMDPhD @DraettaG Rugang Zhang and @NCICancerBio for support!

[Xi Chen @XiChenLab]

@VanjaLazarevic5 Thank you, Vanja!

[Xi Chen @XiChenLab]

Kudos to the amazing trainees @LongyongX @FanglueP and all fantastic collaborators!

[Xi Chen @XiChenLab]

Inhibiting IRE1 RNase in TP53-mutant TNBC allows taxane to be highly immunogenic, triggering dsRNA-ZBP1-NLRP3-GSDMD pyroptotic signaling cascade, turning PD-L1-negative cold tumors hot, and conferring these cold tumors hypersensitivity to PD-1 inhibitor.

[Xi Chen @XiChenLab]

@SGoswamiMDPhD @DeblinaRC @RaiPratishtha @MDAndersonNews Congrats, Sangeeta!

[Xi Chen @XiChenLab]

@DavidHongMD Thank you, David!

[Xi Chen @XiChenLab]

@JeffMRosen Congrats, Jeff! So well deserved!