Xinru

Protein Designer, Biochemist| From computer to bench to bedside

[Andrew Favor @andrew_favor]

We are pleased to share our new preprint: “De novo design of RNA and nucleoprotein complexes”.
This work extends the principles of de novo protein design to RNA and DNA, enabling the generative design of complex multi-polymer structures! (1/6)
https://t.co/QPqpNZr0er

[Xinru @Xinru71]

@weinberz @EunheeChoi12 @XiaochenB @PreethamVi @UWproteindesign @EunheeChoi12 lab did the in vivo study. I believe that we didn’t observe any obvious immune response during the experiment.

[Xinru @Xinru71]

Now online: We created de novo insulin receptor agonists using computational protein design! @EunheeChoi12 @XiaochenB @PreethamVi @UWproteindesign #BakerLab https://t.co/4V7q4Lskjp

[Xinru @Xinru71]

@minkbaek @EunheeChoi12 @XiaochenB @PreethamVi @UWproteindesign Thank you!

[Institute for Protein Design @UWproteindesign]

Watch Nobel Laureate David Baker explain his life's work in under 9 minutes.

→ What is protein design?
→ What will it lead to?
→ What's next for David?

@UW @UWMedicine @HHMINEWS @NobelPrize #proteindesign
https://t.co/dqE6tCyJMj

[Xinru @Xinru71]

These agonists induce conformational changes in the insulin receptor and activate distinct cell downstream signaling effects, providing a different way to control glucose metabolism compared to insulin.

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

[Anastassia Vorobieva @AnastassiaVoro2]

Our nanopore design paper is now published! We developed computational methods to design de novo pores with custom size, conductance and shape. We hope the technology will advance a range of sensing applications. @structbiolbxl @VIBLifeSciences @_VIB_AI https://t.co/xGOmeVD6cP

[Xinru @Xinru71]

A stroke derailed my academic career. Now I’m getting back on track https://t.co/TPm5rjHNVx

[Xinru @Xinru71]

@wang_shunzhi @BWFUND Congratulations!

[bioRxiv @biorxivpreprint]

De Novo Design of Integrin α5β1 Modulating Proteins for Regenerative Medicine https://t.co/BLqTtz0lef #bioRxiv

[Thomas Schlichthaerle @schlichthaerle]

Now online: We developed novel oligomers and turned them into FGFR agonists via binder induced receptor clustering. #denovo_proteins https://t.co/J1a323wSih

[Xinru @Xinru71]

@Brixius_Simone Congratulations!

[Indrek Kalvet @ikalvet]

That's my designed protein on the cover of Science! Achievement unlocked!

[Science Magazine @ScienceMagazine]

Researchers in Science present a next-generation protein structure prediction and design tool, #RoseTTAFold All-Atom, that can accept a wide range of ligands and covalent amino acid modifications.

Learn more in this week's issue: https://t.co/PmmMUjxNaz

[Indrek Kalvet @ikalvet]

We are happy to introduce to the world a new family of de novo designed heme enzymes!
This work is the result of a wonderful collaboration between @UWproteindesign and @GreenGroupMIB ! (1/n)
https://t.co/IZM8Qnhvm9

[David Juergens @DaveJuergens]

We’re very happy to announce that our RFdiffusion manuscript is now on bioRxiv! A lot can change in a week - we’ve now tested over a thousand designs and there’s so much exciting new data! 🧵

[Lauren Kaori Gurley @LaurenKGurley]

BREAKING: 48K University of Calfornia TAs, postdocs & other student workers just walked off the job.

It's the largest strike in the US since 2019.

Many UC workers earn < $24k/yr. A PhD student I spoke to said they donate blood plasma to make ends meet.
https://t.co/RVI7e1xchT

[Amijai Saragovi @AmijaiSaragovi]

To cut a long story short, "Oxygen is important!". If you are interested in the long story, understanding T cell immunity under chronic oxygen restriction then ----> https://t.co/kzi5p10thZ

#COVID19 #COPD