🚨 New method alert!
@ShanghaiTechUni researchers report a method to differentiate #hPSCs into 3D #NeuralOrganoids that resemble peripheral sympathetic ganglia, producing both neurons and glial cells of the ganglia in a self-organized manner: https://t.co/WsMWKN2v47
Online Now! Human PSC-derived organoids model sympathetic ganglion development and its functional crosstalk with the heart https://t.co/kj8tcCM5FL #stemcells
3/4 These models can facilitate future research into human sympathetic ganglia and cardiac innervation, encompassing studies on regulatory factors, risk factors, and potential interventions.
2/4 We also developed a system to reconstruct functional connections between the human sympathetic ganglion and the heart, and found that inter-tissue crosstalk promote the development of both human sympathetic and cardiac tissues.
1/4 In this study, we achieved self-organized and enriched production of human sympathetic lineages in 3D culture. Sympathetic neurons and satellite glial cells were generated robustly and exhibited long-term structural and functional development.
ShanghaiTech University scientists describe the generation of 3D, neuromusculoskeletal tri-tissue #organoids from human #pluripotent stem cells through a co-development strategy. 🧫
🔗 Get the full story in @CellStemCell!
https://t.co/yE1vpIjX30
Online Now! Generation of self-organized neuromusculoskeletal tri-tissue organoids from human pluripotent stem cells https://t.co/aAzJmmuINm #stemcells
Excited to share that our recent research has been published in @CellStemCell. This study has achieved simultaneous production and self-organized development of human neural, muscular and skeletal tissues within individual organoids. https://t.co/fbTLQJlU3h
Our October issue is live! The cover features a story from @Yangfei_Lab making human medullary spinal trigeminal nucleus organoids, the information hub of the brain. Other highlights include a Review from @Marta_Shahbazi @vincentpasque on human development and embryo models, @leo_jwu on barriers to interspecies chimerism, @boroviak_lab comparing trophoblast stem cells across species, and more! https://t.co/YJGKEEZhUI
Wei Pang, Jinkui Zhu, and a team in the @Yangfei_Lab developed region-specific brain #organoids that recapitulate the development of the spinal trigeminal nucleus!
📌@CellStemCell: https://t.co/i5gDAZDEA4
🎧: https://t.co/lYVIeN5s58
Excited to share our latest research published in @CellStemCell . In this study, we generated human brain organoids resembling the medullary spinal trigeminal nucleus and developed a model to study the trigeminothalamic connections. https://t.co/jiv8GM6Imm
Great to attend #CSOrganoids2024 in person to talk about our most recent research progress. Thanks @CellSymposia @CellStemCell@Dev_Cell for organizing this fantastic event. It’s always a honor to meet and chat with great scientists in the field.
Still time to register and discuss “building human neural #organoids to model the brain and beyond” w/ speaker Yangfei Xiang, ShanghaiTech University, China @CellSymposia #CSOrganoids2024 https://t.co/6hY84L2FOf