Lorenz

Stem cell biologist @MSKCancerCenter studying human PSCs for modeling development & disease and for cell therapy. Opinions are my own and do not represent MSK.

[Memorial Sloan Kettering Cancer Center @MSKCancerCenter]

Dr. @TabarViviane and Dr. @studerl, physician-scientists at MSK, have developed a treatment for #Parkinson’s disease that involves creating nerve cells from embryonic stem cells and transplanting them into patients. Early results show the treatment is safe and may improve Parkinson’s symptoms.

"This is an important milestone on the road towards regenerative brain repair," says Dr. Tabar. "It represents more than two decades of collaborative work, based on very rigorous science beginning in our labs."

Learn more: https://t.co/QUOqYX0TRg https://t.co/VMG2nQtDR9

[Lorenz @studerl]

@FaranakFattahi @MayoClinicGIHep Congrats!

[Lydia Finley @lydfinley]

Things I wish more people knew about doing science in the US (thread):

[Lorenz @studerl]

Congrats to @ZeltnerLab on their new paper. Genipin rescues developmental and degenerative defects in familial dysautonomia models and accelerates axon regeneration | Science Translational Medicine https://t.co/vhjSE8Qthf. It was exciting to see this story develop from way back.

[Memorial Sloan Kettering Cancer Center @MSKCancerCenter]

👏 Congratulations to Dr. Deb Schrag, Chair of the @MSK_DeptOfMed, and Dr. @studerl, Director of the Center for Stem Cell Biology at MSK, who were elected to the @theNAMedicine, one of the highest honors bestowed upon scientists worldwide.

Learn more: https://t.co/N2NdRJv4TE

[Dr. Danwei Huangfu @DanweiHuangfu]

📢 Join us!
Developmental and stem cell biologists, checkout our tenure-track faculty position at Sloan Kettering.
Apply by October 18.
#DevBio #StemCell #hiringnow
https://t.co/9h9gl6EZEe

[Thomas Vierbuchen @TommyVierbuchen]

Excited to share the latest work from my lab and @em6wong led by @DanielMedinaC12 @tarek10281 @verpetrova.

We developed a new protocol to generate mouse cortical organoids from pluripotent stem cells.

@MSKCancerCenter @MSK_CSCB @MSKEducation

https://t.co/JSOnogfLuC

[Lorenz @studerl]

This was a great episode indeed. Congrats to @bigosi and @TabarViviane

[Stem Cell Podcast @stemcellpodcast]

🥇 The top spot goes to Drs. Stefan Irion (@bigosi) and Viviane Tabar (@TabarViviane)! This episode was recorded live at @BlueRockTx and focuses on bemdaneprocel — a stem cell-derived investigational cell therapy for Parkinson’s disease! #InternationalPodcastDay

https://t.co/uY16FcaT7B

[Stem Cell Podcast @stemcellpodcast]

Congratulations to Dr. Shuibing Chen (@ChenShuibing) on her lab's new @CellStemCell paper!

Her team developed vascularized macrophage-islet #organoids to study damage from infection.

Read the article: https://t.co/3n4X8STm5p

Learn more about her work 👇 https://t.co/8lUmovVE2a

[Lorenz @studerl]

Exciting opportunity for open tenure track positions in Developmental Biology & Stem Cell Biology @MSKCancerCenter (see Ad - https://t.co/BxutHyvFn1). Deadline for applications is October 14, 2024 (https://t.co/8SJujIBPP0)

[Lorenz @studerl]

Great postdoc opportunity if you are interested in developing next gen human PSC based cell therapies for brain repair here at MSK

[Viviane Tabar @TabarViviane]

We have a postdoc opportunity to work on cell therapy for #Parkinson’s disease in a highly collaborative environment @MSKCancerCenter @MSKEducation
Apply at https://t.co/iyoCYczNaM

[Lorenz @studerl]

Excited to see the work published @Nature. Excellent summary in thread below. Big collaborative effort with @ShenYingZhang1, @casanova_lab + many more. Special thanks to @yihaoo, @ZhiyongLiu7, Paul Bastard and in my lab @NoopurKhobrekar, Param Amin, @gabriele_ciceri & @harschnitz

[Shen-Ying Zhang @ShenYingZhang1]

1) Just out @Nature today! We show that human TMEFF1 is a restriction factor for #Herpes simplex virus 1(HSV1) in the brain, by limiting NECTIN1—HSV1-gD mediated HSV1 entry into cortical neurons. TMEFF1 defect can underlie HSV1 #encephalitis. https://t.co/ESeorkXBGC

[Lorenz @studerl]

Excellent thread from @ShenYingZhang1 on this new collaborative story, and for our lab one of the first studies to test run new hindbrain neuron protocol developed by @harschnitz

[Shen-Ying Zhang @ShenYingZhang1]

(1) We are happy to share our new study, “SARS-CoV-2 brainstem encephalitis in human inherited DBR1 deficiency” @JExpMed! https://t.co/WIRWBLH9RJ. Accumulation of RNA lariats results in impaired antiviral immunity in hPSC-derived hindbrain neurons, underlying encephalitis. https://t.co/UI6M7bwnxt

[Nathalie Saurat @NatSaurat]

Look, it’s the
@studerl
lab past and present at #ISSCR2024. Getting together is another awesome part of attending this conference 🤩

[Lorenz @studerl]

Super excited to see this study finally published after many years of work. Congrats to @NatSaurat for the heroic effort and to all the many amazing collaborators who made this work possible. Also big thanks to our funders particularly the JPB foundation, NIA and @ASAP_Research.

[Lorenz @studerl]

How to trigger age-related features in hPSC neurons? In a CRISPR screen @NatSaurat identified neddylation inhibition as a tool to trigger hallmarks of aging in neurons and selective degeneration in AD or PD but not isogenic control neurons. @cellstemcell https://t.co/vycsfPED6g

[Lorenz @studerl]

How to trigger age-related features in hPSC neurons? In a CRISPR screen @NatSaurat identified neddylation inhibition as a tool to trigger hallmarks of aging in neurons and selective degeneration in AD or PD but not isogenic control neurons. @cellstemcell https://t.co/vycsfPED6g

[Lorenz @studerl]

Excellent thread from @_SoyeonKoo on the paper (and also her thesis work 😊). Congrats!

[So Yeon Koo @_SoyeonKoo]

Excited to share that my doctoral thesis work is out in @CellCellPress

We investigated a molecular driver to trigger hPSC-derived midbrain dopamine neurons during engraftment in mice.

[Waggoner Lab @LabWaggoner]

@CellCellPress @TaeWanKim0 @studerl
Transient TNF-α inhibition overcomes a p53-dependent survival restriction in grafted dopamine neurons as a clinically relevant strategy to promote functional dopamine neuronal engraftment in Parkinson’s disease https://t.co/aREdwkYUeO

[Thomas Vierbuchen @TommyVierbuchen]

Excited to share our latest paper led by @rachelaglenn. We generated a genetically diverse mouse pluripotent stem cell panel from the Diversity Outbred stock and outline experimental approaches for "population-scale" in vitro directed differentiation.

https://t.co/hYkW2fJ1qo

[Lorenz @studerl]

Why do most dopamine neurons die shortly after transplantation and how can we fix it? Excited to see our story out at Cell. Congrats to @TaeWanKim0 & SoYeon Koo @MSKCancerCenter and to all the other collaborators who made this work possible. https://t.co/X2ZjkWGHQT