Yi Hua Chen-Neumann

PhD student
@MITCSBPhD
in the lab of Jonathan Weissman
@Jswlab

@WhiteheadInst
|| AB'20
@Harvard
|| she/her || Systems virology enthusiast 🦠

[Yi Hua Chen-Neumann @YiChenNeumann]

@Pictus_Lycaon @biorxiv @JswLab @labs_mann @Lougrauvogel @KatieEYost @EdwinNNeumann @WesleySuen @BenGewurz @elledge_stephen Hi! Yes happy to! Would you be able to reach out via email? Thanks!

[Yi Hua Chen-Neumann @YiChenNeumann]

Excited to share my PhD work, now on @bioRxiv! 🎓🦠Viruses are packed with small ORFs with unknown function. At @JswLab w/ collaborators, we built a pan-viral microprotein atlas that uncovered the oncogenic activity of BNLF2b, an EBV gene linked to cancer.
https://t.co/KYzeoMBvb5

[Yi Hua Chen-Neumann @YiChenNeumann]

@MartinBJensen @JswLab @labs_mann @BenGewurz @StephenE92884 @hopfnerlab Thank you!! Exactly, we hope to expand this dataset and develop it into a user-friendly platform for the community to explore and generate hypotheses!

[Yi Hua Chen-Neumann @YiChenNeumann]

@colininscience @biorxiv @JswLab @labs_mann @Lougrauvogel @KatieEYost @EdwinNNeumann @WesleySuen @BenGewurz @elledge_stephen Thank you!! Congrats on the viral ORFeome work too! Library construction alone must have been nontrivial & the range of screens/omics methods with mechanism was 🤯.

Excited to see what eORFeome/viral ORFeome studies will discover next!

[Yi Hua Chen-Neumann @YiChenNeumann]

@mike_tilapia @biorxiv @JswLab @labs_mann @Lougrauvogel @KatieEYost @EdwinNNeumann @WesleySuen @BenGewurz @elledge_stephen Also thought the 13.6K/i-leader protein story emerging from de novo splicing was really neat! Would be interesting to look out for this kind of evolutionary pattern for our unannotated hits from dsDNA viruses!

[Yi Hua Chen-Neumann @YiChenNeumann]

@mike_tilapia @biorxiv @JswLab @labs_mann @Lougrauvogel @KatieEYost @EdwinNNeumann @WesleySuen @BenGewurz @elledge_stephen Thank you & congrats as well on the eORFeome work! Great parallels with our findings too! Loved the p53 figure showing all the ways pathogens hijack that node. A beautiful illustration of convergence! 🤩

[Yi Hua Chen-Neumann @YiChenNeumann]

Capturing the birth of a new gene through sequence and phylogenetic analysis:

[Yi Hua Chen-Neumann @YiChenNeumann]

Identification of the oncogenic activity of EBV BNLF2b 🤯

[Yi Hua Chen-Neumann @YiChenNeumann]

Uncovering the birth of a new gene through sequence and phylogentic analysis:

[Yi Hua Chen-Neumann @YiChenNeumann]

We captured the birth of a new gene that independently emerged in multiple astrovirus lineages with different functions. This "gene nursery" expands functional capabilities from the same genomic real estate.

[Yi Hua Chen-Neumann @YiChenNeumann]

Deeply grateful to my mentors and colleagues @JswLab, co-author @Lougrauvogel from @labs_mann, along with our incredible collaborators from the Hopfner, Gewurz, and Elledge labs!