Edwin Neumann

PhD student @MITdeptofBE in the lab of Jonathan Weissman @Jswlab @WhiteheadInst || BS '19 @UWMadison || he/him || Epigenome editing enthusiast

[Edwin Neumann @EdwinNNeumann]

Sharing my first 1st author paper, now published in Science! For my PhD I engineered CHARM, a compact, enzyme-free epigenetic editor which can be delivered via AAV vector to reach the brain. This work was done in @JswLab with @TessaBertozzi and @ElaineWu0
https://t.co/DrV4EGe92z

[Doug Landry @douglandry]

But how is anyone supposed to know where to go? These maps are the sum total of what they put out and they’re total garbage

How is a regular person supposed to figure this out?

[Michael Baym @baym]

We live in an age of (NIH-funded) biomedical miracles

Within your lifetime, prion disease was considered potentially impossible to cure. Now there's a promising path towards one
https://t.co/HdW6nPrTVS

[Edwin Neumann @EdwinNNeumann]

@EAHellerPhD I'm sorry I must have missed out on this- could you link the study? Very curious!

[Edwin Neumann @EdwinNNeumann]

@ZinselmeyerB @BiotechAnalysst @JswLab @TessaBertozzi @ElaineWu0 I do miss being at @UWMadison and paying half the rent!

[Edwin Neumann @EdwinNNeumann]

Sharing my first 1st author paper, now published in Science! For my PhD I engineered CHARM, a compact, enzyme-free epigenetic editor which can be delivered via AAV vector to reach the brain. This work was done in @JswLab with @TessaBertozzi and @ElaineWu0
https://t.co/DrV4EGe92z

[Edwin Neumann @EdwinNNeumann]

Sharing my first 1st author paper, now published in Science! For my PhD I engineered CHARM, a compact, enzyme-free epigenetic editor which can be delivered via AAV vector to reach the brain. This work was done in @JswLab with @TessaBertozzi and @ElaineWu0
https://t.co/DrV4EGe92z

[Edwin Neumann @EdwinNNeumann]

@keaijumaomao @mn_whittaker @kiranmusunuru If it can be diagnosed early enough we can intervene. That's the goal.

[Edwin Neumann @EdwinNNeumann]

@Ella_Maru @JswLab @TessaBertozzi @ElaineWu0 Good question– that will be answered soon. DNA methylation without cell division should be stable without active recruitment of DNA demethylases, so I am optimistic that we will observe silencing with a fully optimized drug candidate for as long as we can measure it.

[Edwin Neumann @EdwinNNeumann]

@smead2 @JswLab @TessaBertozzi @ElaineWu0 Couldn't have done it without support from a spectacular PI and team :)

[Edwin Neumann @EdwinNNeumann]

@xinjin @JswLab @TessaBertozzi @ElaineWu0 Thanks Xin!

[Edwin Neumann @EdwinNNeumann]

We believe this will forge a path to a much-needed prion disease treatment, and we think CHARM could potentially be applied to other neurodegenerative diseases. Please also check out this excellent perspective piece by @mn_whittaker and @kiranmusunuru!
https://t.co/SpzJ8PdWQf

[Edwin Neumann @EdwinNNeumann]

Working with @FionaSerack & co. in the lab of prion experts Sonia Vallabh and Eric Minikel @cureffi, along with AAV expert Ben Deverman @DevermanLab & co., we demonstrate that CHARM can potently repress the prion protein throughout the mouse brain.

[Whitehead Institute @WhiteheadInst]

.@JswLab and @broadinstitute collaborators have developed a gene-silencing tool that shows promise as a therapy against fatal prion diseases. The tool, called CHARM, paves the way for a new class of genetic approaches to treat certain diseases: https://t.co/5RjeUkx3J1

[Eric Vallabh Minikel @cureffi]

Introducing CHARM: a new epigenome editor to methylate DNA at the promoter of a targeted gene.
Our lab's collaboration with @JswLab's @EdwinNNeumann & @TessaBertozzi shows deep silencing of brain PrP

Paper: https://t.co/HZRKk2m1b2

Blog: https://t.co/crVVYpyI6w

[Gayathri Muthukumar @GayathriArunaM]

Excited to share my first paper from grad school out today in @MolecularCell! We systematically define biogenesis pathways for alpha-helical OMM proteins triaged by the NAC and TTC1 chaperone complexes for polytopic and signal-anchored proteins (1/2).
https://t.co/UGB8yhKnBW

[Eric Vallabh Minikel @cureffi]

On @medrxivpreprint today, we describe the plasma & CSF biomarker changes leading up to symptom onset in 4 cohort study participants who went on to develop active prion disease https://t.co/behU25E1IN

[Edwin Neumann @EdwinNNeumann]

@thestrecker @durocher1 @zhangf @MGHMolBio Congratulations Strecker! Unfortunately I am unable to admire your new website thanks to the @WhiteheadInst firewall 🤔

[David R. Liu @davidrliu]

Three of the more costly and frequently used reagents in molecular biology are rolling circle amplification (RCA) mix, chemically competent MachOne (or other E. coli) cells, and Gibson assembly mix. Postdoc Julian Willis—who is starting his own lab in the UK soon—developed homemade recipes for each that reduce costs ~3x (or more at large-scale). Links to each recipe:

RCA mix:
https://t.co/Cmir57uM0J

Chemically competent MachOne cells:
https://t.co/kNYVxLIToA

Gibson assembly mix:
https://t.co/OFwXmmLDWB

[Jonathan Weissman's Lab @JswLab]

We are looking for a motivated recent grad (or soon-to-be grad) to join us as a lab technician! A great opportunity to gain research experience for 2-3 years before applying to MD and/or PhD programs. Apply here: https://t.co/ykjTq5yIxT

[Julia Joung @JuliaJoung]

Thrilled to share my primary PhD work: a Transcription Factor Atlas for understanding gene regulation and cell engineering @CellCellPress. We created a comprehensive TF ORF library and applied it to profile resulting expression changes. A thread 1/X https://t.co/PPcJ0HZEsW