Yingshan Bi

[DrawImpacts @DrawImpacts]

🎉 Happy New Year from #DrawImpacts Studio! 🎨

We’re thrilled to kick off 2025 with exciting news: our first cover of the year has been selected for @CellStemCell's inaugural issue of 2025!! Here’s to another year of impactful collaborations, science, and creativity—we can’t wait to see what this year brings! 🌟

"Regulated GATA1 expression as a universal gene therapy for Diamond-Blackfan anemia." 💎
👉Learn more about this groundbreaking research: 🔗 https://t.co/VCspywujz2

💎🪭 In this issue, @RichardVoit et al. report on the development of a unified gene therapy approach applicable to all patients with the inherited bone marrow failure syndrome Diamond-Blackfan anemia (DBA). Mutations in one of more than 30 genes cause erythroid maturation arrest in DBA, but regulated lentiviral expression of the transcription factor GATA1 exclusively in developing erythroid progenitors overcomes the erythroid maturation arrest irrespective of causative gene mutation and improves erythroid output in DBA.

🎨The cover image depicts a blood factory, representative of the bone marrow, with hematopoietic stem cells undergoing differentiation. Some developing cells commit to erythroid differentiation but are blocked by a pile of rubble with diamonds and black fans, representing DBA. To overcome this, factory workers labeled GATA1 are running to help carry the progenitors around the obstacle, leading to increased production of mature red blood cells.

Congratulations to all the authors!
#DrawImpacts #coverart #science #sciart #scientificillustration #cellstemcell #scientificjournal #scicomm #sciencecommunication

[Sally G Pasion @sgpombe]

Genuine JOY! Traveling >2400 miles (and nearly five years) to the #TAGC24 meeting and bumping into Sam (Yingshan Bi)-one of our 2019 Summer @NIH #Bridges to the Baccalaureate students @SEO_SFSU @SFSU @UCBerkeley who is now a #PhD student at @JHUArtsSciences. My ❤️ is singing!