Yongsub Kim

Associate professor @ University of Ulsan College of Medicine (UUCM), Asan Medical Center (AMC).

[Yongsub Kim @Yongsub__Kim]

@ScholarshipfPhd YES!

[Yongsub Kim @Yongsub__Kim]

Happy to share our lab's preprint! 📄 We've developed base editors with SsdAtox, a novel DYW-like deaminase from Pseudomonas syringae, effective for both ssDNA and dsDNA! #GenomeEditing #CRISPR #BaseEditing https://t.co/2XEIt79Y8F @biorxivpreprint

[Yongsub Kim @Yongsub__Kim]

We've previously reported PAM variable PEmax for correcting KRAS mutations, and now our constructs - PEmax-SpG, PEmax-SpG-P2A-hMLH1dn - are available on @Addgene! Check them out! #CRISPR #PrimeEditing
https://t.co/YAp6jAElQE

[Wei Zhao @zhaoweiasu]

1. The title of the recently published paper, "Genotoxic Effects of Base and Prime Editing in Human Hematopoietic Stem Cells," is quite catchy and unsettling. However, the few points it covers have largely been extensively studied before.
https://t.co/D28TcDVrpI

[Nicole M. Gaudelli @NicoleGaudelli]

First patient dosed with Beam-201! 💫 https://t.co/6xkkjuH3U5

[David R. Liu @davidrliu]

Today we report in @CellCellPress a suite of engineered and PACE-evolved prime editor variants PE6a-g. These new prime editors improve the activity, in vivo deliverability, and in vivo editing efficiency of prime editing.
https://t.co/xdF6j0zn8Y
PDF:https://t.co/iRegR74CKg
(1/15)

[Nature Biotechnology @NatureBiotech]

Strand-preferred base editing of organellar and nuclear genomes using CyDENT https://t.co/Mx0U5REwxy

[Niko McCarty. @NikoMcCarty]

A typical human cell expresses ~150-400 transcription factors. These proteins bind to DNA to regulate gene expression.

And >half of them also bind RNA.

Prior studies have shown that a "few TFs" bind RNA, but this one finds many more. (h/t @alectricity)

https://t.co/3FKKnsxo8E

[Communications Biology @CommsBio]

A #CRISPR prime editing approach from @Yongsub__Kim corrects all types of G12 and G13 oncogenic KRAS mutations using a universal pegRNA, demonstrating the potential of applying this system to KRAS gene therapy through a one-to-many approach.

https://t.co/ItSCXp7Hu0

[Feng Zhang @zhangf]

Since the discovery of CRISPR-Cas systems, people have wondered if a similar type of system exists in eukaryotes. Today, we report in @Nature the characterization of Fanzor, a eukaryotic RNA-guided system that can be reprogrammed for human genome editing. https://t.co/aKLMMEBRkk

[David R. Liu @davidrliu]

A new report in @NEJM from Waseem Qasim and coworkers describes the clinical outcomes of the first three T-cell leukemia patients treated with triply base-edited CAR-T cells in the first clinical trial of a base edited therapeutic, conducted at Great Ormond Street Hospital in the UK.

(Peter Pan’s legacy lives on, as GOSH is funded in part by James Matthew Barrie’s gift to GOSH of rights to all royalties from Peter Pan!)

[bioRxiv @biorxivpreprint]

Discovery of new deaminase functions by structure-based protein clustering https://t.co/GK5wl6k0z3 #bioRxiv

[SNIPR @sniprbiome]

🚨We have published a paper in @NatureBiotech!

Find out more about the development of a #CRISPR-therapeutic to eradicate E. coli in hematological #cancer patients, potentially preventing fatal infections.

Read the publication (open access) here: https://t.co/pv2U4l9izm

[David R. Liu @davidrliu]

Today we report in @NatureBiotech the development of dual-AAV in vivo delivery systems for prime editors that can support efficient prime editing in multiple organs such as brain, liver, and heart.
1/4

[Nature Biotechnology @NatureBiotech]

A highly efficient transgene knock-in technology in clinically relevant cell types https://t.co/ClbIvpMNUT

[Yongsub Kim @Yongsub__Kim]

It's the lab's first logo!

[Yongsub Kim @Yongsub__Kim]

We report "Therapeutic gene correction for Lesch-Nyhan syndrome using CRISPR-mediated base and prime editing" in Molecular Therapy- Nucleic Acids. Congrat Gayoung & Ha Rim!

https://t.co/PYTHbLIBGd

[Edilytics @edilytics]

Congrats to See and @Yongsub__Kim on publishing their protocol on analyzing BRCA1 variants using Base Editors.

Thanks for using #crispresso2! https://t.co/5aVDxy93d7

[Yongsub Kim @Yongsub__Kim]

Today we report small size of CRISPR base editors using Campylobacter jejuni Cas9.
https://t.co/fXcJCTVTjV

[bioRxiv @biorxivpreprint]

CRISPR prime editing for unconstrained correction of oncogenic KRAS variants https://t.co/8a64cGNv7d #bioRxiv