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[Miles Cranmer @MilesCranmer]

This is an insane paper and I love it

https://t.co/DP8OR5NJf2

[Sebastian Caliri @SebastianCaliri]

Evidence-based medicine is a blessing of the 20th century. Evidence-based medicine is also a curse of the 20th century.

Medical interventions are studied through randomized controlled trials and those interventions are assessed for efficacy and safety on a population level. But no individual quite matches some blended average of every trial participant. Rather, everyone's biology is unique.

Sid Sijbrandij just presented the story of his cancer journey at OpenAI forum. When Sid ran out of evidence-based treatment options, he didn’t accept the boundary but rather began treating his cancer like an engineer:
- multi-omic tumor profiling at extreme depth
- N=1 drug development (vaccines, TCR-T, radioligand therapy)
- parallel treatment strategies
- continuous measurement (ctDNA, single-cell, immune state) and refinement

Rather than protocol-based care, Sid built a learning loop. Maybe the future of medicine in a world where gathering and interpreting data gets cheaper and cheaper looks more like a loop.

Thanks for sharing @sytses and @jacobjstern !

[Tim Miller @Timodc]

Still trying to wrap my head around Kash firing a unit that specializes in Iranian counter-intel LAST WEEK -- when they knew war was coming -- because the agents were involved in the Trump classified docs case.

https://t.co/1586YuzT5e

[Jonathan Weisman @jonathanweisman]

In 2019, the State of New Mexico launched an investigation of Jeffrey Epstein’s Zorro Ranch, then the Trump 1 Justice Department demanded the state stop and turn it over to the feds. The probe then fizzled. Awesome reporting from @ReisThebault https://t.co/CGQeZh3olo via @NYTimes

[Covie @covie_93]

Good thing Congress isn't alive to see this.

[Thomas Massie @RepThomasMassie]

Some of us never forgot.

[Aaron Rupar @atrupar]

Crockett: "I don't really know where we are in this country. Why are we even having this conversation? The United States is falling apart right now, partially because he's allowing for the killings of people in the middle of the street, but the other part of it is we have a 34 count convicted felon and there are people that are still shielding him from any type of accountability as it relates to a child sex trafficking ring. I don't understand why we are pretending like any of this is normal."

[Andrew Leyden @PenguinSix]

Former Washington Post reporters launch GoFundMe to help repatriate international staff who was fired and now facing logistical challenges getting out of their countries and back home. https://t.co/sXGJaUKnR2

[Lizzie Johnson @lizziejohnsonnn]

I was just laid off by The Washington Post in the middle of a warzone. I have no words. I'm devastated.

[Michael Linden @MichaelSLinden]

I have a much better idea: maybe rich people could pay the back a fraction of the trillions in tax cuts they've been given over the past 20 years.

[Tommy Vietor @TVietor08]

Your legacy, @elonmusk

[Hayden @the_transit_guy]

Me finally being able to ride high speed rail in the United States at the age of 92:

[Mohamad Safa @mhdksafa]

Seems like the Epstein files are full of billionaires and not immigrants.

[connor @ConnorEatsPants]

anyone else starting to question President Trump’s leadership

[connor @ConnorEatsPants]

bitch @JDVance

[Matt McDermott @mattmfm]

ICE is now responsible for 66% of the homicides in Minneapolis this year.

[Paul Graham @paulg]

Jessica's friend's cousin, a random white guy in Minnesota, had his apartment invaded by ICE with drawn guns. They claimed they had a warrant, but they didn't. They were going door to door in his building.

[Jamie Bonkiewicz @JamieBonkiewicz]

Anyone else notice how the “fishing boats full of drugs” storyline disappeared the second Trump got the oil?

[Kaivan Shroff @KaivanShroff]

The real Trump Derangement Syndrome…

2016 2026

[derek guy @dieworkwear]

crazy to me that last year we said we don't have enough money to cure cancer but now we're trying to buy greenland