The Yttri Lab

Interrogating the functional interactions of motor and decision circuits that lead to behavior. (he/lab - not official)

[The Yttri Lab @YttriLab]

A fun article about our work and the Olympics.
There's some interesting relationships between skiing and basal ganglia function
@CmuScience @ahmari_lab @BarbShinn

https://t.co/Z5QORCcfsu

[The Yttri Lab @YttriLab]

and super cool neurocampus building!

[The Yttri Lab @YttriLab]

super excited to be giving a talk today at University of Bordeaux. thank you Nicolas Mallet for the invitation!!!

[The Yttri Lab @YttriLab]

I am so curious and fascinated to find out what the heck this is

[The Yttri Lab @YttriLab]

Here's the tweetprint on pain, blocking its affective content, and its effect on behavioral and neural dynamics!

[⚡️GREG_CORDER⚡️ @FlyBottleEscape]

🧠⚡️💊New @Nature publication !

Mimicking opioid analgesia in cortical pain circuits

We built a brain-behavior framework to decode spontaneous chronic pain in mice—and to biologically mimic morphine with a synthetic opioid gene therapy

https://t.co/YqvBzdEqEL

@PennMedicine

[The Yttri Lab @YttriLab]

ok. 2 cool science summaries:
1)we discovered clear, discrete pain states - not just behaviors
2)no-pain and treated-pain were not the same, in part due to intervention targeting just the affective side, not numbing everything. Also kinda makes sense in my personal experience?

[The Yttri Lab @YttriLab]

Hot off the @Nature press! A-SOiD behavior library developed specifically for pain studies quantifies a new chemogenetic gene therapy that targets opioid circuit in ACC without addictive properties
@FlyBottleEscape @CmuScience @cmuneurosci
https://t.co/81jphkV5dk

[The Yttri Lab @YttriLab]

I'll let Greg do the tweetprint, but he led a Phenomenal interdisciplinary team effort. Great science in every way.

It's open too! Also part of the paper, you can build your own behavior rig with full analysis software for a tenth the price of commercial. Inquire if interested

[The Yttri Lab @YttriLab]

So proud of @MattGeramita and his stellar work on striatal dynamics, decisions, and impulsivity. Pertinent for thinking about prob vs deterministic frameworks too.
Also, suggests indirect may be doing more(cognitive?) than just opposing direct pathway
https://t.co/lMAATsLLO2

[The Yttri Lab @YttriLab]

Come see Paul present his very cool data + analysis today at 1pm @SfNtweets

[Paul Middlebrooks @pgmid]

If you're at SfN, stop by my teeny tiny nano talk Sunday at 1:
"Neural population dynamics during naturalistic versus task-related behavior" w/
@YttriLab
@Markolas11
@adenoeagle
NANO017.01

[The Yttri Lab @YttriLab]

SPNs are briefly active + only for specific events. When driven randomly or for long dur, interpretation is hard. SPN attenuate response to light after a few secs (and Bstem response?)
These results indicate STR's role in policy-based RL + are at odds with basic action selection

[The Yttri Lab @YttriLab]

Huh, it's been 8 months since I was on here. Better late than never. I hope this new-ish paper will challenge people to think about the interpretations of our models
STRIATUM SUPPORTS REINFORCEMENT AND NOT ACTION SELECTION (!!!)
https://t.co/l6GrB2c7Pb
@CmuScience @cmuneurosci

[The Yttri Lab @YttriLab]

When applied contra, ipsi, or bilaterally to left turns, the effect was the same: D1/D2 stim biased mice to turn left more often, regardless of the side of stim. Note, bias is incomplete and did not induce an action, consistent with learning but not action selection

[The Yttri Lab @YttriLab]

excited to be giving a talk @ UPenn today, with invite from @Fuccillomarc and @FlyBottleEscape
A preview of my first slide....

[The Yttri Lab @YttriLab]

I'm still chewing through this one, but I think it's a keeper
https://t.co/hLizIJFJEf

[The Yttri Lab @YttriLab]

I'm revamping a masters-level Systems Neuro course this spring.
Please HMU with your favorite reviews and perspective pieces! Extra points for approachable and/or thought-provoking.
Any topic is welcome! I might end up biasing to the BME-heavy audience

[The Yttri Lab @YttriLab]

Super exciting work and possibilities discussed today in the Brain Behavior Quantification and Sync consortium kickoff today!!!
Great job to all

(and got nerves for a talk for the first time in a while!)