Yulong Li Lab

Yulong Li, Prof. of Peking Univ. : PKU (BS, Beijing) - Duke Univ. (PhD, Durham) - Stanford Univ. (Postdoc, Palo Alto) - PKU (Prof. , Beijing)

[SeYeon Chung @seyeon_chung]

Excited to see another fantastic lineup of invited speakers for #Dros27! 🪰 Looking forward to hearing from @yulonglilab, Kim McCall & José (Pepe) Pastor-Pareja, and to another great gathering of the Drosophila community in Philadelphia! 🧬

[Yulong Li Lab @yulonglilab]

intriguing work demostrating the function of endocannabinoids in vivo.

[Lab of Dr. Nephi Stella, University of Washington @StellaLab11]

Excited to share our study published today in Nature! This work by the CB Network at the University of Washington was led by Dr. David Marcus, myself and Dr. Micheal Bruchas. Considering how challenging it is to publish in such a high impact journal, I am full-on celebrating.

[Yulong Li Lab @yulonglilab]

(6/6) Together, these sensors turn a bulk eCB readout into ligand-specific signaling, from neural activity to behavior. Great work by the team, and huge thanks to all our collaborators! @_RuyiCai @aodongpku @Huan_HWang @ZhaofaW @StephCragg

#GRABSensors #neuroscience #eCB

[Yulong Li Lab @yulonglilab]

A long-standing question in neuroscience is why the eCB system uses two ligands for the same receptors and how their release differs. To address it, we’re happy to share a pair of selective GRAB sensors that detect 2-AG and AEA, respectively, in real time.
https://t.co/wF1H9kmTrB

[Yulong Li Lab @yulonglilab]

(5/6) One particularly interesting finding: Δ9-THC triggered a large, sustained, dose-dependent 2-AG signal, but no detectable AEA, in the NAc shell. This reveals a previously unappreciated interaction: an exogenous cannabinoid can recruit endogenous 2-AG signaling in vivo.

[Yulong Li Lab @yulonglilab]

@rclopez1618 Nice work for the community!

[Yulong Li Lab @yulonglilab]

@zenbrainest One can never do more controls... caution needs to be exercised to interpret sensors' signals. One additional common problem is that co-relation is really not equal to causality...

[BryanRoth @zenbrainest]

Using imaging in mouse brains, we find that norepinephrine and dopamine cross-activate the respective sensors.
https://t.co/JrzJowFN0P

[Yulong Li Lab @yulonglilab]

Join us at #FENS2026 for Chinese-European Frontiers in Neuroscience, a CNS Satellite Event!
Co-chaired by Profs. Yulong Li & Rosario Moratalla, with leading researchers exploring pain research & neuromodulation while fostering CN-EU collaboration.
📍 Barcelona | 📅 July 5

[Yulong Li Lab @yulonglilab]

Using fiber photometry, mesoscopic imaging, and two-photon microscopy, we simultaneously monitored ACh together with DA, 5-HT, NE, and calcium signals with high spatiotemporal resolution.
@NatureNeuro @ShuXieEddie @yu98449099 @_RuyiCai @JiesiF
https://t.co/gU3cBDN4zP (3/3)

[Yulong Li Lab @yulonglilab]

Excited to share our first red ACh sensor!
We developed GRAB_rACh1h, the first genetically encoded red fluorescent sensor for recording acetylcholine dynamics in vivo. （1/3）

[Yulong Li Lab @yulonglilab]

Compared with existing ACh sensors, rACh1h exhibits larger responses (5-fold ΔF/F0 relative to gACh3.0), larger SNR and higher affinity. Most importantly, its red-shifted spectrum enables multiplex recording with green fluorescent sensors. (2/3)

[Yulong Li Lab @yulonglilab]

From Duan's lab, it must be good

[Xin Duan @xinduan]

A collaborative paper with Ge/Wei/Scanziani @UCSFPhysiology @hhmi_science: integrating our anterograde trans-neuronal tracer (mWGA-mCherry, PMID: 35524141) with MERFISH to decode visual circuits in brain #Braininitiative #Brainconnects @NatEyeInstitute https://t.co/wNjoU6UgId

[Society for Neuroscience (SfN) @SfNtweets]

Presenting at #SfN26 provides more eyes on your work, more feedback from your peers, & more opportunity to build the collaborations that move your research forward.

Abstract submission is open through Wednesday, June 10.

Don’t miss out. Submit today.

🔗 https://t.co/shlcIGrFXp

[Yulong Li Lab @yulonglilab]

Very cool study from Dayu Lin's group!

[Dayu Lin @moccalin]

What has changed in mama bear brain (well, actually mice) to make her risk her life to attack a potential threat and protect her young? Oxytocin is the key! Happy to share our new study led by two awesome postdocs: Takashi Yamaguchi and Rongzhen Yan.
https://t.co/wInz2rVo8M

[Yulong Li Lab @yulonglilab]

important study!

[nature @Nature]

Nature research paper: Deconstruction of a spino-brain–spinal cord circuit that drives chronic pain

https://t.co/Dp1eqeBgns

[Yulong Li Lab @yulonglilab]

@NeuroCellPress We hope our new GRAB probe could help the whole field to yield new insights regarding these important lipid signals in vivo, e.g. in the brain- body interaction.