Down syndrome lowers the risk of most solid tumors, and the molecular biology is fascinating.
People with Down syndrome have 3 copies of chromosome 21, which carries a gene, Dyrk1a, that promotes degradation of a key cell cycle protein, cyclin D1 - the extra copy of Dyrk1a in Down syndrome lowers cyclin D1 levels, so the cell cycle slows down.
This is one reason the risk of solid tumors is cut in half (the same is not true, unfortunately, of blood cancers, where the risk in Down syndrome is much higher).
An #OpenAccess review on current status of KRAS inhibitors, resistance drivers & potential combinations from @derlabunc@cjder23@papkephd & colleagues @DKFZ@ChariteBerlin in @trendscancer
As always very informative illustrations:
A: Frequency of KRAS Allelic alterations across various cancers
B: Current portfolio of KRAS inhibitors separated by allele specific & agnostic compounds
C: Common mechanisms of genomic & non genomic resistance
D: Potential combinations that are being trialed in preclinical setting & in the clinic.
President Carter’s melanoma journey highlights the power of research. Immunotherapy turned his stage IV diagnosis into hope. Since 2011, 14 @US_FDA -approved therapies have transformed outcomes, offering remission or even cures. Investing in science truly saves lives!
@JeromedeFt @Ordoscopie Toi tu seras remboursé de la même manière. En revanche, pour eux il n'est pas possible de côter les 2 actes sur la même consultation... Donc c'est un manque à gagner, d'où la convocation séparée (parfaitement absurde... Merci système de tarification idiot)
@BestForexMethod Used the Waka Waka one. Pretty good if you manage risk. Just a simple stupid martingale.
Never paid for it though...
Backtests are completely overselling it as always.
New traders
Online trading is probably the very worst industry known to man for scammers
Trading is the hardest thing I ever tried to do
99.9% of sellers will be failed traders
Book sellers
Course sellers
Live room sellers
Signals sellers
Trading bot sellers
Bot coders
etc
Hey 👋🏼 #3crSquad#3cr ... I have decided to make all my indicators FREE and I'll explain why below. So take a look https://t.co/2vriLgIK2u and download more sophisticated indicators that were paid but now are free. /1
@BestForexMethod The other one simply accused me of copy trading without ever showing proof... I tried defending myself, sending setfiles etc, then understood it was a waste of time and I'd never get paid.
@BestForexMethod One was something random with ''non complying with the rules'' and they just cancelled most of my trades to reduce profit (got like 200$ instead of 4k)..
@WonsElom@BestForexMethod And yes, zero spread definitely changes things, I don't know what's best between zero spread but commissions or shitty spreads no commission...
@WonsElom@BestForexMethod My spread is around 13 (backtested with 20 and 15).
And yes I put the correct trading hours !
I will run some optimisation on it because looking at the trades live, they seem "right" most of the time, but sometimes fail because they reach SL before TP or things like that.
@WonsElom@BestForexMethod my equity curve backtesting (your setfile) on EU from 11/04 to today 😂
wondering if it's related to spread or poor data quality
(I am also forward testing it with very small lots on a live account to see how it truly performs)