Ceniz Zihni

We study cellular structure, mechanics, and molecular signalling to develop therapies for vision loss.
#Aging #iPSC #Organoids #Membrane #Cytoskeleton #Nucleus

[Ceniz Zihni @ZihniLab]

Our most recent study demonstrates the assembly of a molecular clutch mechanism at apically positioned integrins of the retinal pigment epithelium. An unusual epithelium in that it faces an extracellular matrix at its apical side called the interphotoreceptor matrix.

[Journal of Cell Biology @JCellBiol]

Cdc42-activated MRCKβ signaling regulates actomyosin dynamics to drive phagocytosis. Stimulation of apical actomyosin activity is sufficient to rescue phagocytosis in deficient patient iPSC-derived RPE cells. By @ceniz_zihni et al @BaldaMatterLabs @UCLeye: https://t.co/mmgyvnYRRH

[Ceniz Zihni @ZihniLab]

@menunver @ekremacikel Ben katilirim sana- ama bu tipler kinli

[Ceniz Zihni @ZihniLab]

A great study from Fernando's lab.

[Fernando Martin-Belmonte @Fernand49142950]

Excited to share our new study in @NatureComms!
We uncover a key role for noncanonical autophagy (CASM) in neural tube formation through mb remodeling and endocytic recycling.
Using human neural tube organoids, we reveal mechanisms that may be relevant to neural defects. 🧠🧬

[Ceniz Zihni @ZihniLab]

@eczozgurozel Sayin Ozel, Neden hâlâ İmmamoğlu'nun talimatlarını izliyorsunuz?

CHP ve Türkiye için istikrarsızlığı en aza indirgemek üzere bir kurultay müzakere etme şansınız var. Sadece İmmamoğlu'nun hayallerini kurtarmak için bunu yapma şansınızı yok ediyorsunuz.

[Ceniz Zihni @ZihniLab]

@fevrisosyologg Whats interesting is Kilicdaroglu is getting over 10M views on his latest comment compare to far less by Immamoglu and Ozel. Is it possible there is a huge CHP crowd that prioritizes integrity and decency over electoral success? Just a thought...

[Ceniz Zihni @ZihniLab]

@fevrisosyologg First when talking about something get you facts correct or no intelligent person will take you seriously. Bilgi university not Bilkent.

[Ceniz Zihni @ZihniLab]

@ZelenskyyUa Stay strong- you are reaching a level of military innovation, customized for your specific situation, that will eventually reverse this aggression. Just stay strong with the correct believe that you are on the side of good and all good people around the world are with you.

[Ceniz Zihni @ZihniLab]

@kilicdarogluk Be strong genel baskanim and good luck with cleaning out our precious CHP from thieves and cheats.

[Ceniz Zihni @ZihniLab]

Lovely work.

[Peter Ly @PeterLyLab]

Excited to share our latest paper, out today @CellCellPress. We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. (1/7)

https://t.co/SbshGhofN0

[Ceniz Zihni @ZihniLab]

Useful tool.

[Chromatin labeling and imaging @AndImaging]

New preprint !

OptiFoot allows imaging of protein–nucleic acid interactions and places them into sequence context using Optical Genome Mapping, bridging super-resolution microscopy with single-molecule genomic analysis.

#Genomics #Chromatin #Microscopy

https://t.co/LOtKH8dnkK

[Ceniz Zihni @ZihniLab]

@DailyTurkst You can speak of Fantasytsan - all in your head.

[Ceniz Zihni @ZihniLab]

Great work with huge implications towards our further understanding of nuclear-force-coupling.

[Extracellular Matrix News @ExtracellMatrix]

Researchers at @_BIST demonstrated that the formation of fibrillar adhesions locks the nucleus in a mechanically deformed conformation, setting the mechano-response timescale to that of fibrillar adhesion remodeling.

@NatureMaterials | https://t.co/b9gL0cvQnI

[Ceniz Zihni @ZihniLab]

A great study- exciting and promising area for a potentially selective and potent destruction of cancer cells.

[Ahmet Cingöz @ahmetcingoz]

🎉 Excited to share my friend & colleague @NihalOlcay's new paper on genetically engineered human cell-based microrobots for selective cancer cell killing—now out in @ScienceAdvances! 🤖🧬
Unlike conventional microrobots that rely only on physical targeting, these living systems combine magnetic guidance with biological specificity—secreting tumor-targeting proteins to eliminate cancer cells while sparing healthy tissue.
A step toward smarter, more precise cancer therapies. 🎯
https://t.co/iVAhAUU5yC

[Ceniz Zihni @ZihniLab]

Interesting...

[Deepa Rajan, PhD @DeepaHRajan]

How can a single cell learn without a brain? We explore this in my new paper with @WallaceUcsf! We discovered that single cells may learn using molecules similar to those that animal brains use to learn, like CaMKII. Cells can also propagate memory states to their progeny! 🧵1/n

[agadmator @agadmator]

History has been made today. At just 14 years old, Yağız Kaan Erdoğmuş crosses 2700 threshold on live ratings, becoming the youngest player in the history of chess to do so. A monumental achievement for Yağız and a proud day for Türkiye. 🇹🇷

[Ceniz Zihni @ZihniLab]

@EndgameaiChess Sad to see less successful players acting jealous whilst the elite are wishing Yagiz more success.

[Ceniz Zihni @ZihniLab]

@c5piyonu Nonsense- the simultaneous European tournament he mentions was won by an IM and not a GM. He would have gained even more points there. Whilst elite players are happy for Yagiz its sad to see less successful players making a fool of themselves.

[Ceniz Zihni @ZihniLab]

@lachesisq I respect your game but don't agree with your comments regarding Erdogmus' 2700 rating. It is a pleasure for all chess fans to watch someone who is a generational talent. I will be viewing with great interest when you eventually play each other.

[Ceniz Zihni @ZihniLab]

Lovely work.

[Gregory Copenhaver @copenhaverlab]

Our (@mei_newt, Corbin Jones & me) #Meiosis, Recombination & Evolution of Sex class @UNC_Biology loved talking w/ @GertonJennifer from @ScienceStowers about her super cool @Nature paper on human #Robertsonian chromosomes + a sneak peak at unpublished work!
https://t.co/DiU8AxLtr8

[Ceniz Zihni @ZihniLab]

This fantastic work introduces a groundbreaking framework, in living tissues, for programming 3D shape transformations.

[Xavier Trepat @XavierTrepat]

Our latest work on shape-programmable tissues is out in @ScienceMagazine.
https://t.co/6Nbo3srcvE
Collab with Marino Arroyo’s lab, led by @pauguillamat at @IBECBarcelona

[Ceniz Zihni @ZihniLab]

A super achievement - congratulations!

[Javokhir Sindarov @GMJSindarov]

I won candidates !