Zlatic Lab

Deciphering circuit mechanisms of learning and action-selection at @MRC_LMB

[Zlatic Lab @ZlaticLab]

👋 It is out! Our joint effort to create a complete synaptic connectome of Drosophila larval brain came true and is published in @ScienceMagazine: https://t.co/OCjqSSsReJ
Amazing work by @WindingMichael, @bpedigod + colleagues from @MRC_LMB @Cambridge_Uni @HopkinsEngineer @JHUBME

[nature @Nature]

Scientists have generated the first complete map of the brain of a small insect. The map shows all 3,016 neurons and 548,000 synapses tightly packed in a young fruit fly's brain, which is smaller than a poppy seed https://t.co/jhy3CGmSZg

[Michael Winding @WindingMichael]

We’ve generated a synapse-resolution map of an insect brain, includes 3016 neurons and half a million synaptic sites! Out today in Science https://t.co/l3W5PEbhtJ

Summary below and in @bpedigod’s thread. @ZlaticLab, @albertcardona, @neuro_data, Carey Priebe, and many others

[Cambridge University @Cambridge_Uni]

How does the brain work? 🧠

Today, scientists reveal the first complete brain wiring map in a relatively complex animal.

The map can help understand how signals travel through the brain to drive behaviour and learning 👇

@PDN_Cambridge @CamZoology @MRC_LMB

[Ben Pedigo @bpedigod]

Our work studying the connectome of an insect brain, that of a Drosophila larva, is out today in Science! https://t.co/GWx4HSSIVr Some highlights below and in @WindingMichael’s thread. Work with @neuro_data, Carey Priebe, @albertcardona, @ZlaticLab, and many others.

[Zlatic Lab @ZlaticLab]

@WindingMichael @BPedigo @albertcardona @neuro_data @bpedigod thread ;)

[Johns Hopkins Engineering @HopkinsEngineer]

More coverage of @neuro_data and @ZlaticLab's groundbreaking work, out today in @ScienceMagazine.

[Zlatic Lab @ZlaticLab]

@behaviOrganisms @ScienceMagazine @WindingMichael @bpedigod @MRC_LMB @Cambridge_Uni @HopkinsEngineer @JHUBME Thank you 😊

[Zlatic Lab @ZlaticLab]

👋 It is out! Our joint effort to create a complete synaptic connectome of Drosophila larval brain came true and is published in @ScienceMagazine: https://t.co/OCjqSSsReJ
Amazing work by @WindingMichael, @bpedigod + colleagues from @MRC_LMB @Cambridge_Uni @HopkinsEngineer @JHUBME

[Tim Mosca (he/him) @drosophilosophy]

ok. i've peaked. it's all downhill from here. i was interviewed as the "expert not involved in the study" by GIZMODO (!!😍!!) on the new larval connectome paper, out today in science from @albertcardona, @ZlaticLab, and colleagues. amazing work!! https://t.co/vLpeMttpfx

[Zlatic Lab @ZlaticLab]

@matthewcobb @albertcardona Thank you 😊

[Zlatic Lab @ZlaticLab]

The complete synaptic-resolution connectome comprises 3016 neurons and 548,000 synapses. We believe that this complete brain connectome will be a lasting reference study, providing a basis for a multitude of theoretical and experimental studies of brain function in general🧠

[Zlatic Lab @ZlaticLab]

We would like to cordially thank to @albertcardona, Carey Priebe, @jovo, Volker Hartenstein, Richard Fetter and their labs and @HHMIJanelia for all the support on this journey 🙏

[Zlatic Lab @ZlaticLab]

Good luck @WindingMichael 🥳 We'll miss you...

[Michael Winding @WindingMichael]

I am starting my own research group at @TheCrick Institute in London! We will be investigating how neuronal circuits in the brain drive social interactions between animals.

I have an immediate opening for a PhD student, apply by 22 March!
https://t.co/WlwIUUgdbU

[Zlatic Lab @ZlaticLab]

3/3 In addition, our system will enable rapid screening for neurons and circuits that underpin different forms of learning and also has the potential to drive future research in larval taxis, decision-making, and spatial navigation and #memory.

[Zlatic Lab @ZlaticLab]

📢Did you know that we have developed a high throughput training system that allows real-time behaviour detection of freely moving larvae (up to 16) with targeted opto- and #thermogenetic stimulation of tracked animals in #Drosophila?

https://t.co/a8WpKlD2Gj
1/3🧵

[Zlatic Lab @ZlaticLab]

2/3 This stimulation is delivered automatically with high temporal precision and is controlled in either open- or closed-loop. Using this approach, we show for the first time that Drosophila larvae can perform classical #conditioning with no overlap between sensory stimuli.

[FlyWire @FlyWireNews]

Over 50,000 annotations have been added to the connectome by the FlyWire community!

This APL neuron, tagged by @mwpleijzier @zhihaozheng, is 20x longer than a fly's whole body and is the longest cell in the brain.

Proofread by labs of @gsxej @MurthyLab @sebastianseung

[Michael Winding @WindingMichael]

Sneak peek:
We will soon be releasing a complete insect brain connectome! With both brain hemispheres mapped, we can study how the left and right sides of the brain communicate #Drosophila #neuroscience

[Zlatic Lab @ZlaticLab]

👉 Our new preprint is out on #BioRxiv

It is a comprehensive work between our lab, @albertcardona lab and our collaborators, with our talented postdoc @WindingMichael as a co-first author and also one of the coresponding authors 🥳

[Michael Winding @WindingMichael]

Check out our new preprint: the complete #connectome of the entire #Drosophila larval brain, with all inputs and all outputs, and a comprehensive analysis of feedforward and feedback pathways across both brain hemispheres #Neuroscience https://t.co/DfzqHxhdVk