Guillermo Estivill Torrús

Neurobiólogo. Instituto de Investigación Biomédica de Málaga (IBIMA). Hospital Regional Universitario de Málaga. @HRegionalMalaga @_ibima @EpilepsiaMalaga

[Guillermo Estivill Torrús @_GEstivill]

Agradecemos al @SaludISCIII su empuje a este estudio que nos permitirá (@_ibima @HRegionalMalaga @hbellvitge @idibell_cat @TorrecardenasHU ) avanzar en el abordaje de neuropatologías con anticuerpos anti-GAD65, de tan difícil tratamiento . https://t.co/rOQ5DwEhHo

[Mayo Florida AutoImmune Neurology Group @Mayo_AING]

After both ECTRIMS2026 and American Neurological Association, I was reflecting on how #autoantibody-mediated neurological diseases are such precise clinical and biological entities. Few other diseases carry such homogeneity.

In 2023, @EoinFlanagan14 @adrianbudhram1 and I proposed it would be better to split, rather than lump. We suggested that the antibody itself - especially when highly specific - should be the gateway to diagnosis.

The fundamental demographics, clinical features and biological characteristics differ so markedly (see table) based on the antigen

It’s a key theme across our two main 2026 reviews and calls for a rethink re nomenclature of these conditions.

https://t.co/IVXcl4UKYS
@TheLancet

https://t.co/x26K2iOtne
@Brain1878

The autoantigen defines so so so much! It must be put at the center.

[CUpathology @CU_pathology]

Congratulations to our very own Ashley Denney (PGY4) who’s CAP Abstract on Microglial-Amplified Inhibitory Synaptopathy: Convergent Neuropathology in GlyR, GAD65, Kelch11, and NIF Autoimmunity was selected as the First Place Abstract at CAP 2026 🎉

[Frontiers - Neurology @FrontNeurol]

New Research: Clinical characteristics associated with GAD65 antibodies: a comparative study between high and low GAD65-ab cohorts www.​frontiersin.​org/articles/10.​3389/fneur.​2026.​1976777 #FrontiersIn #Neurology

[Long Covid Euskal Kolektiboa. @Euskalkolektibo]

A diferencia de la gripe y el virus repiratorio sincitial, el SARS-CoV-2 aún no ha consolidado un patrón estacional estricto ni predecible comportándose más como un virus social y continua manifestándose de forma ondulante.

@susanamcorella @_infoLibre
https://t.co/bMtJHguTyV

[Eric Topol @EricTopol]

My @scrippsresearch colleague @xinjin and her team are doing amazing brain biology discovery work with 2,000 agents, PerturbAI, in collaboration with @OpenAI
https://t.co/DZHc1Wv6An

[Senf Dazugeberin-Zwangsdurchseuchung beenden 9 💉 @dazugeberin]

Covid-Infektionen schädigen Gehirne und verändern das Verhalten der Menschen.

Auch bei denjenigen, die behaupten, es sei nur eine Erkältung gewesen.

https://t.co/WaQlwcEUfB

[REiCOP @_REiCOP]

¡Por fin tenemos fecha para la 3ª Jornada REiCOP!

🗓️ 27 de noviembre de 2026
📍 CaixaForum Madrid
🕘 9:30 - 18 h

🧬 Investigación, impacto en población pediátrica y apoyo laboral y social en una jornada única.

📄 Consulta el programa e inscríbete 👉🏼🔗 https://t.co/z1U94BbeRu

[Dylan Burnette @MAG2ART]

Another high profile paper showing the formation of blebbisomes from another cell type and not even a citation of the blebbisome paper...... Really???? My talk at AAEV next month is going to be fun for me........... https://t.co/OuHrgGZKs3

[Roger Gustafsson |bsk.social @RogerGustafsso2]

1/
Think COVID-19 is just a temporary respiratory bug?
A brand-new 2026 preprint study reveals how SARS-CoV-2 inflicts direct, lasting damage on the brain's microvascular system—even after mild infections. 🧵#FarUVC

[SENC @SENC_]

🧠 Desde la #SENC queremos dar la enhorabuena a Karl Deisseroth, Peter Hegemann y Georg Nagel, #NobelPrize de Medicina 2026, por sus descubrimientos sobre los canales iónicos activados por la luz y la #optogenética

🧵1/2

🔗https://t.co/cpxtwCeUn2

[rafael yuste @yusterafa]

Delighted to share that our former collaborator Karl Deisseroth wins Nobel Prize in Physiology or Medicine for optogenetics! https://t.co/wNdmEK5XHf

[Vipin M. Vashishtha @vipintukur]

#LongCOVID can cast a remarkably long shadow.

➡️ In this longitudinal cohort, 61% met criteria for post-COVID condition (PCC) at ~16 months, and 59% still did so at ~48 months.

Among those with PCC initially, an extraordinary 77% continued to meet criteria four years later. 1/

[John J. Millichap MD @JohnMillichapMD]

Clinical and imaging evolution of anti-GAD65-associated epilepsy: A clinical vignette https://t.co/YDV2A1Svc4 #Neurology #Epilepsy

[Vipin M. Vashishtha @vipintukur]

Could some #LongCOVID symptoms be driven by antibodies that turn against the nervous system?

➡️ Researchers found autoantibodies targeting proteins in the central and peripheral nervous systems in a subgroup of people with LongCOVID, particularly those with neurocognitive symptoms.

➡️ Remarkably, their IgG antibodies reacted with human brain regions and peripheral nerves, and some antibody levels correlated with neurological symptoms. 1/

[Sheila Macrine, Ph.D. @MacrinePhD]

California researchers have successfully integrated millions of human lab-grown neurons into modified mouse brains, creating a groundbreaking model to study complex neurodevelopmental disorders and brain injuries like epilepsy and cerebral palsy! 🧠🐭
https://t.co/2OvZnfbsvY

#Neuroscience #BrainResearch #StemCells #Neurology #ScienceNews #Stanford

[The Telegraph @Telegraph]

Human brain tissue has been transplanted into a mouse for the first time, creating a completely new hybrid animal.

Scientists want to use the human-mouse hybrids to study the biological causes of neurodevelopmental disorders such as schizophrenia, epilepsy, profound autism, cerebral palsy and dementia ⤵️
https://t.co/7h0uegFqap

[Giovanni Di Liberto @DiLibertoMD]

Inspiring work from @ThalerLab! Cladribine Treatment in a Retrospective Case Series in GAD65-Antibody–Associated Temporal Lobe Epilepsy | Neurology Open Access https://t.co/6WwzUPwbSR

[Dr. Nicole M. Fellouris, Ph.D, CISSP, ILO, SME, EH @DrNikkiPhDSME]

This is incredible!

[Mayo Florida AutoImmune Neurology Group @Mayo_AING]

Supportive of that view but……isn’t it amazing that only these #LGI1 #antibodies produce this phenomenon? So so so specific. The question is why. That’s the real dilemma to solve

[REiCOP @_REiCOP]

📊 Un informe de expertos integra las perspectivas de la investigación, la atención sanitaria y las personas afectadas por #COVIDpersistente para analizar las principales carencias y establecer prioridades de actuación
https://t.co/qSoHKhNvF5
#PostCOVID19
#SARSCoV2