Cristian Aparicio-Maldonado

Biochemist and Virologist. Currently challenging myself with a Molecular Microbiology PhD.
* Fan of multichannel pipettes

[Cristian Aparicio-Maldonado @_aparicioC]

@LethalCrysis Míratelo e infórmate mejor @LethalCrysis , porque sería un toque súper interesante al docu

[Cristian Aparicio-Maldonado @_aparicioC]

@LethalCrysis Por ello yo consideraría que la evolución ocurrió a nivel de especie humana. Evolucionamos a tener una gran capacidad de adaptación, y por eso vivimos en gran cantidad de ambientes y situaciones, al contrario que otros animales que son más especializados

[Cristian Aparicio-Maldonado @_aparicioC]

Tomorrow 27th January, I will defend my PhD at TUDelft at 12 pm(GMT+1).
My PhD research, entitled “DISARMing viral invaders of bacteria”, has been supervised by @StanBrouns and @NobregaFL

Feel free to join the public defense lifestream:
https://t.co/54y4SfblFz

#phd #defense

[Avraham Z. Cooper, MD 🩺 @AvrahamCooperMD]

This is a macrophage REPAIRING A BROKEN BLOOD VESSEL

#MedTwitter #biology

[Akos T. Kovacs @EvolvedBiofilm]

Superb Postdoc position possibility with @RikkeMeyer5 at @iNANO_AarhusUni on investigation of the properties of secondary DNA structures in the extracellular matrix of bacterial biofilms

https://t.co/xcM3gL8zjQ

[Raphael Hans Lwesya @rapher97]

Filamentous #phages have a low burden on bacteria and compensate by providing services that aid in the formation of better #biofilms , delivering toxins and other factors that increase #virulence, or modifying their behavior to pro…https://t.co/b04ZHI6VEV https://t.co/WTgAyusCuq

[Isabel M Argudo @isotopo1]

Programazo el viernes en Toledo!!! Gracias @BeM_Toledo por organizar esta jornada tan interesante!!

[Cristian Aparicio-Maldonado @_aparicioC]

@jpkbravo @NobregaFL @StanBrouns @davidwtaylorjr Congrats to you too Jack! it was a great and fun collaboration in a very exciting project! Hope there is more to come in the future 😃

[Jack Bravo @jpkbravo]

Congratualtions to my co-authors @_aparicioC @NobregaFL @StanBrouns @davidwtaylorjr. This was the first project I took on in the @davidwtaylorjr lab, and I'm really proud of the combination of cryo-EM, biochemistry and in vivo work we used to understand this fascinating system

[Jack Bravo @jpkbravo]

Excited to share the final version of our DISARM story! How can bacterial confer incredibly broad antiphage immunity and yet avoid immunity? We think the answer may be due in part to DNA structural context and other mechanisms for cryptic specificity.
https://t.co/to1YuBj1OU

[David Taylor @davidwtaylorjr]

Great work by my postdoc @jpkbravo @TexasScience and @_aparicioC and @NobregaFL out in ⁦⁦⁦@NatureComms!⁩ First exciting collaboration with @StanBrouns. Structure of a complex that can broadly DISARM phage by grabbing and reading ssDNA tails! https://t.co/zcZxo0jwTs

[Cristian Aparicio-Maldonado @_aparicioC]

@PeterFineran Congratulations Peter!

[Daan C. Swarts @DCSwarts]

This project was initiated by the magnificent @BalwinaK who carried out most of the work with @Potoc_A. Also many thanks to all other co-authors: @SumanthMutte @_aparicioC @StanBrouns, Simon Lindhoud and Jacques Vervoort.

Thanks @NWO_Science and @ERC_Research for funding!
11/11

[Daan C. Swarts @DCSwarts]

In eukaryotes, Argonautes (eAgos) are well known for their role in RNA-guided RNA interference.

Prokaryotes encode Agos (pAgos) but lack other RNAi components. Instead, certain 'long' pAgos use DNA guides to target and cleave invading DNA such as plasmids and viruses.
2/11

[Nils Birkholz @NilsBirkholz]

Very pleased to share our ✨New Paper✨ about an epigenetic conflict between a restriction–modification system and a methylation-dependent nuclease.

Want to know how that pans out? Continue reading here 🧵👇🏻 or head over to @NAR_Open for the full story: https://t.co/mKp6bvYUdw