We are looking for a Project Manager to facilitate a new program of work centered around a novel CAR T technology that will lead to a phase I trial & development of novel assets. Please see details below for role description and for further details.
Ever wondered why gamma delta T cells are required for immunity to liver-stage malaria?
Spoiler - they make IL-4!
@TheDohertyInst@NatImmunol
https://t.co/V42Dfn4upm
Our third webinar from the AUS/APAC region, will feature Nick Gherardin and Sho Yamasaki. Thursday, June 12th at 17:00 AEST (8:00 London, 16:00 Tokyo).
If you'd like to keep up to date, sign up to the mailing list here: https://t.co/MFOhQEgbLt
Our second webinar hosted from USA, will be by Laurent Gapin and Antonia Rotolo.
Thursday, February 6th at 16:00 GMT (8:00 Pacific, 11:00 Eastern, 1:00 Friday Tokyo)
If you haven't join, get updates and link here: https://t.co/MFOhQEgbLt
💪 New immunity research published in the Journal of Experimental Medicine highlights how the body keeps its prompt immune response in check. https://t.co/Te5mSNqDhZ
Authors: @_fernace, Prof Dale Godfrey, Dr Calvin Xu
@UniMelbMDHS @TheRMH
Selective regulation of IFN-γ and IL-4 co-producing unconventional T cells by purinergic signaling. New study from Calvin Xu, Dale Godfrey, Hui-Fern Koay @_fernace@TheDohertyInst @UnimelbMDHS and colleagues: https://t.co/qHAKEL154T
#LymphocyteBiology
Sharing our latest work @PNASNews
MR1 presents vitamin B6–related compounds for recognition by MR1-reactive T cells
We postulate that tumours' increased metabolism of vit B6 leads to elevated levels of pyridoxal and preferential recognition of tumours by pan-cancer T cells
see 🧵
We're incredibly stoked and honoured to have Fabio Grassi's commentary on our paper - this work has built on many of his team's findings and body of work, in the nexus of purinergic control of T cell activation and function! 🌟
Grassi @LaStatale discusses new study by Xu, @_fernace et al (https://t.co/6MMUEMiqJS) which defines NAD-induced cell death via purinergic P2RX7 receptor in type 1 unconventional T cells, particularly intrahepatic MAIT cells pivotal in liver homeostasis https://t.co/JaBD1JCzbn
Sharing our latest work @JExpMed! We've uncovered that P2RX7 regulates unconventional T cells selectively, particularly subsets that co-produce IFN-γ & IL-4. Hoping this helps more discoveries in the role of these innate-like cells, using inhibitors from the P2RX7/ARTC2 field!
In @JExpMed, Xu, @_fernace et al. @TheDohertyInst reveal that the ARTC2–P2RX7 regulatory axis is a key modulator of unconventional T-cell survival, showing how this pathway selectively influences innate-like, IFN-γ and IL-4 co-producing T cells. https://t.co/yJ1JXV8xiD
Conceptually, non-peer review'd diagram here: Within T cells at least, integrating thoughts posed by labs of P.Brennan, B.Jabri, perhaps the extent of tissue damage sensitivity could be a hallmark of the ‘T cell-innateness’ theory. https://t.co/vFbIRzk6HU
https://t.co/VIaVA2RSeX
Xu, @_fernace et al. @TheDohertyInst reveal that the ARTC2–P2RX7 regulatory axis is a key modulator of unconventional T-cell survival, showing how this pathway selectively influences innate-like, IFN-γ and IL-4 co-producing T cells. https://t.co/cojTCVlXtB
#LymphocyteBiology