Fern Koay 郭

👩🏼‍🔬🇲🇾🇦🇺🇺🇲🔬
Scientist in immunology @TheDohertyInst @UnimelbMDHS

[Prof Paul Beavis @paulbeavis4]

We are looking for a Project Manager to facilitate a new program of work centered around a novel CAR T technology that will lead to a phase I trial & development of novel assets. Please see details below for role description and for further details.

[Fern Koay 郭 @_fernace]

Untangling how γδ T cells kick-start CD8 immunity!

[Lynette Beattie @Lynette_Beattie]

Ever wondered why gamma delta T cells are required for immunity to liver-stage malaria?
Spoiler - they make IL-4!
@TheDohertyInst @NatImmunol
https://t.co/V42Dfn4upm

[ATP Tour @atptour]

Someone call a historian, this match is one for the BOOKS 📚

#RolandGarros #sinner #alcaraz

[CD1-MR1 Immunology @CD1MR1]

Our third webinar from the AUS/APAC region, will feature Nick Gherardin and Sho Yamasaki. Thursday, June 12th at 17:00 AEST (8:00 London, 16:00 Tokyo).

If you'd like to keep up to date, sign up to the mailing list here: https://t.co/MFOhQEgbLt

[CD1-MR1 Immunology @CD1MR1]

Our second webinar hosted from USA, will be by Laurent Gapin and Antonia Rotolo.
Thursday, February 6th at 16:00 GMT (8:00 Pacific, 11:00 Eastern, 1:00 Friday Tokyo)

If you haven't join, get updates and link here: https://t.co/MFOhQEgbLt

[Waggoner Lab @LabWaggoner]

Role for γδ T cell-derived IL-4 in initiating CD8 T cell immunity to Plasmodium
https://t.co/pjDdZfBRwp
@Lynette_Beattie

[Doherty Institute @TheDohertyInst]

💪 New immunity research published in the Journal of Experimental Medicine highlights how the body keeps its prompt immune response in check. https://t.co/Te5mSNqDhZ
Authors: @_fernace, Prof Dale Godfrey, Dr Calvin Xu
@UniMelbMDHS @TheRMH

[Journal of Experimental Medicine @JExpMed]

Selective regulation of IFN-γ and IL-4 co-producing unconventional T cells by purinergic signaling. New study from Calvin Xu, Dale Godfrey, Hui-Fern Koay @_fernace @TheDohertyInst @UnimelbMDHS and colleagues: https://t.co/qHAKEL154T

#LymphocyteBiology

[Wael Awad @WaelAwadMoh]

Sharing our latest work @PNASNews
MR1 presents vitamin B6–related compounds for recognition by MR1-reactive T cells
We postulate that tumours' increased metabolism of vit B6 leads to elevated levels of pyridoxal and preferential recognition of tumours by pan-cancer T cells
see 🧵

[Fern Koay 郭 @_fernace]

We're incredibly stoked and honoured to have Fabio Grassi's commentary on our paper - this work has built on many of his team's findings and body of work, in the nexus of purinergic control of T cell activation and function! 🌟

[Journal of Experimental Medicine @JExpMed]

Grassi @LaStatale discusses new study by Xu, @_fernace et al (https://t.co/6MMUEMiqJS) which defines NAD-induced cell death via purinergic P2RX7 receptor in type 1 unconventional T cells, particularly intrahepatic MAIT cells pivotal in liver homeostasis https://t.co/JaBD1JCzbn

[Fern Koay 郭 @_fernace]

@BjrnRissiek @JExpMed definitely an extension of the work with lots of ref'd papers from you and colleagues, thanks Björn!

[Fern Koay 郭 @_fernace]

Sharing our latest work @JExpMed! We've uncovered that P2RX7 regulates unconventional T cells selectively, particularly subsets that co-produce IFN-γ & IL-4. Hoping this helps more discoveries in the role of these innate-like cells, using inhibitors from the P2RX7/ARTC2 field!

[Rockefeller U. Press @RockUPress]

In @JExpMed, Xu, @_fernace et al. @TheDohertyInst reveal that the ARTC2–P2RX7 regulatory axis is a key modulator of unconventional T-cell survival, showing how this pathway selectively influences innate-like, IFN-γ and IL-4 co-producing T cells. https://t.co/yJ1JXV8xiD

[Fern Koay 郭 @_fernace]

@HBorgesdaSilva @JExpMed Thanks Henrique, learned a lot from your body of work!

[Fern Koay 郭 @_fernace]

Huge thanks to all our collaborators including @LMackayLab @Lynette_Beattie @JeffreyYWMak and those not on here, across @TheFlorey @UQ_News @UniMelbMDHS labs!

[Fern Koay 郭 @_fernace]

Conceptually, non-peer review'd diagram here: Within T cells at least, integrating thoughts posed by labs of P.Brennan, B.Jabri, perhaps the extent of tissue damage sensitivity could be a hallmark of the ‘T cell-innateness’ theory. https://t.co/vFbIRzk6HU
https://t.co/VIaVA2RSeX

[Journal of Experimental Medicine @JExpMed]

Xu, @_fernace et al. @TheDohertyInst reveal that the ARTC2–P2RX7 regulatory axis is a key modulator of unconventional T-cell survival, showing how this pathway selectively influences innate-like, IFN-γ and IL-4 co-producing T cells. https://t.co/cojTCVlXtB

#LymphocyteBiology