International Natural Product Sciences Taskforce

#INPST aims to promote science communication and collaborative research, with focus on: #Medicine, #Science, #SciComm, and #Health. Administered by @_atanas_.

[International Natural Product Sciences Taskforce @_INPST]

The excellent outcome of #INPST-based collaborative work

#NaturalProducts #DrugDiscovery
By: @_INPST @_atanas_ @univienna @LBG_research @FrancescaGiamp5 @Bio_Lab_UNIVPM @DHPSP @maciejbanach @ilkay_E_ORHAN @BgSciencesBAS @docmmiller @UNI_FIRENZE @NatRevDrugDisc @MedUni_Wien

[Nature Reviews Drug Discovery @NatRevDrugDisc]

Natural products in drug discovery: advances and opportunities - a new review published today from @_INPST https://t.co/UwepAfRdpH @_atanas_ Readcube version https://t.co/QxV8TiGW26

[Atanas G. Atanasov @_atanas_]

@readswithravi

[Atanas G. Atanasov @_atanas_]

Hepatitis B control after treatment ends? FDA-approved Hibsago offers that possibility for certain adults without cirrhosis. A 24-week trial result, with serious risks requiring monitoring.

https://t.co/qBBhVQu4Up

[Atanas G. Atanasov @_atanas_]

“Metabolic and neural responses to ultraprocessed foods: a randomized, controlled, crossover study.” Published October 05, 2026, Nature Metabolism
https://t.co/MBwxav3m7t

[Dr Alexey Kulikov @KulikovUNIATF]

A new @WHO report reveals that noncommunicable #NCDs diseases like cancer, heart disease, and diabetes, along with their risk factors, disproportionately impact the poorest and most disadvantaged populations within countries.

This first comprehensive global assessment highlights that people with lower education and income often face higher risks from #tobacco, alcohol, and #airpollution, and frequently receive worse care, such as lower cancer screening rates and less access to hypertension treatment in rural areas.

To close these unjust gaps, countries must prioritize equity-oriented policies, strengthen primary #health systems, and invest in collecting better disaggregated data to ensure that life-saving interventions actually reach the populations most in need.

https://t.co/Yt9YzzLzgK

[MECFS, MCAS and PTSD @FatigueMe92484]

FT mice exhibited restored circadian rhythmicity of hepatic SIRT1 and PPARα protein expression compared to the disrupted patterns in FA mice,

https://t.co/9fIhn3R09Y

[Ricardo Montes T @RicardoMTorr]

Circulating vitamin D metabolites are distinctly associated with all-cause and cardiovascular mortality: a prospective study

✅️ Higher 25(OH)D3 levels were associated w/lower risks of all-cause & CVD mortality, whereas 25(OH)D2 showed no significant associations w/mortality.

Highlights:

▶️ Serum 25(OH)D₃ was associated with lower risk of all-cause & CVD mortality.

▶️ A nonlinear association was observed between 3‑epi-25(OH)D3 & mortality.

▶️ Serum 25(OH)D₂ was not significantly associated w/mortality.

▶️ Alkaline phosphatase & albumin may mediate 25(OH)D₃-mortality associations.

https://t.co/LhVq26YFr8
@Mangan150 @ScienceCommuni2 @_atanas_ @DrRPalmquist @nuclearball @drfherediaz @guani_vic @chidambara09 @FarmerJeff252

[Kelly Anderson @kelly_archives]

Endogenous GLP-1 peptides may help protect the gut from immune-mediated damage by reducing inflammation and supporting mucosal repair. These findings reinforce their potential role in maintaining intestinal health and barrier integrity. #healthcare

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

Meal timing as medicine: clinical evidence for intermittent fasting in Huntington's disease

"to our knowledge, the first clinical evidence that time-restricted eating is feasible in people with HD and may influence disease-relevant clinical and biological measure"

https://t.co/em3wRbM2AU

[Sarah Clark @SarahClarkBDM]

The 35% rise in net launch prices for new prescription drugs highlights growing concerns about medication affordability and access.

#DrugPricing #HealthcareCosts #PatientAccess #HealthcarePolicy #AHAToday

[Dr Alexey Kulikov @KulikovUNIATF]

Germany 🇩🇪 is raising taxes on cigarettes, sugary drinks and #alcohol in a push expected to generate billions of euros for state coffers while promoting public health.

Lawmakers approved a sharp rise in #tobacco taxes on Thursday, expected to raise more than €12 billion in 2027–2030 and push the average pack above €11 by the end of the decade.

A day earlier, the cabinet approved a #sugar levy on soft drinks 🥤 from July 2027: €0.26 per litre for drinks with at least 5 g of sugar per 100 ml, rising to €0.32 for higher-sugar products.

The finance ministry expects €690 million in 2027 and €925 million in 2028, against about €2.1 billion a year in healthcare costs linked to sugary drinks. Duties on spirits, sparkling wine and alcopops are set to rise by 20% from 2027, though beer and still wine are left untouched.

A strong step in the spirit of @WHO “3 by 35” initiative. Better #health and sustainable revenue for health systems can go hand in hand.

https://t.co/isT6Ggdi25

[Sergey Minaev @sminaev2015]

Childhood Inguinal, Femoral, and Abdominal Hernias in Low-Income Countries: Trends, Inequalities, and Projections to 2050 #some4pedsurg #some4surgery https://t.co/VYVifJuWib

[Ricardo Montes T @RicardoMTorr]

Study on blueberries, protein & exercise for improving frailty & cardiovascular disease (STRONG)

https://t.co/1Ngm90Zf3k @_INPST @Mangan150 @nuclearball
@DrRPalmquist

The STRONG intervention: Combining protein, blueberries & resistance/aerobic exercise may reduce frailty & improve CV health, further reducing frailty.

[sciqst @sciqst]

Your DNA could change your prescription. 🧬

In 2025, scientists delivered the first personalized CRISPR treatment to an infant with a rare genetic disorder just 6 months after diagnosis [1].

Meanwhile, NIH research identified 275 million previously unreported genetic variants, opening new paths to precision medicine [2].

💊 The opportunity is enormous: fewer ineffective treatments, better drug selection, and earlier disease detection.

But access remains unequal. Over 90% of participants in major genomics studies have European ancestry [3].

Healthcare leaders must invest in diverse datasets, affordable testing, and genetic counseling.

🤔 Should genetic testing become routine healthcare, or could it deepen existing inequalities?

[1] [https://t.co/c5IdgSim7K](https://t.co/VlD5A96N4S)

[2] [https://t.co/ajyyBTzdCQ](https://t.co/2jC1cq5JtJ)

[3] [https://t.co/qbiLpXKxXN](https://t.co/sj9PVVHXO8)

#GeneticTesting #PrecisionMedicine #Genomics #HealthEquity

[Palm Garden @PalmGardenHC]

Good Wednesday morning. Here's to a wonderful day.
#CelebratingLifeStories #WeArePalmGarden

[MECFS, MCAS and PTSD @FatigueMe92484]

2′-Fucosyllactose enhances indole-3-lactic acid production by Bifidobacterium bifidum DNG-08 and alleviates colitis-associated bone loss: Associations with microbiota remodeling and intestinal AHR-related responses
https://t.co/0a9A3QMYgU

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

From self-quantification to predictive ageing: Digital twins as a framework for healthy ageing and longevity

🗣️"A prominent example is the Blueprint project generated by Bryan Johnson (Johnson, 2024), which integrates repeated measurements across metabolic, cardiovascular, inflammatory, functional, imaging and epigenetic domains..."📊

👨‍⚕️Re: @bryan_johnson: "We propose a digital twin framework that models healthy ageing as a latent dynamical system rather than static biomarkers..."

https://t.co/wcwShONNWN

[Yüksel Ürün @DrYukselUrun]

A breakthrough that patients cannot access is an unfinished breakthrough. SEOM and ESMO are right to challenge barriers to clinical trials. Will Europe turn this commitment into action?
@myESMO @_SEOM @Ecastromarcos @FAndreMD @curijoey #ESMO26

[Kelly Anderson @kelly_archives]

Advances in cardio-oncology are essential to protecting cardiovascular health while preserving the effectiveness of cancer treatment.

#CardioOncology #CancerCare #Cardiology #MedicalResearch #HealthcareInnovation

[Dr. Eddie Ramirez @EddieRDMD]

Toward an Optimal Diet for Health in Asia: The Asian–Mediterranean Dietary Pattern
迈向亚洲人群的健康优化膳食：亚洲-地中海膳食模式
https://t.co/IIqm6P5erg @didengshengwu

[Kristie Leong M.D. @DrKristieLeong]

Muscles do more than move your body. They help suppress tumors.
-
A new Nature Communications study exposed a striking muscle-to-tumor signaling pathway.

The biology:

1. Muscle sends messages: healthy muscle releases extracellular vesicles - tiny packages carrying molecular cargo.

2. One microRNA, miR-7a-5p, suppressed cancer-cell growth by targeting TEAD1, a protein involved in tumor proliferation.

3. Aged muscle produced fewer vesicles with less tumor-suppressing cargo.

4. Exercise restored the signal:

iin older mice, exercise activated the Notch → SDC2 pathway, increased vesicle production and slowed tumor growth.

5. Block the pathway: the exercise-associated tumor suppression disappeared.

This is not proof that exercise prevents cancer in humans.

The experiments were primarily in mice and cells.

But they reveal something important:

Muscle isn't just machinery.

It's an endocrine organ sending biological signals throughout the body.

Your move: Build muscle. Keep using it.

Give yourself another reason to resist age-related muscle loss.

Ref: Nat Commun, 2026; doi:10.1038/s41467-026-72410-y