New sensor to not only detect viruses but also determine if they are infectious! Our aptamer-nanopore sensor work is out in @ScienceAdvances! https://t.co/vSNSmnRVtN
@MarcioDiasgroup@LatinXChem It is known that this protein is involved in RSS detoxification mechanisms that in high concentrations become toxic to the pathogen, as well as in the formation of biofilms. Of course it would be an ideal protein to design antimicrobials!!!
@MarcioDiasgroup@LatinXChem Hey Marcio!! That's a great question! As can be seen in one of the figures, virulence genes are distinguished in RNAseq that are regulated, directly or indirectly, by BigR.
@emedemaur @LatinXChem Although the reason for this effect is unknown, we suppose that it could be due to nonspecific binding of the protein with fluorophore.
@emedemaur @LatinXChem Thank you Mauro for you question!We do not believe that the drop in fluorescence anisotropy is significant. Similar results were obtained in previous experiments, with a constant drop in anisotropy.
@Ceci_Ortiz_uy@LatinXChem Por lo tanto, es razonable pensar que esto esté relacionado con la producción endogóna o exógena de RSS, que suelen ser beneficiosas en estas condiciones.
@Ceci_Ortiz_uy@LatinXChem La formación del biofilm es un mecanismo que tienen algunos patógenos para resistir a los ambientes hostiles, y permear selectivamente nutrientes, excluyendo las ROS producidas por el huésped.
@Ceci_Ortiz_uy@LatinXChem Hola Cecilia! Muy interesante tu pregunta! Todavía no tenemos una respuesta definitiva pero es algo en lo que seguimos trabajando.
Hi @LatinXChem, i'm really happy to share with everyone my reaserch "Structural adjustment of Calreticulin C-terminal domain with calcium and molecular crowders". #LatinXChem#LXChemBio#BIO027.