Ranabir Chakraborty

Post-Doc, BIG centre, UVA. Previously at Institute Pasteur, Paris

[Ranabir Chakraborty @_ranabir]

Super happy to see the final version of our study online. What started as a summer project in 2023 culminated into this, wherein we assessed the basis of directional α-Synuclein transfer from neuronal cells to microglia
https://t.co/alYSSxeSvu

[Ranabir Chakraborty @_ranabir]

@_AishPrakash Thanks Aishwarya 🙌🏼

[Ranabir Chakraborty @_ranabir]

Super happy to see the final version of our study online. What started as a summer project in 2023 culminated into this, wherein we assessed the basis of directional α-Synuclein transfer from neuronal cells to microglia
https://t.co/alYSSxeSvu

[Ranabir Chakraborty @_ranabir]

@Reza_Hashim21 Thank you hashim Bhai 🙌🏼

[Waggoner Lab @LabWaggoner]

Mitochondria acidify lysosomes through membrane contacts @uofcincy @SunLabUCin
https://t.co/T8USqpuJs7

[Ranabir Chakraborty @_ranabir]

@Reza_Hashim21 Thank you Hashim Bhai:)

[Ranabir Chakraborty @_ranabir]

Happy to share our work (final aspect of my thesis). We tried to understand why neuronal and microglial cells upregulate TNTs in the presence of α-Synuclein aggregates? Turns out inflammation has a major role to play in the process! https://t.co/Vyr3igP6bY

[Ranabir Chakraborty @_ranabir]

@LukensJohnR Thank you so much, hope it was/will be a fun read:)

[Ranabir Chakraborty @_ranabir]

Massive thanks to @Veronicatesta96 , Jara Montero-Munoz, and @ConsiglioLab for a fruitful collaboration. It was amazing working together

[Ranabir Chakraborty @_ranabir]

We now have an updated version of this story - new experiments and analysis added!

https://t.co/gDS83E5TvK

[Ranabir Chakraborty @_ranabir]

Delighted to share a second part of my Ph.D. work. As a follow-up of our previous observations, we wanted to understand the reason behind directionality of aggregate transfer between neuronal cells and microglia. https://t.co/XFTJWNHnT5

[Ranabir Chakraborty @_ranabir]

@LukensJohnR @kzengeler Congratulations everyone, super cool work!

[Brain-Immune Communication Lab @AleksDeLab]

And it's out! The BIC lab presents our new perspective article on "Immune Control of Brain Physiology" - fresh off the press at @NatRevImmunol https://t.co/WgTcbrUsOF
wonderful synergy @_marikovacs @Ali_MoussaSamir and twitterless Amaia Dominguez-Belloso.

[Michael Connor @midweekwarrior]

It's here! I'm recruiting a #postdoc to work with me on an ANR funded project @institutpasteur! Check it out! We're in @Chrom_Inf & @BCI_Pasteur

[Guillaume Frasca @G_Frasca]

Great @BCI_Pasteur retreat in sunny Cap Esterel with amazing science and passionate people 🥳

[Ranabir Chakraborty @_ranabir]

@NathalieRouach Congratulations @NathalieRouach , great news :)

[Ranabir Chakraborty @_ranabir]

@shamitkumar6 Congratulations @shamitkumar6 , @tusar_acharya , @CGLab_NISER , great work!

[Ranabir Chakraborty @_ranabir]

@Chrom_Inf Congratulations, this is fantastic:) @Chrom_Inf

[Ranabir Chakraborty @_ranabir]

@DsilvaGreg Thanks Greg!

[Ranabir Chakraborty @_ranabir]

Delighted to share a second part of my Ph.D. work. As a follow-up of our previous observations, we wanted to understand the reason behind directionality of aggregate transfer between neuronal cells and microglia. https://t.co/XFTJWNHnT5

[Ranabir Chakraborty @_ranabir]

@RayA28s Thank you @RayA28s da

[Ranabir Chakraborty @_ranabir]

@VidyadharDJ Thank you @VidyadharDJ

[Ranabir Chakraborty @_ranabir]

Had a great time working with with Philippa on this story, with fantastic support from @ZurzoloLab

[Ranabir Chakraborty @_ranabir]

Consequently, autophagy flux was inhibited in neuronal cells (and not in microglia). We hypothesized that autophagy dysfunction could be one of the reasons for directional aggregate transfer, and it indeed was.