Ahmet Acar

Associate Professor @METU_ODTU. Previously @ICR_London, @OfficialUoM, @CRUK_MI, @WhiteheadInst. #cancerevolution #genomics #drugresistance #tumororganoids.

[Ahmet Acar @acarahme]

📢 A new publication on patient-derived tumor organoids (PDTOs) from our group is now out. I discussed recent advances, current applications, and future directions of organoids in cancer research and precision medicine.
👉 Read here: https://t.co/atC4FCcu5B

[Ahmet Acar @acarahme]

🧠 Expressible barcode analysis for lineage tracing and single-cell RNA-seq in BI-2865-resistant PDOs, developed ex vivo, reveal genotype-dependent clonal trajectories and multiple resistant cell states rather than a single convergent program.
(3/3)

[Ahmet Acar @acarahme]

🚨 New bioRxiv preprint out! 🚨

In this study, we introduce a living biobank of patient-derived organoids (PDOs) from 20 metastatic colorectal cancer patients that captures both inter- and intratumoral heterogeneity across diverse KRAS genotypes.
https://t.co/oKVliA3iQW
(1/2)

[Ahmet Acar @acarahme]

Key findings:
🔬 KRAS genotype strongly shapes drug response phenotypes in PDOs.

🧬 Resistance to the pan-KRAS inhibitor BI-2865 in PDOs is driven primarily by transcriptional plasticity, not widespread genomic change

1/2

[Cancer Research @CR_AACR]

New in the December 15 issue from the Cancer Research special series: A Roadmap for the Future of #SystemsBiology in Cancer Research, by Aaron S. Meyer and colleagues https://t.co/EFsoEKu8tK
@hghmkin @sandhya212 @Clarararara_hu @Luddyka @jhxing001 @acarahme @SongZhimuFeng

[Ahmet Acar @acarahme]

I invite you to explore the collection.
https://t.co/EZPLVZesj9

[Ahmet Acar @acarahme]

I’m excited to share that I am acting as Guest Editor for the Methods Collection “Advancing Precision Medicine Through Patient-Derived Organoids: Standardized Methods and Emerging Applications” published by JoVE.
https://t.co/EZPLVZesj9

[Ahmet Acar @acarahme]

🎉 Our new paper in FEBS Letters reveals that reversible irinotecan resistance in LIM1215 colorectal cancer cells is driven by phenotypic plasticity and drug efflux - read more here:

https://t.co/DIknZBL8p7

[Ahmet Acar @acarahme]

Excited to see “A Roadmap for the Future of Systems Biology in Cancer Research” finally out in Cancer Research @AACR Journals! A big step forward in shaping how systems biology can transform our understanding and treatment of cancer.

https://t.co/7Kf49D6D4A

[Ahmet Acar @acarahme]

Excited to be attending the Disease Modeling and Therapeutics conference at @SidraMedicine in Doha, Qatar—an incredible opportunity to exchange knowledge and explore innovative approaches in healthcare.

[Ahmet Acar @acarahme]

Öykü and Gamze was supported by our @tusebgovtr B project.

Congratulations to all three on their achievements! 👏

[Ahmet Acar @acarahme]

This week, we celebrated three recent graduates from our group who successfully defended their theses. 🎓✨
1. Hakan Berk Aydin, co-supervised with Dr. Altuğ Özçelikkale from the Department of Mechanical Engineering.
2. Öykü Yağmur Başar
3. Gamze YILMAZ

[Ahmet Acar @acarahme]

Very happy to be part of this fantastic paper led by a great team 🙌👏

[Andrea Sottoriva @AndreaSottoriva]

What's heritable and what's plastic in cancer drug resistance? The two are linked! (Epi)genetic molecular memory is under Darwinian selection but encodes multiple plastic phenotypes. We found this with organoid experimental evolution + ML for multiomics. https://t.co/nrjtgAuET9

[Ahmet Acar @acarahme]

Very excited to be part of this meeting and look forward to sharing our latest research. Special thanks to Dr. Gulnihal Ozcan for the kind invitation.

[Ahmet Acar @acarahme]

Davet için teşekkürler ve yarın görüşmek üzere!

[Bingöl Üniversitesi Proje Koordinasyon UA Merkezi @BU_PKM]

Bilim Söyleşileri serimizin ikinci etkinliğinde, alanında ulusal ve uluslararası başarılarıyla öne çıkan Doç. Dr. Ahmet Acar’ı konuk ediyoruz. #proje #bilim #araştırma
📅Tarih: 6 Mayıs 2025
⏰Saat: 11:00
📍Platform: Microsoft Teams
🔗Bağlantı linki: https://t.co/KucxdKZTNo

[Ahmet Acar @acarahme]

ODTÜ’de doktora başvurusu yapmadan önce, lütfen neden ekibimize katılmak istediğinizi açıklayan kısa bir bilgi notu ve güncel özgeçmişinizle birlikte [email protected] adresine e-posta gönderiniz.

[Ahmet Acar @acarahme]

Kanser biyolojisi, tümör organoidleri ve hesaplamalı biyoloji alanlarına ilgi duyuyorsanız ve disiplinlerarası araştırmalara meraklıysanız, sizi ACAR Lab'a (https://t.co/xNGpKqmMtN) bekliyoruz.

[METU / ODTÜ @METU_ODTU]

ODTÜ’de yüksek lisans ve doktora başvuruları başladı.

Bu, sadece bir başvuru değil, araştırma yolculuğuna bir davet.

2025/2026 Güz Dönemi başvuruları ve detaylı bilgi için:

https://t.co/w9ZDjQcccR

https://t.co/jg6EBcVYm0

[Ahmet Acar @acarahme]

Pleased share our recent publication led by our talented graduate student Safa Kerem Aydin with the invaluable support of Kubra Celikbas Yilmaz

https://t.co/Qi96upMufh

[Ahmet Acar @acarahme]

@rguendogdu @EsashiLab @TubitakBIDEB @bingoledu2007 @ercelik2000 @Tubitak @UniofOxford Congratulations 🙌

[Ahmet Acar @acarahme]

1. Uluslararası Herediter Kanserler Kongresi tum hızıyla Prof Hakan Akbulut’un Türkiye’de ve bölgede öncü rol üstelenen @AnkaTheraHub sunumu ile devam ediyor. Muhteşem program için teşekkürler @DrYukselUrun @ozdogan_md @presicionhealth