Cassidy Pfaff

Blonde. Shiba. Married. Mom. Cardiovascular Pharmacist in Oklahoma. she/her/Dr.

[Pablo Corral MD @drpablocorral]

👉 Combination Lipid-Lowering Therapy After ACS: Should this be the New Standard of Care?

👆 LDL-C reduction after ACS shows a log-linear relationship with CV risk reduction, regardless of the drug used. Lower is better. Earlier is better.
👆 Guidelines have moved: ESC/EAS and ACC/AHA now endorse earlier and deeper LDL-C lowering, including upfront combination therapy in selected (or many) patients.
👆 Real life hasn’t caught up: <20% of post-ACS patients reach LDL-C <55 mg/dL. The stepwise “wait-and-see” model fails—predictably.

📍 Evidence is consistent:
IMPROVE-IT, RACING, LODESTAR → combination therapy works, is safe, and improves goal attainment.
ODYSSEY OUTCOMES, FOURIER → add PCSK9 inhibition and events drop further, especially when started early.

📍 Imaging doesn’t lie: PACMAN-AMI and HUYGENS show faster plaque regression and fibrous-cap thickening with early intensive therapy.

📍 Registries (SWEDEHEART, INTERASPIRE): early statin + ezetimibe beats late intensification or statin alone—both for LDL-C targets and hard outcomes.

👆 Fear of “too low LDL-C” is obsolete: benefits persist down to ~20 mg/dL, with no signal for harm. Cholesterol biology is robust; atherosclerosis is not.

📍 Bottom line:
After ACS, default early combination therapy (high-intensity statin + ezetimibe) is not aggressive—it’s rational. Precision medicine is great, but undertreatment kills first.

🔗 Open Access https://t.co/AkTlEYCnyg

@society_eas

[Charli @charli_xcx]

kamala IS brat

[Cassidy Pfaff @acassidything]

@clairezagorski @SyringeAccess Exactly what I was going to say 😂

[Auntie Pho, MD 🍲🏳️‍🌈👨🏻‍⚕️🟧 @AuntiePho88]

@katewillett @J_sketchez Nothing to see here just some misogyny on full display.

[Cassidy Pfaff @acassidything]

@TheFlightDeal @TrishaLepa

[Cooper @Cooperstreaming]

Just for some context, these two are the same ages as Leonardo DiCaprio &amp; his new girlfriend

[Samira Zantout @samirazantout]

No. There is no shortage of pharmacists/technicians. What we have is a shortage of safely staffed, respected, and properly compensated community pharmacy positions that do not drive employees directly to burnout.

[Cassidy Pfaff @acassidything]

Should I move to Boston or no?

[Cassidy Pfaff @acassidything]

After 6 years, I finally convinced my husband to get an iPhone. Hallelujah

[Cassidy Pfaff @acassidything]

@linbeezy14 I used to get Botox at Premier Derm in Fayetteville and I like them! I think my injectors name is Adrienne

[Cassidy Pfaff @acassidything]

I thought I knew pain until I spent 45 minutes lovingly crafting a dinner for my child who did not eat even a single bite

[shar @sharloola]

i’ve been forced to watch some football recently and i really think they should consider editing the matches to have confessionals from the players like in reality tv shows. would be way more interesting

[maya 🪩 @allmychampagne]

Either boys liked you in high school or you got a Taylor swift verified fan presale code there is no crossover

[Cassidy Pfaff @acassidything]

My mom cannot hear a single story about anyone without knowing what their zodiac sign is

[Cassidy Pfaff @acassidything]

Not Taylor swift and paramore 😭😭

[Taylor Swift @taylorswift13]

I’m enchanted to announce my next tour: Taylor Swift | The Eras Tour, a journey through the musical eras of my career (past &amp; present!) The first leg of the tour will be in stadiums across the US, with international dates to be announced as soon as we can!
https://t.co/KFuqvrhSGo

[Cassidy Pfaff @acassidything]

My husband was making fun of the tarot cards I bought on a whim on a bachelorette trip and he did a gag where he pretended to “read my fortune” and then he pulled THE EMPRESS card for my reading 👸🏼

[Tig Notaro @TigNotaro]

excuse me, bartender, can I get a double Sleepytime tea, neat?

[Elizabeth Warren @ewarren]

It’s here! You can now apply for student debt cancellation from the Biden administration—and it only takes a couple of minutes:
https://t.co/TvwENHxRBb