Alistair Coulstock

Bridging strategic vision with actionable sustainability, empowering organisations to achieve ambitious and resilient goals.

Inspire | Innovate | Ideate

[Alistair Coulstock @acoulstock]

@Midtownhome2 @StoxPlexShubham @grok The MiC won...😞

[Died Suddenly @DiedSuddenly_]

And now you understand why people have “gluten intolerance” and why the average age of cancer diagnosis has plummeted.

[Captain Johnno @cptcapt]

Great to see an Aussie comedian give an articulate POV on what is happening with the economy ATM.

Interesting fact about Luke is he holds a bachelors in economics, Dave Hughes can't even hold his bladder so pisses into @meladoodle glass.

##auspol

[Valerie Anne Smith @ValerieAnne1970]

RFK Jr. exposes why Gluten Allergies skyrocketed...

“2006 marks the date when suddenly these gluten allergies began exploding... celiac disease & wheat problems... you can draw a red line: 2006—the year they began spraying GLYPHOSATE on wheat as a DESICCANT.”

[Alistair Coulstock @acoulstock]

@SnowBrains Crackenback. Won't forget that name. Or in my case Crackenknee...

[Alistair Coulstock @acoulstock]

@loadingalias @hilbertspaess @robbensinger It also assumes that AI is going to have the same shitty and greedy morals as humans...
A massive assumption.
If it is going to be destructive then why won't it take out all other species in this planet.
Then you have to ask, to what benefit...
It's a dumb take.

[Alistair Coulstock @acoulstock]

@YourFavWV Gluten caused my sinus issues.
Quit gluten

[The opinionated Black woman ~ Aunty @Theblackfemini3]

Standing Ovation for this wonderful masterpiece that really let's our leaders know just how much we appreciate their efforts in running our countries.

BRAVO ladies, such a beautiful song!
👏👏👏👏👏👏

[David Shoebridge @DavidShoebridge]

🚨🚨🚨BREAKING: ASIO no. 2 is being rushed through parliament this week.

This is the bill that allows warrantless questioning by ASIO, without a lawyer, and you can't tell a soul without being sent to prison.

Share this widely and make some noise.

[Danny Jones @JonesDanny]

"If you spend the $1.50 it takes to build this, you will be rewarded with this pulling itself through space."

NASA scientist Dr. Charles Buhler & 40 year space program veteran Andrew Aurigema demonstrate their fuel-free thruster:

[Joseph Ferris ( Boopsy) @bupc_boopsy]

Grown man desire
#GenX #1972s

[Kris Luckenbach @KrisLuckPhoto]

A video I captured I think everyone should see

[Monsieur Gregg 🇿🇦 @g_mapaya]

This is crazy

[The Sigma Mindset @thesigmamindset]

There are only two ways to be successful…

[Boiler Man 🇺🇸🇺🇸🇺🇸🇺🇸🇺🇸 @Boilerman2019]

Mother fuckers are stealing everything!!

[Yasmine Khosrowshahi @yasminekho]

10 years ago, Tim Ferriss walked into Google & revealed exactly how to cage the monkey mind that is destroying your life every passing day:

1. The real training is in the small embarrassments. We do not rise to the level of our hopes. We fall to the level of our training. If you cannot handle small moments of public embarrassment you will not have the backbone to make big decisions under real pressure.

2. Seneca practiced poverty once a month. He would wear rough clothing, eat the simplest food, and ask himself is this the condition I so feared. Tim does one three day water fast every month and one seven to ten day fast every quarter for the same reason. Once you know the worst case is survivable you stop fearing it.

3. The monkey mind is not a dialogue. It is a stern and irritating roommate in your head that never shuts up. The morning journal is not about producing writing. It is about giving that roommate a two dimensional prison so it stops playing on repeat for the rest of the day.

4. The Five Minute Journal takes two and a half minutes in the morning and two and a half at night. The morning portion is a gratitude and planning exercise. The evening portion is a performance review. The ROI on those five minutes is higher than almost anything else Tim does.

5. Depression is an obsession with the past. Anxiety is an obsession with the future. High achievers almost always skew toward anxious future focus. Without a deliberate gratitude practice they hit goal after goal and feel nothing because they are already racing toward the next one.

6. The single biggest difference between the top quartile of performers and the top one percent is the degree to which they can identify their goals and maintain focus on them. Everything else is secondary to that one thing.

7. Humility does not require willpower. It requires designing the right environment. Every day Tim tries to be the weakest person in the room at something. At 15 in Japan he thought he was a judo star until a guy forty pounds lighter destroyed him in seven seconds. Then he trained at a school that produced Olympic gold medalists and got demolished by twelve year olds for months. He came out the other end completely transformed.

8. More than eighty percent of the world class performers Tim has interviewed across every field have a daily meditation practice. Some do not call it meditation but they all have something that functions the same way. Amelia Boone, the greatest female obstacle racer alive, sings the same song to herself on loop for hours. Arnold Schwarzenegger did transcendental meditation for a year and said the benefits persisted for decades after he stopped.

9. A high percentage of the successful men Tim has interviewed over fifty skip breakfast entirely. Pavel Tsatsouline, the man who brought kettlebells to America, answered what did you have for breakfast with a single word. Coffee.

10. What matters is not having a specific routine. It is having a routine. Whatever it is. The goal is to preserve your decision making and creativity for the things that actually require them. Steve Jobs wore the same thing every day. That was not a fashion choice. It was an energy allocation strategy.

11. Tim treats his entire life as two week experiments and six month projects. A reliable five year plan almost by definition requires you to set goals below your current capabilities. He is unwilling to do that so he does not plan that way.

12. The most successful people he has interviewed are not naive optimists. They budget for the downside. Richard Branson's real skill is figuring out the maximum he can lose and the maximum time he can lose before committing to anything. Once you realize the worst case is reversible the risk disappears.

13. The podcast succeeded because Tim knew he had a guaranteed audience of one. He was building something he could not find anywhere else. Every book came from the same place. When designing for a market things fail. When solving his own problem things work.

14. He committed to doing six podcast episodes before deciding whether to continue. If you only do one you will quit. The learning curve does not hockey stick until at least six. The survival of the project depended entirely on that pre-commitment.

15. Email is not a priority system it is other people's priority system for your time. Tim batches email offline so he is not doing whack-a-mole where sending two emails generates five back. He also uses if-then lines in every email he sends. It takes thirty extra seconds and eliminates twenty rounds of back and forth.

16. Never attribute to malice what you can attribute to incompetence or busyness. Holding a grudge about someone not replying means you are carrying imaginary shrapnel like acid in a vessel. You are the only one harmed by it.

17. For longevity Tim does regular extended fasting to purge precancerous cells combined with hyperbaric oxygen at two and a half atmospheres three times a week. By forty almost everyone has precancerous cells. The goal is not uncontrolled growth and fasting addresses the metabolic conditions that allow that.

18. For insomnia the two things that helped him most were morning meditation to quiet the machinery before the day starts and reading fiction before bed to shift from problem solving mode into story consuming mode. The monkey mind cannot solve problems it does not know it is supposed to be solving.

Follow @yasminekho for more ideas on thinking better, becoming clearer & building a more intentional life.

[Alistair Coulstock @acoulstock]

@jack_9947 SaaS

[Joe Tippens @JoeTippensl]

Ivermectin and Mebendazole in Cancer Patients

The Clinical Benefit Ratio

Complete Response + Partial Response + Stable Disease / Total Patients

(CBR) was 84.4%

Overall, it is estimated that annual costs of standard chemotherapies average $111,000 per year.

Background: Drug repurposing offers a pathway to identify accessible, low-toxicity cancer therapies.

Ivermectin and mebendazole have demonstrated multi-target anti-cancer activity.

This paper evaluates real-world patient-reported outcomes, safety, and adherence in a cohort of cancer patients utilizing this combination protocol.

Methods:

Prospective observational cohort of 197 cancer patients,

who were prescribed ivermectin and mebendazole off-label through telemedicine (platform by licensed U.S. healthcare providers)

Participants received compounded oral capsules containing 25 mg ivermectin and 250 mg mebendazole.

Data were collected via voluntary, standardized digital surveys at baseline and at approximately 6-month follow-up.

Of the initial cohort (N = 197), baseline characteristics, including cancer type and disease status, were assessed.

A total of 122 participants completed the follow-up survey (61.9% response rate)

Results:

Mean age of 67 years, (52.3% male, 47.7% female).

Cancer types included
Prostate 27.9%
Breast 18.3%
Lung 8.6%
Colon 5.1%
Urologic 4.6%
Pancreatic 3.0%
Liver 2.5%
Gynaecologic 2.5%
Hematologic 2.5%
Median duration since initial diagnosis, 1.2 years

37.1% experiencing active disease progression.

6-month follow-up

Medication adherence, 86.9%

Full initial 90-capsule ivermectin-mebendazole prescription.

The Clinical Benefit Ratio

Complete Response + Partial Response + Stable Disease / Total Patients

(CBR) was 84.4%

Notably, 48.4% of cohort, strongest positive outcomes:

Regression, 15.6%

No current evidence of disease (NED), 32.8%

Disease stability, 36.1%

Disease progression, 15.6%

No significant dose-response association was observed for cancer outcomes (p = 0.91),

without a clear dose-response gradient for efficacy.

Side effects

Mild side effects (primarily gastrointestinal), 25.4%

(93.6% of those affected continued treatment through minor dose adjustments)

Concurrent conventional therapies

Chemotherapy, 27.9%
Radiation therapy, 21.3%
Surgery, 19.7%

Adjunctive interventions such as supplement use, 49.2%
Dietary modification, 37.7%

Conclusions: In this prospective real-world cohort, the combination of ivermectin and mebendazole was associated with high rates of self-reported clinical benefit, with nearly half of participants reporting tumours regression or no current evidence of disease across a heterogeneous population of cancer patients.

These findings provide a compelling clinical signal that these well-tolerated, repurposed agents may offer therapeutic benefit.

However, observational design, reliance on self-reported outcomes, and potential for selection bias and uncontrolled confounding, these findings should be interpreted as hypothesis-generating.

Urgent prospective, randomized, placebo-controlled clinical trials

Validate these observations and further define optimal dosing strategies.

Mechanism (pharmacodynamics)

Ivermectin and mebendazole are antiparasitic agents,

demonstrated highly promising anti-cancer activity.

Ivermectin

Shown to exert over 14 distinct anti-cancer mechanisms across more than 12 cancer types,

inhibiting cancer cell proliferation, metastasis, angiogenesis, mitochondrial function.

Has demonstrated excellent safety in cancer patients (including those actively undergoing chemotherapy)

Ivermectin and mebendazole selectively target cancer stem cells

Mebendazole

Microtubule disruption, leading to effective cell cycle arrest

Potent induction of apoptosis

Significant inhibition of tumour growth

Inhibition of angiogenesis

Disruption of glucose uptake

When used together

Target non-overlapping pathways, resulting in synergistic tumour regression,

cancer stem cell depletion, and reversal of multidrug resistance in multiple in vitro and in vivo models

Biodistribution, ivermectin and mebendazole document excellent tissue penetration

[Kenny Carmody @KennyCarmody]

The Silence Is the Answer

COVID changed something in me that cannot be unchanged.

Not the virus. Not even the mandates. What changed it permanently was watching every government on earth arrive at the same silence, at the same moment, and hold it for six years running.

I want to be precise about what I mean, because precision matters here more than almost anywhere. I am not describing the ordinary silence of institutions managing complexity. I am not describing the understandable lag between events and accountability that all large systems produce. I am describing a universal, coordinated, sustained refusal to acknowledge a specific category of harm to a specific group of people, maintained across every major government on earth, across every regulatory agency, across every mainstream media environment, for six consecutive years.

Nearly six years since the rollout began. Not one head of state has stood before their people and said: some of you were harmed, we know it, and you deserve an honest accounting. Not one parliamentary inquiry with genuine authority and genuine independence. Not one compensation framework built on the actual scale of injury. The vaccine injured remain without diagnostic codes in most countries. Without legal recourse in jurisdictions that specifically restructured liability law to prevent it. Without the most basic institutional acknowledgment that what happened to their bodies was real.

This is what accountable institutions do after genuine public health emergencies. They review. They audit. They ask who was harmed and how. They produce findings that are uncomfortable because the discomfort is the point. The discomfort is how trust gets rebuilt. Post-event review is not a courtesy extended to the public by benevolent institutions. It is the mechanism by which democratic societies maintain the relationship between the governed and the people who make decisions affecting their lives and bodies.

We do not have that. What we have is a wall.

A Thread🧵