Antonia Drinnenberg

HFSP fellow in Deisseroth lab @Stanford. Vision, circuits, cell types. All-optical experiments in cortex.

[Antonia Drinnenberg @ADrinnenberg]

What if we could watch AND control thousands of individual neurons in behaving mice—with stable access over months? 🧠⚡ Our new preprint introduces transgenic all-optical tools that make this possible - and a resulting surprising discovery! 🔭💡
https://t.co/IvHWooqUmu 1/13 🧵

[Surya Ganguli @SuryaGanguli]

Our new paper on large scale holographic read-write experiments observing and controlling thousands of neurons in mouse visual cortex reveals a new functional cell-type that detects even moderate levels of excess activity (just 50 extra neurons firing) then inhibits top down cortical inputs.

This cell type is a subclass of somatostatin neurons, whose dysfunction is implicated in schizophrenia.

This suggests an intriguing hypothesis for the origins hallucinations in schizophrenia: the breakdown of this highly sensitive cortical gate allows top down inputs to enter visual cortex that should not, creating hallucinations.

This work was expertly lead by @ADrinnenberg w/ @allanraventos and @Alex_Attinger on data analysis and theory. Another fun collab w/ @KarlDeisseroth!

For more see: https://t.co/bBNPiFd8C0

And also this excellent thread: https://t.co/s31JiPW1Fm

[Antonia Drinnenberg @ADrinnenberg]

We'll be at #SfN2025 ✨!

🗓️📍Come visit our late-breaking abstract poster on Sunday morning: LBP020.05/LBP041

13/13

[Antonia Drinnenberg @ADrinnenberg]

What if we could watch AND control thousands of individual neurons in behaving mice—with stable access over months? 🧠⚡ Our new preprint introduces transgenic all-optical tools that make this possible - and a resulting surprising discovery! 🔭💡
https://t.co/IvHWooqUmu 1/13 🧵

[Antonia Drinnenberg @ADrinnenberg]

Amazing collaboration with @AllenInstitute team—@HongkuiZeng, @BosiljkaTasic, Tanya L. Daigle, La'Akea Siverts—to develop new transgenics for all-optical neuroscience.

And deeply grateful to @KarlDeisseroth for his support and mentorship. 🙏

12/13

[Antonia Drinnenberg @ADrinnenberg]

@PegahKF @unibern @snsf_ch Congrats!!

[Emilie Mace @EmilieMaceLab]

✨New preprint✨ Ever dreamed of combining brain-wide fUS imaging, two-photon imaging, ephys, and optogenetics in mice during your favorite head-fixed task? Want to also capture their facial expressions? We present the COMBO window to facilitate all these techniques!

[Ritchie Chen @ritchie_chen]

We’re excited to extend noninvasive optogenetics beyond the brain to address a nearly 150-year-old question in a new study out today @Nature:
https://t.co/DjQ22EAtWy
Work led by @HsuehBrian, myself, and @KarlDeisseroth, with an amazing team in the D-lab and many others!

[Antonia Drinnenberg @ADrinnenberg]

@kfrankelab @AToliasLab @uni_tue @bcm_neurosci Congratulations!!

[Antonia Drinnenberg @ADrinnenberg]

@liza_p_semenova @SchmidtFutures Congratulations Liza!!

[Antonia Drinnenberg @ADrinnenberg]

Thank you @SLBconference! I really enjoyed participating and am looking forward to the next SLB meeting already.

[SLB @SLBconference]

Congrats Antonia Drinnenberg on receiving a best poster presentation award (2nd place) !