It’s about time we remove CNS ppx in DLBCL from the NCCN guidelines.
High-Dose Methotrexate as CNS Prophylaxis in Ultra High-Risk Large B-Cell Lymphoma: An International Multicenter Analysis | Journal of Clinical Oncology https://t.co/cWhKcpvIzh
The vlogcast features Dr Patrick Harrington, Consultant Haematologist, Guy’s & St Thomas’ Hospital, discussing the new study on thrombosis risk in MPN patients using QRISK3 Score. Dr Harrington explains the research the team at Guy’s Hospital have done to see if a new way of assessing patients’ risk of thrombosis (clotting) called QRISK3, could be a useful tool for patients and their clinicians to judge their risk of having a clot. The research shows that QRISK3 is an accurate way of assessing risk and is likely to lead to it being used by MPN clinicians from now on.
The Study:
Used the QRISK3 score, a tool developed to estimate a person’s 10-year risk of heart attack or stroke, factoring in age, ethnicity, location, and various health metrics
Analyzed data from >1000 ET and PV patients treated at Guy’s & St Thomas’ Hospital
Patients had a median 8-year follow-up.
Practical Implications for Patients:
Patients can calculate their QRISK3 score online https://t.co/nt6iM8TUgp
If the score is elevated, it’s worth discussing modifying risk factors (like BMI, cholesterol, blood pressure) with a GP
Patients with high scores but no current cytoreductive therapy should talk to their haematologist, especially those around “borderline” age (50s–60s)
Next Steps:
The team hopes to expand the study across more centres and internationally to validate findings beyond a single hospital
You can watch the vlogcast, read the study and calculate your risk via the link here - https://t.co/vCct6WvSYs
@sarahbPhD@MPNVoice The QRISK3 model was developed in 2018, before the COVID-19 pandemic. Possibly in the next future, new models will be validated to consider it
Check out our paper looking at QRISK3 score as a predictor of thrombotic risk in MPN patients . Great collaborative work led by Patrick Harrington and Andrea Duminuco @ADuminuco#mpn
https://t.co/H9ps0VGdjW
Proud to share our recent study published on Leukaemia.
QRISK3 score can identify MPN patients with higher risk of TE based on CV risk factors that may benefit of early cytoreduction
https://t.co/AEwSikSEcz
@drpharrington@harrisoncn1