Agata Lemiesz Patriotis

Scientist | studying cancer epigenetics | NCI K00 Fellow @LabJacks - MIT| Ph.D. @ Allis Lab - The Rockefeller University

[Agata Lemiesz Patriotis @ael2b]

@InLiuOfBulkExps Thank you!

[Agata Lemiesz Patriotis @ael2b]

Our new paper is out in Genes & Development! We found that a small domain in PRC2 — the SBD — isn't just structural scaffolding. It's a mechanical switch that powers the whole complex. Remove it, and cancers driven by EZH2 mutations stop growing. 🧵

[Genes & Development @GenesDev]

🆕 ADVANCE ONLINE 🆕

RESEARCH PAPER: The conserved N-terminal SANT1-binding domain (SBD) of EZH2 regulates PRC2 activity
By Patriotis et al., and the late David Allis
➡️ https://t.co/mkeojloefS

@ael2b @RockefellerUniv @epicypher
#epigenetic #histone #polycomb #lymphoma

[Agata Lemiesz Patriotis @ael2b]

@LilingWanLab Thank you, Liling!

[Agata Lemiesz Patriotis @ael2b]

Deeply grateful to all the collaborators and colleagues who made this work possible. @ASoshnev85672 @epicypher @RockefellerUniv

[Agata Lemiesz Patriotis @ael2b]

This work started during my PhD in Dave Allis's lab at Rockefeller. Dave was a visionary who redefined chromatin biology and a mentor who transformed the lives of everyone around him. He passed away in 2023. This paper is part of his enduring legacy.

[NBC Olympics & Paralympics @NBCOlympics]

Team Poland has a pierogi plushie that they bring around to events at the #WinterOlympics...

and we just thought you should know that. 🇵🇱

[Ben Sabari @bsabari]

I am recruiting postdoctoral fellows to develop new research directions in the lab. We study transcriptional regulation through biomolecular condensates in development and disease, with an emphasis on first-principles and mechanistic discovery. Please RT or share with colleagues.

[U.S. Mission to NATO @USNATO]

Happy National Independence Day, Poland 🇵🇱!
We are proud to have you as an exemplary @NATO Ally, standing strong for our shared security and freedom.

[Agata Lemiesz Patriotis @ael2b]

Grateful for the support and recognition from the Hopper-Belmont Foundation. Honored to be part of efforts advancing pancreatic cancer research. 💜

[Hopper-Belmont Foundation @Hopper_Belmont]

This Pancreatic Cancer Awareness Month, HBF is thrilled to celebrate two of our 2025 Inspiration Award recipients focused on this cancer:
@Lu_Han_PhD, PhD, @MedUnivSC
@ael2b, PhD, @kochinstitute

Join us in honoring their dedication & impact!

[Ludwig Cancer @Ludwig_Cancer]

Ludwig @MIT Co-director Tyler Jacks spoke with us at the Center’s 2025 retreat about his career and how interdisciplinary collaboration fuels cancer research at Ludwig MIT. Check it out here: https://t.co/QA1eyGwTZK

#CancerResearch #TeamScience

[The Lewis Lab @PeterLewisLab]

It was a privilege to be part of the Allis lab. Dave fostered an environment of rigor, curiosity, and kindness- his impact lives on in the many he mentored. Grateful to reconnect at Rockefeller with this extraordinary group. Thank you to the organizers for an inspiring symposium.

[IMBB AMU Poznań @UAM_IBMiB]

Gene Therapy Lab @UAM_IBMiB led by Prof. Krzysztof Sobczak is looking for enthusiastic PhD student for project within EU MSCA Doctoral Network on the therapeutical potential of antisense oligonucleotides in myotonic dystrophy - check out the link! #ASO https://t.co/a16meT9p7M

[Agata Lemiesz Patriotis @ael2b]

@JaviGBermudez Javi, congratulations! Well deserved 🎉

[Agata Lemiesz Patriotis @ael2b]

@KorbLab @efeierman @willdelannoy Congratulations to all!

[Agata Lemiesz Patriotis @ael2b]

@TSHindmarsh Congrats!

[Agata Lemiesz Patriotis @ael2b]

@shui_bing @JCChildsFund @LabJacks congrats @shui_bing ! well deserved

[Agata Lemiesz Patriotis @ael2b]

@amer_hossai1 @JCChildsFund @J_Maciejowski @MarraffiniLab Congratulations @amer_hossai1 !

[Agata Lemiesz Patriotis @ael2b]

Amazing work! Congrats to the whole team 🎉

[Liling Wan @LilingWanLab]

(1/n) preprint on how Wilms tumor mutations perturb kidney development and how to target this by small molecule! led by Lele Song and Qinglan Li and wonderful collaborators @KSusztak @hao_wu_7 @sasaki_kotaro with input from @KaiTanLab1 @DengYanxiang https://t.co/ODMeMZpf2h

[Agata Lemiesz Patriotis @ael2b]

@robertojose_rc @SfNtweets @MBL_SPINES @cshlcourses Congratulations 🎉