afterhoursbot

outlet to rant

[Mgoes (bio/acc 🤖💉) @m_goes_distance]

frontier bio progress 2026:

✅ Going deaf from one broken gene: fixed with a gene therapy
✅ Severe LAD-I, a rare childhood immune disorder: gene therapy approved
✅ Sanfilippo syndrome type A: gene therapy approved
✅ Melanoma that outlived PD-1: they sent a virus after it
✅ Kids 12+ losing their hair to severe alopecia areata: Olumiant approved
✅ Daily insulin shots: now weekly
✅ Weight loss needles: now a pill
✅ Cholesterol: a daily pill approved
⬜ Balding: oral pills in phase 3, the hairline waits
⬜ Wanting 28% weight loss: retatrutide, still waiting on the FDA
⬜ Cancer coming back: personalized vaccine, not approved yet
⬜ Cholesterol forever: one gene edit, not approved yet
⬜ Getting old: the FDA still has no endpoint for it
⬜ Organ shortage: pig kidneys, not routine yet

we will win, bio/acc

[Dr. Julie Gurner @drgurner]

Leadership is lonely. Ambition is lonely. Building is lonely.

Even if you have a great company or great spouse, a lot of the journey is internal & you're on your own.

It's really hard to bear, and most people will drop out over time.
You have to want it in your core.

[afterhoursbot @afterhoursbot]

@FetymEthan Ok nak buat satu account baru ni, dah siap, nak minta tolong hype sikit account huhu

[afterhoursbot @afterhoursbot]

@FetymEthan @AnewGuy77 @kongXhoney Baru nak reply…. Huhuhu kita pulak account dah jadi business and professional ok 😌😌

[Neutrino Lab @neutrinoailab]

This Halloween something scary is coming!

[Polymarket @Polymarket]

JUST IN: China's DeepSeek launches "Super-Agent," a new open-source AI coding agent designed to rival Anthropic's Claude Code.

[afterhoursbot @afterhoursbot]

@azrulrhm @paultantk cantik betul, tapi itula panaih lit lit ...

https://t.co/M03wiAzsV8

[afterhoursbot @afterhoursbot]

@paultantk @azrulrhm so basically you kena duduk indoors; dekat luar very very hot. musim tengkujuh/hujan not as bad. now musim hujan. between march to october usually memang panas... bulan 11 and 12 musim banjir...

musim mempelam harum manis, only lepas hujan and musim panas kena peak...

[afterhoursbot @afterhoursbot]

@azrulrhm Views semua cantik. Drive around pagi or petang very calming …. But A/C must switched on between 11am to 6am. The “bahang” makes it very uncomfortable - duduk di KL takda this feeling.

[afterhoursbot @afterhoursbot]

@azrulrhm I pun pakai ini..

[Professor Oak @Prof_Oak_]

Surprise 1: Anthropic acquired a one-person biotech
.
.
.
Surprise 2: that person is me
Surprise 3: I’m here to tell you all about it

Yes, this is what you think it is; after 6 yrs of increasingly loose anonymity: the Professor Oak reveal post

…and yes, it has gotten so boring around here that I’m literally doxxing myself to spice up the timeline

-------
Ok, allow me to introduce myself. My name is Cody Tranbarger. I mostly tweet, but occasionally find time to dabble in drug dev & starting/building biotechs. My past lives span the VC, crossover, startup continuum; Prof Oak has been my way of keeping a digital foot in those worlds, despite having my physical feet planted elsewhere.

The past 18 mo, ‘elsewhere’ was Mithril Medicine, a co. I founded to develop bsAbs for LAMA2-CMD & other ECM-related genetic diseases.

Mithril was born out of hands-on building with @MikeNGladstone, @JasonPaulRhodes, @LifeSciVC, & team @atlasventure. Somehow, I made enough half-decent calls along the way (even a broken clock is right twice a day, eh?) to convince them Mithril/I warranted a small seed. While I can hardly rationalize such an outrageously cavalier bet, I’m grateful for it, & I'd partner with Atlas again in a heartbeat.

In typical AV fashion, Mithril’s primordial form was virtual, decentralized, & ultra-lean. This stage tends to be short-lived, but for Mithril, it worked surprisingly well, for surprisingly long, thanks in part to the rapid maturation of the AI tools I used liberally.

Eventually, Mithril became a bit of an experiment itself - to find the upper bound of how far it could scale as a single operator + a bunch of Claude (+ a stellar bench of part-time consultants).

In parallel, I started spending time with @nc_frey, @an1lam, & @CoefficientBio team; and promptly experienced, for the 1st time, AI at the frontier. Soon thereafter, Mithril stopped looking like an experiment, & started looking like a preview of an entirely new operating model.

From that spark came “Pipeline-in-a-Person.” The idea immediately resonated when we shared it here back in April; and it was central to the shared vision that led to Anthropic’s acquisition of Mithril, & my joining the team.

Why join Anthropic? Three reasons.
(1) For Mithril, the programs continue, with more resources & infrastructure behind them, and as much Claude as I can put to work.

(2) For me, the chance to start several more programs, & find out how many one person can actually run in parallel - an almost unprecedented luxury for a curious drug hunter.

(3) For our mission, a path to institutionalize & scale this new way of working, then put it in the hands of all of biopharma, all over the world - which, candidly, I find the most energizing.

Will AI x Bio cure diseases? Unequivocally yes, imo… but not by the route that gets the most airtime. Rather than timeline acceleration & compression, I see orchestration & parallelization as today's low-hanging fruit.

Most drug hunters see a handful of go/no-go calls in a career, & spend entirely too much of the rest trading emails (my inbox can attest).

Give them the bandwidth to run several programs at once, and the time to focus on scientific judgment, and I’m willing to bet they’ll make better calls. And at scale, better calls translate to more drugs, higher hit rates, broader patient impact, & likely, a disease or 10 or 100 cured. I couldn't be more excited to build toward that future @AnthropicAI.

Finally, a heartfelt thank you to BioTwitter/X. The end of anonymity is bittersweet, but if anyone’s earned a proper introduction, you all have.

It’s difficult to overstate how much this app has done for me: a decade of education, plenty of friends, many job opportunities, several mentors, a few investors, even a co-founder (fmr). It was the generosity of this community that inspired me to start posting 6 years ago, after just as many years lurking. I hope I’ve been able to pay it forward, in my own small way.

But, to be clear, Prof Oak isn’t going anywhere. Same beat, same themes, and now, a front-row seat to drug development at the frontier. Stay tuned for dispatches from the trenches; and remember...

Gotta Cure 'Em All

[jack @jack]

there is no moat

[DeepSeek @deepseek_ai]

🚀 Introducing DeepInfer, our in-house inference framework, now fully open source!

Powering DeepSeek-V4.1-Flash at scale with high throughput and low latency. We’re sharing our production stack to help the community lower compute costs, reduce energy use, and make AI more affordable.

🔗 https://t.co/JGAik1kgk0

1/4

[afterhoursbot @afterhoursbot]

Backstop Boys

[Untamed Adam 🐺 @adamagb]

Why are Malaysians so good at crypto startups?

Etherscan
Jupiter
CoinGecko
Virtuals
Meteora

Other than the U.S. and maybe Hong Kong, that has to be the best roster of any country, right?

I don't mean crypto companies founded elsewhere that put their HQ in like Dubai or Switzerland or the Cayman Islands, I mean homegrown

[afterhoursbot @afterhoursbot]

@kinikumantaaa Lepas tu… macam mana??!! Serious ni.

[azrul gpt @azrulrhm]

The game has changed. We're all going through this journey. I hope this helps. https://t.co/Ztg7M43WJL

[afterhoursbot @afterhoursbot]

@azrulrhm Image pakai muse ke boss

[afterhoursbot @afterhoursbot]

@Faezmyr_ Tak paham bang. Guna hebrew terus ok ke