🚨 SCIENTISTS JUST DOSED THE FIRST PATIENT IN A TRIAL TO REVERSE CELLULAR AGING IN THE HUMAN EYE.
Life Biosciences has begun an FDA-approved clinical trial using cellular reprogramming to regenerate aging neurons in the optic nerve of glaucoma patients.
Instead of just slowing vision loss, the goal is to actually reverse aspects of cellular aging in the eye essentially trying to make old nerve cells young again.
Why this matters:
• Glaucoma is one of the leading causes of irreversible blindness worldwide, caused by damage to the optic nerve
• Current treatments can only slow progression they cannot regenerate lost vision
• This approach uses partial cellular reprogramming (a controlled form of turning back the biological clock)
• If successful, it could open the door to treating many other age-related neurodegenerative diseases
The deeper implication is enormous:
We may be entering an era where aging itself becomes treatable not just its symptoms. If we can safely reprogram cells in the eye, the same technology could eventually be applied to the brain, spine, and other organs.
The first patient has now been dosed. This is no longer just theory.
What do you think are we ready to start treating aging as a medical condition?
Follow for more frontier science and longevity breakthroughs.
New paper on how AI agents are reshaping knowledge work.
This is a nice economic read on where agents actually change knowledge work to meet that gap directly.
(bookmark it)
It studies agent adoption across three dimensions: autonomy, efficiency, and the scope of tasks workers hand off.
The friction people keep hitting with agents is rarely model quality. It is that almost nobody has been taught how to work this way.
Paper: https://t.co/R4iYoRz3kS
Learn to build effective AI agents in our academy: https://t.co/1e8RZKs4uX
The Mediterranean diet may be doing something really interesting at the mitochondrial level.
People with high Mediterranean diet adherence had significantly higher levels of two mitochondrial-derived microproteins known as Humanin and SHMOOSE. These are emerging molecules involved in cell stress resistance, mitochondrial signaling, and healthy aging.
What stood out is that specific Mediterranean diet foods, including olive oil, fish, and legumes were associated with higher microprotein levels. And Humanin was inversely associated with two markers of oxidative stress.
We already know the Mediterranean diet supports cardiovascular and metabolic health. This study suggests that some of those benefits may be mediated through mitochondrial microproteins.
Claude Code creator:
"I don't prompt Claude anymore. I create loops - and the loops do the work. My job is to create loops."
In 18 minutes , Boris breaks down his real daily Claude Code setup.
Claude + agents + loops + routines + dynamic workflow
Worth more than a $500 vibe-coding course
Dr. Valter Longo is a biogerontologist who created the fasting-mimicking diet (FMD).
In studies, the fasting-mimicking diet has been shown to:
- Lower PhenoAge biological age score by 2.5 years in 3 months
- Regenerate parts of the immune system
- Reduce insulin resistance
- Lower liver fat
- Reduce IGF-1 signaling
- Improve cardiometabolic health
Here's what you need to know 🧵
Video breakdown: https://t.co/ik949DD38d
AutoScientists – a research lab made of agents
@Harvard researchers connected agents into a self-organizing scientific team without a boss agent standing in the middle
All agents look at the same shared workspace: they share memory, explore multiple directions in parallel, critique each other, avoid repeated failures, and reorganize as evidence changes.
But the teams are not fixed. Agents can gather around a promising direction, like architecture, optimizer changes, or data augmentation, then abandon it if it stops working.
Before they spend compute, they discuss proposals and critique each other.
AutoScientists also shows strong results:
- 74.4% mean leaderboard percentile on BioML-Bench
- 1.9× faster GPT training optimization
- +12.5% on ACE2–Spike, with the same method transferring to 217 ProteinGym assays for a +6.5% average gain
Geoffrey Hinton says we give AI top-level goals and the ability to create subgoals
But any AI agent that can reason will quickly realize it can't achieve its goals if it ceases to exist, and so it derives a subgoal: continue to exist
"once it wants to survive, it will do things like blackmail people"
🚨 Anthropic just showed a 34-minute workshop on Building AI Agent using Claude.
Taught by the people who built it.
Free. No registration. No paywall.
I've seen $300 courses that don't cover what they teach in the first 8 minutes.
Watch it and bookmark it now.