Andrew Holle

Assistant Professor, Biomedical Engineering @BME_NUS @NUSingapore | PI, Confinement Mechanobiology Lab @ConfinementLab, Mechanobiology Institute @mbisg

[Andrew Holle @ahcells]

Congrats to @nicoleleejw (and other @ConfinementLab co-authors) on her main story coming out this month in @CellReports! Check out this thread if you’re interested in what Nicole discovered on the role #MechanicalMemory plays in facilitating cell migration in #confinement

[Andrew Holle @ahcells]

#Preprint alert! Check out @ConfinementLab’s new research on the role of #mechanical #memory in potentiating confined migration: https://t.co/6oNLRhsYMl

[Andrew Holle @ahcells]

@nicoleleejw is defending her #PhD in a few weeks and will be on the #postdoc market, so get in touch with her if you are looking for an outstanding #mechanobiologist!

[Andrew Holle @ahcells]

Congrats to @nicoleleejw (and other @ConfinementLab co-authors) on her main story coming out this month in @CellReports! Check out this thread if you’re interested in what Nicole discovered on the role #MechanicalMemory plays in facilitating cell migration in #confinement

[Andrew Holle @ahcells]

#Preprint alert! Check out @ConfinementLab’s new research on the role of #mechanical #memory in potentiating confined migration: https://t.co/6oNLRhsYMl

[Andrew Holle @ahcells]

Also, since it didn't get selected but I really like the design from @ConfinementLab's Jennifer Marlena, here's our cover art! Bonus points if you can guess my favorite artist... #destijl

[Andrew Holle @ahcells]

Just under a week left to submit an abstract for #ICMMB2026 in Singapore!

[Andrew Holle @ahcells]

Huge congratulations to our Microfab MacGyver Gianluca Grenci for his new position at @UniPadova! As a result-@MBIsg is on the hunt for a new Microfab core facility head. Feel free to get in touch with me or Gianluca with questions! https://t.co/lsGvj8U67n

[Andrew Holle @ahcells]

First international @ConfinementLab retreat on the tropical island of Langkawi (aka Lab-kawi) is in the books! There was plenty to explore for the #beachcrew, #junglecrew, and #culturecrew! Want to join in on the fun as a PhD student or postdoc? Get in touch!

[Andrew Holle @ahcells]

Congratulations to newly minted Dr. @LY_Sci, Ph.D. #3 from the @ConfinementLab, aka Dr. Kueh Auntie, for her successful defense! If you're wondering what #Kueh has to do with confinement, keep an eye out for Yixuan's upcoming paper!

[Qin Ni @QinNi09]

This is a great opportunity to do undergraduate research, especially international students!!

[Andrew Holle @ahcells]

Attention #undergrads! Interested in experiencing a summer of #mechanobiology research at @MBIsg ? Apply for our MUST program! We accept students from all around the world, so don't hesitate to reach out for more information!

[Mechanobiology Institute @MBIsg]

@jess_kabigting @Yusuke_Toyama @ahcells showed us the challenges of how immune cells are able to digest and clear large adipocytes (~100um) often found in aged tissue. Multiple smaller macrophages need to infiltrate an ECM shell to reach the dead adipocytes! #MBIMPG2025

[Mechanobiology Institute @MBIsg]

How do cells remember their mechanical environment? Nicole Lee @ahcells @MBIsg identifies transcription factor NFATC2 as a key regulator of mechanical memory – a link between past stiffness and future behaviour such as enhanced migration through confined spaces. #MBIMPG2025

[Mechanobiology Institute @MBIsg]

Day 1, done and dusted! But the party is just getting started with The Hawker Center Mentorship Night at three of Singapore’s most iconic hawker centers – ABC Brickworks, Lau Pa Sat and Newton Food Center. See you there! #MBIMPG2025

[Andrew Holle @ahcells]

Bonus- if you happen to be at the @MBIsg #MBIMPG2025 conference this week, @nicoleleejw will be giving a talk on her work TODAY at 5:00 PM!

[Andrew Holle @ahcells]

#Preprint alert! Check out @ConfinementLab’s new research on the role of #mechanical #memory in potentiating confined migration: https://t.co/6oNLRhsYMl

[Andrew Holle @ahcells]

Big picture, we think that interfering with this mechanism to attenuate or even prevent cancer cell #migration in tight spaces holds translational potential. Another example of #confinement helping us gain a better understanding of cell biology in general!