Confinement Mechanobiology Lab at MBI

We are the Confinement Mechanobiology Lab at @NUSingapore and @MBIsg. PI @ahcells, tweets by a rotating cast of group members

[nicole lee @nicoleleejw]

🚨 New preprint alert! 🚨
Our paper “Mechanical Memory Primes Cells for Confined Migration” is now live on @biorxivpreprint
👉https://t.co/GUqEc7NLoI
We uncover how cells "remember" past stiffness environments and use this memory to navigate #confinement. #mechanobiology

[Confinement Mechanobiology Lab at MBI @ConfinementLab]

Join us at @MBIsg!

[Andrew Holle @ahcells]

Interested in a #postdoc on nuclear #mechanobiology? We have a fully funded position in the @ConfinementLab designed to help you meet your career goals while researching the rapidly growing field of cellular #confinement. Please get in touch for more info!

[Andrew Holle @ahcells]

Just a few days to submit for the Sep 9-12 @MBIsg conference! Cool feature this year- a #HawkerCentre night with speakers and ECRs. Imagine enjoying Char Kway Teow & chatting #microtubules with someone like Sasha Bershadsky! Register here: https://t.co/VDllpECQqH

[Confinement Mechanobiology Lab at MBI @ConfinementLab]

Very cool finding🧩: It doesn’t matter if a cancer cell is more or less deformable, it still makes similar choices when navigating #confinement. @gijsjekoenderi1 team shows that “squeezability” alone doesn’t explain how cells pick their path!

[Confinement Mechanobiology Lab at MBI @ConfinementLab]

How do cells 'feel' confinement? New research reveals how mechanical confinement compresses the #nucleus, triggering immobile cells to spread and migrate. -YJ https://t.co/sT7MoctPlD

[Confinement Mechanobiology Lab at MBI @ConfinementLab]

Surprise! 🤯Acute #chromatin decompaction stiffens nuclei (not softens!) via swelling & #lamin changes. Nanopillars reveal this time-dependent effect. Metastatic cells dodge stiffening by compacting chromatin—key for #confinedmigration. -NL https://t.co/Bt4vgPYq53

[Confinement Mechanobiology Lab at MBI @ConfinementLab]

Fascinating in vivo tracking of collective cell migration under confinement @PNASNews! Reveals self-organized antiparallel streams and compressive ECM deformation. Now wondering: How do single cells navigate these complex microenvironments? 🤔 -LY
https://t.co/YtHqxHWpcP

[Confinement Mechanobiology Lab at MBI @ConfinementLab]

Tumbling=better #StemCell differentiation? A @NatureMaterials study by @AyushmanManish et al showed ‘cell tumbling’ under #confinement in sliding hydrogels enhances cartilage formation by impacting nuclear #mechanotransduction & chromatin accessibility-SS https://t.co/WkVGpRw9Bd

[Confinement Mechanobiology Lab at MBI @ConfinementLab]

It's always fascinating to observe cell migration in #confinement in vivo! This study from @SZapperi and @CAMLaPorta et al used intravital multiphoton microscopy to uncover a multicellular, low-cohesion mode of HT1080 collective migration-GX https://t.co/TOf9tTdZzA

[Confinement Mechanobiology Lab at MBI @ConfinementLab]

An exciting study from the @KKLabJHU lab reveals that extracellular fluid viscosity alone can drive adipogenic-to-osteogenic stem cell transition, even under adipogenic-favoured conditions. A promising step for the future of #StemCellTherapy ! -YJ
https://t.co/ounGeJZiBg

[Confinement Mechanobiology Lab at MBI @ConfinementLab]

Check out our latest review! We dive into the physical environment of primordial germ cells and explore the role of #confinement and mechanics in guiding their journey to a #germline fate. Stay tuned for more on germ cell #mechanobiology!
https://t.co/xofIdQwR7U

[Confinement Mechanobiology Lab at MBI @ConfinementLab]

Excellent study by the @Marta_Shahbazi lab! Physical separation of epiblast cells from the basement membrane enables germ cell specification by releasing an integrin-mediated block. Great example of physical cues guiding #pluripotent cell fate! -MC
https://t.co/0LpIMptMem

[Confinement Mechanobiology Lab at MBI @ConfinementLab]

All good things must come to an end! Signing off on the last day of WBC2024. Cheers to all the amazing scientific talks and beautiful connections. Thank you everyone for making this a great experience.
Special thanks to @YuSukChoi, @nano_jenn, Hwang lab, @shin_shinpark
- RH,MK,SS

[Confinement Mechanobiology Lab at MBI @ConfinementLab]

Congratulations to Yeji from @ConfinementLab for the best poster award at the @2024Wbc. She is exploring the activation of fibroblasts as a function of confined migration.
You go girl !! - RH & MK
#Biomaterials #WBC2024

[Confinement Mechanobiology Lab at MBI @ConfinementLab]

Awesome talk by @SamuelJMaher from the Cell Mechanobiology Choi Lab @YuSukChoi on using the gradient hydrogel system to understand the role of volume adaptation in regulating stem cell function. - RM & MK
@2024Wbc #Biomaterial #mechanobiology

[Confinement Mechanobiology Lab at MBI @ConfinementLab]

Amazing work by Prof Kristopher Kilian @KrisKilian @UNSW on cancer shapeoids using hydrogel microstructures of varying stiffness and geometry @2024Wbc - MK & RH

#biomaterials #WBC2024

[Confinement Mechanobiology Lab at MBI @ConfinementLab]

Learning about the importance of scaffold design and long-term testing of heart valvular implants. Really inspired by the keynote speaker Dr. Carlijn Bouten @TUeindhoven. @2024Wbc - RH & MK

#WBC2024 #biomaterials

[Confinement Mechanobiology Lab at MBI @ConfinementLab]

Great keynote from @khademh at @TerasakiInst discussing the different applications of GelMA in tissue engineering and regenerative medicine at @2024Wbc. -MK & RH

#biomaterials #WBC2024

[Confinement Mechanobiology Lab at MBI @ConfinementLab]

True Regeneration is when we control inflammatory responses. Great talk by Prof.Milica @milicaruoft on using citric acid based polymers as 3D tissue velcros for reduction in invasiveness of surgeries. - RM & MK
@2024Wbc #biomaterial

[Confinement Mechanobiology Lab at MBI @ConfinementLab]

Welcome to the final day of @2024Wbc. The "Young"-sters @ranmadusha @MartinKiwanuka from the soft nano-biomaterials lab @nano_jenn at @MBIsg are taking over the @ConfinementLab channel. Stay tuned! -RH & MK

#biomaterials #WBC2024