Aizan

Stack-tracing down to silicon gates, 4.6 billion cycles within a second.

[Jason Sheltzer @JSheltzer]

The stock price for $SNOA (Sonoma Pharmaceuticals) shot up 10% after the Nobel Prize announcement this morning - but it's the wrong company. Fred Ramsdell works for Sonoma Biotherapeutics, which is not publicly listed!

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

[Aizan @aixnr]

@TYewdell That first paragraph in the discussion section is something I would assume taken from sci-fi novels....

[Aizan @aixnr]

@mardhea_oi why not both?

[Aizan @aixnr]

@PRobertImmodels Happy to connect to chat about flu HA as model for evolution under mAb pressure

[Aizan @aixnr]

@PRobertImmodels Flu A HA is probably a difficult first target, given the mutational flexibility.

So here's measles.

https://t.co/qwPxTwoWeA

[Aizan @aixnr]

@PRobertImmodels I assume the authors have looked into model viruses to play with. One group did attempt this experimentally with lab-strain flu A. The flu mutational space is constrained (1 mAb vs. 1 residue on flu HA) and they continued selecting for dozens of rounds

https://t.co/6nYgkep0BR

[Aizan @aixnr]

@strnr Initially I tested workflow orchestrators SnakeMake and Nextflow. Ended up writing a custom and specific 'orchestrator' in Go to keep the SIF size smaller.

[Aizan @aixnr]

@strnr I tested this idea putting tools into a Singularity container (Docker image 'converted' to SIF). It worked. This was to solve the pain of working with outdated packages on NIAID HPC.

https://t.co/qgnWu2p4U9

[Aizan @aixnr]

@emy9941 Nice, I see a lot of PIs I recognize on this paper. Congrats to them

[Kelsey Piper @KelseyTuoc]

"no one has died" because of feeding USAID to the woodchipper, Elon claimed. In this devastating piece the NYT went out and learned some of their names and stories:

[The Atlantic @TheAtlantic]

Doctoral programs are pausing or cutting back admissions. This is just the latest signal that the future of the university is under threat, @ibogost writes: https://t.co/60XYbtBZKb

[Dr. Angela Rasmussen @angie_rasmussen]

I have worked with many untenured staff scientists & PIs at NIH. They are incredible colleagues who chose science in public service over more lucrative careers. Devaluing their commitment & professionalism is among the most cruel aspects of the DOGE purge

https://t.co/ODnuM5vooY

[Aizan @aixnr]

https://t.co/BXMF6JMdwh

[Nature Portfolio @NaturePortfolio]

A study in @NatureMicrobiol demonstrates that phenotypic flexibility allows influenza A virus to rapidly respond to environmental pressures in a way that provides dynamic adaptation potential in changing surroundings. https://t.co/GSUCVkGVNb

[Dr Kareem Carr @kareem_carr]

i used to be a cancer researcher at one of the most well-funded institutes in america. our lavish spending was like sometimes we'd have an ice cream social.

[NIH @NIH]

News: Influenza A viruses adapt shape in response to environmental pressures https://t.co/uFPbbg39tQ

[Aizan @aixnr]

@zamirmohyedin tumpang tanya. sumber asal gambarajah ni di mana ya?

[so? @0flameprincess0]

🚨🚨🚨

Trump’s latest foreign aid policy is directly impacting a Malaysian wildlife NGO. Staff will not be getting salaries for three months at least as they are ordered NOT TO INCUR ANY EXPENSES.

📢 BLOW THIS UP 📢