David A. Alagpulinsa, PhD

Assistant Professor @Yale @YaleMed⏐Human Genetics⏐Hematopoiesis⏐Neuroimmunology⏐Type 1 diabetes⏐Cardiometabolic disease⏐Nature, Virtue & Freedom⏐

[David A. Alagpulinsa, PhD @Alagsdave]

We are delighted to share our new work as a preprint on medRxiv, examining hematopoietic aging in type 1 diabetes (T1D).
Analyzing data from >416,000 UK Biobank participants, we show that T1D is associated with accelerated hematopoietic aging, including earlier clonal hematopoiesis (CHIP) and disease-accelerated telomere attrition. Interestingly, telomere attrition—but not CHIP—was associated with myocardial infarction risk in T1D.
By integrating epidemiology, human genetics, Mendelian randomization, and single-cell regulatory genomics, our work identifies telomere biology as a potential contributor to excess cardiovascular risk in T1D.
This work was led by the incredibly talented Ziang Xu, who will join the University of Pennsylvania this summer for a PhD in Genomics & Computational Biology.
Congratulations as well to co-author Sourav Roy, who will also join the Duke University MD/PhD this summer.
We are very proud of them and excited to see them take this next step in their scientific journeys.

Accelerated hematopoietic aging in type 1 diabetes links telomere attrition to myocardial infarction https://t.co/iEOb9HkZFI

[The Lancet Diabetes & Endocrinology @TheLancetEndo]

A growing population of individuals with type 1 #diabetes living into older adulthood underscores the need for health systems to address the organisational, societal, and care challenges associated with #ageing with the condition https://t.co/7wq1T2jiKE
#T1D #olderadults #aging

[The Lancet Diabetes & Endocrinology @TheLancetEndo]

New—Type 1 #diabetes in older populations https://t.co/7wq1T2jiKE
#T1D #olderadults

[Yuri Pritykin @YuriPritykin]

Excited to share our new paper out in @NatureComms !

We introduce ArchVelo, a new computational framework for RNA velocity and trajectory inference from single-cell multi-omic (scATAC+RNA-seq) data:
https://t.co/YCjbHhhUQd

[nature @Nature]

Nature research paper: Genetic background sets the trajectory of experimental cancer evolution

https://t.co/1hS1z0ETbx

[IGVF @IGVFConsortium]

FastGxC enables fast, powerful mapping of context-specific eQTLs from bulk and single-cell RNA-seq data, improving trait interpretation while expanding candidate causal genes.

Explore the study: https://t.co/eJmqJ2Qh2R

[Nature Metabolism @NatMetabolism]

Distinct brain regions mediate regulation of food intake in response to GIPR agonism or antagonism https://t.co/GqlsGjHRDS

[NEJM Evidence @NEJMEvidence]

Review Article by Kristen E. Schratz, MD, and Mary Armanios, MD: Disorders of Telomere Length https://t.co/HboF3JdACX

#Genetics

[Eric Topol @EricTopol]

Super Ager cognitive status with exceptional late-life memory was not explained by APOE alleles or polygenic risk scores (PRS) for Alzheimer’s disease
https://t.co/wo2laQNewn

[htw @heniek_htw]

Exercise initiated in early life promotes cognitive resilience and prevents neurodegeneration
https://t.co/F3g26M7ekF

[The Lancet @TheLancet]

Irritable bowel syndrome (IBS) affects 5–10% of people worldwide.

In @LancetGastroHep, authors discuss the current understanding of the pathophysiology of IBS in terms of peripheral, central, and integrated mechanisms.

Read now: https://t.co/Y8YwCVdnhl

[EMBL Events @EMBLEvents]

Last chance to submit your abstract for 'DNA replication and genome maintenance: from basic biology to human health'!

If you work in DNA replication, genome maintenance, chromosome organisation, chromatin maintenance, or a related field, this meeting is for you – make sure to register before 28 July: https://t.co/upQT35w2Hs

🧬 Session topics
• Replisome structure and function
• Replication in time and space
• Chromatin replication and cell fate
• Replication stress and genome stability
• Replication-coupled DNA repair
• Replication in development, ageing, and cancer

📍 EMBL Heidelberg and Virtual
📅 20 – 23 October 2026
#EESReplication

[Luis J. Castro-Vega, MD, PhD. @LuisJaimeCastr3]

https://t.co/GLTQU0zqMZ

[The Lancet @TheLancet]

Obesity is increasingly addressed with disease-modifying medications, with benefits that extend across other conditions.

A Review in @TheLancetEndo explores the multisystem benefits of obesity medications beyond weight loss: https://t.co/elmnTFscDF

[David A. Alagpulinsa, PhD @Alagsdave]

@GeorgeAnagli @JDMahama very intelligent president. but the question is are you a president or a scientist?

[Waggoner Lab @LabWaggoner]

Review @NatureCellBio @AgingPitt
Lysosomes and lysosomal dysfunction in ageing biology
https://t.co/CFZ4H3d83y

[Nature Metabolism @NatMetabolism]

#Throwback

REVIEW | A Bonnefond, P Froguel et al

The genetics of obesity: aetiology, prevention and therapy

https://t.co/l6KvUER24k

[María A. Moro @MariAngelesMoro]

Neurovascular interactions in the ageing heart | Nature Reviews Cardiology https://t.co/EUDndAfPe8

[JAMA @JAMA_current]

Among cognitively unimpaired older adults, very high plasma #PTau217 levels were associated with a 38% risk of progression to #CognitiveImpairment within five years.

#AAIC26

https://t.co/Z8hvfQAknZ

[Nature Metabolism @NatMetabolism]

#Throwback

PERSPECTIVE | B Chen, M Schneeberger, E Topol et al

Obesity as a catalyst for neurodegeneration

https://t.co/tMWYlM6K6n

[The Lancet Diabetes & Endocrinology @TheLancetEndo]

In the August Issue:
Beyond weight loss: multisystem benefits of obesity medications https://t.co/IFPyEU8bKn
#obesity