//

・°☆•

[// @alemcnts]

ya tienen sus regalos de navidad??

llévate 7 perfumes de 10ml + 1 perfume de 30ml por solo $777

pide el tuyo por mensaje

[// @alemcnts]

@34thjesus i mean tiene sentido

[// @alemcnts]

increíble que este hombre enamorado va a encontrarle a la novia la cura de endometriosis, posiblemente PCOS tmb

viva el amor

[Bryan Johnson @bryan_johnson]

🚨Kate officially diagnosed with endometriosis

> done without surgery
> across three modalities: imaging, blood, and AI
> all non-invasive
> in 42 days

For context, average time to diagnosis is 6.6 years.

And, we found 2 other diagnoses at the same time.

Over the past 6 weeks, we’ve sprinted to confirm or deny Kate’s suspected endometriosis. Endo is notoriously challenging to diagnose.

It’s one of the most gnarly diseases and affects 15% of women.

Men, to get you on the same page, having endo is akin to an alien growing in your guts and balls, self replicating, and glueing everything together. Causing you constant pain and discomfort.

We got to work.

> got an MRI
> got a transvaginal ultrasound
> both results came back negative

At this point, Kate’s patient journey had followed the archetype precisely. Most women don’t get diagnosed for 7-10 years. For Kate, it’s been 7 years. And, like most women, her imaging came back clear even though now we know that she has endo.

This is why diagnosis has traditionally happened via surgery. There has been no other way than to open her up and look inside.

We wanted to avoid surgery so we went back to the drawing board. We searched the world over.

On our second go, we did:

> endo-specific ultrasound
> an endo blood test
> AI MRI
> saliva test

This was successful.

We were able to confirm her endo via ultrasound, blood test, and MRI. Confirmed simultaneously by three unique modalities, as far as we know, a world-first approach.

The extensive measurement allowed us to find additional things.

Her ultrasound showed:

> endometriosis
> PMOS (formerly PCOS) (needs confirmation)
> adenomyosis

30-40% of women have at least one of these conditions. That’s intimidating especially when the path to diagnosis is fraught with so many challenges.

Phase I was getting a diagnosis.

Phase II is curing endometriosis. We’ve already started working.

If you’re a female with suspected endo, here’s what you can do to accelerate your diagnosis.

—
1. Endo-Specific Ultrasound

You want an endo-specific ultrasound. As we saw with Kate, a standard pelvic/transvaginal ultrasound failed to identify her endo.

You want the ultrasound to be performed by a physician or sonographer specifically trained. They follow a special protocol to hunt for endometriosis by mapping the ovaries and uterus, and testing whether organs can slide freely, or are tethered by endometriosis lesions.

It’s best timed just after ovulation, when a small amount of peritoneal fluid aids visualization.

It can detect superficial endometriosis, lesions, and adenomyosis that general imaging misses.

We went to Dr. Kacey Hamilton at Cedar Sinai.

2. AI MRI / MatricesAI

Radiologists miss lesions in up to 60% of cases. We worked with @MatricesAI which leverages AI and a unique dataset to detect endometriosis lesions on pelvic MRI. This model is still new, its first pilot study with 200 participants began in April this year.

Here is how you can work with them:

They’re opening their diagnosis program at the Geneviève Institute to give early access to their AI model in a clinical trial.

They will take you through a state-of-the-art clinical intake questionnaire. Help you advocate for your symptoms with your gynecologist, based on your intake or connect you to a new center where their AI is being piloted and the clinical trial conducted.

3. Blood test / HerResolve

Kate had two small tubes of blood drawn for a test built by @Heranovalifesci.

The test measures seven biological markers (three microRNAs, three proteins, and one hormone) and uses an AI model to help detect endo.

It was highly accurate in its validation study at confirming endo and caught most cases that ultrasound and MRI had missed.

Their technology has been validated in a peer reviewed study (298 women, 11 sites across US/Europe/Hong Kong, published in the Journal of Minimally Invasive Gynecology): specificity 97.5%, sensitivity 80%, with strong diagnostic performance (94.4%), demonstrating it was highly effective at distinguishing women with endometriosis from those without the disease.

A positive result is a strong signal, since only 2.5% of women without endometriosis test positive, though final confirmation is still clinical. A negative is less conclusive, because the test misses about 20% of true cases.

The test identified 61.5% of histologically confirmed cases that transvaginal ultrasound and/or MRI missed.

#

We did one more saliva based test and will report back on that when results are returned.

[Cinna @blazyjai]

Everything is literally worse

[DRZUPREEME @DRZUPREEME]

Israel está invadiendo México activamente.

[sarzamora @shesssar]

me acuerdo que cuando se hicieron manifestaciones aquí sobre lo de Palestina mucha gente mamaba que “se preocuparan por lo que sucede en México y no al otro lado del mundo” y se burlaban de quien alzaba la voz, se les advirtió que terminarían con Gaza y vendrían aquí

[// @alemcnts]

@34thjesus el vato?

[Schmidt Ocean @SchmidtOcean]

For the "Awesomely Peculiar Hall of Fame" — extremely rare sighting of a barreleye fish & first footage of this species, Winteria telescopa, alive in situ. Filmed during the #Doldrums expedition at 710 m. Read more about tubular eyes & a light organ here: https://t.co/oqf0OT4mlr

[J🦑🌅 @SumerianEunuch]

I feel like we kinda let it get past us that we looked inside a cat's brain and saw that they see human faces as cat faces

[former funny girl @nehama_]

Jack Antonoff se ve cómo el carajo al que le das un chance porque parece que es un buen tipo y procede a destruirte emocionalmente a niveles apocalípticos, pero nunca admitirá que fue un mamaguevo porque se escuda en el arquetipo del good guy

[// @alemcnts]

estoy atrapada en los cigarros con fetos abortados y disfunción erectil

[𝓑𝓪𝓻𝓫𝓲𝓮 𝓢𝓸𝓹𝓻𝓪𝓷𝓸 @thiccbookthotty]

stop showing me your beautiful Asian cigarettes i am trapped in Canada

[yanoquierollorartodoeltiempo @sar4akahotgirl]

se nota cabrón que a ti no te criaron bajo la idea de que si le das a un hombre el poder de alimentarte también le estás dando el poder de matarte de hambre

[// @alemcnts]

@ranitaadejardin literal

[// @alemcnts]

@veebyblue si ya tienen su colonia en tonalá

[໋ @getocausa]

no es por ser conspiranoico pero creo que el mundial intenta que el mundo odie a latam para cuando los sionistas nos invadan por completo nadie nos ayude y crean que nos lo merecemos

[✿ vika alvarez °•*⁀➷ @museodesam]

Unpopular opinion tal vez pero, además del trend de “futbol para las girls 😋”, se me hace igual de estúpido el de “por supuesto que me iba mal en matemáticas….soy artista” ???? speak for urselves jdhdjdhdh

[ؘanitta ✦ @dandelioward]

que estamos esperando para sacar a Israel del país??? nos están privatizando del agua y nos están invadiendo poco a poco, tenemos que hacer algo antes de que sea demasiado tarde para nosotros

[mon (copycat killer version) 🛸 @crik0chu]

ya chicos ya pasó la fiebre mundialista ahora hay que concentrarnos en los putos judíos que nos están invadiendo

[Emily @sharp_objectt]

moving to china for flavored cigs

[val @untouchedXOXO]

Así como nos organizamos para celebrar, así hay que organizarnos para sacar a los pinches israel*s de méxico