Alexandre

R&D Scientist | Chemistry | Biotechnology | Nucleotides | Nucleobases | Nucleic Acids | he/him | All views my own

[Phys.org @physorg_com]

#Light-activated metal complexes can disrupt antibiotic resistance in #E.Coli by targeting resistance enzymes, significantly enhancing antibiotic effectiveness without harming human cells. @thecrick @J_A_C_S https://t.co/hEHejl0huT https://t.co/RrKSCDr5mm

[J. Am. Chem. Soc. @J_A_C_S]

Light-Activated Metal-Dependent Protein Degradation: A Heterobifunctional Ruthenium(II) Photosensitizer Targeting New Delhi Metallo-β-lactamase 1 | Journal of the American Chemical Society @KingsCollegeLon @TheCrick @Jeannine__Hess https://t.co/5myJNxnNNO

[Jeannine Hess @Jeannine__Hess]

We are thrilled to see this out! 🥳🍾Check out our work on light activated ruthenium complexes to degrade NDM-1 in Gram-negative bacteria! Wonderful team effort by the group!

[Jeannine Hess @Jeannine__Hess]

📣Fully-funded 4-Year PhD available in my lab! Join the team to shape the future of metal-based antibiotic drug discovery.

Application deadline 5th of November! Spread the word
#chemtwitter #RealTimeChem #PhDPosition

https://t.co/5SyA3dfuhG

[Jeannine Hess @Jeannine__Hess]

🚨preprint🚨
Read our new work on reactive metallo-scaffolds (r-mS)! We combine metal complexes with chemoproteomics to discover new liganding sites across the proteome! Shout out to a great collaboration with GSK! Fantastic team effort 🫶🏻https://t.co/uZUsXthRIU

[Jeannine Hess @Jeannine__Hess]

📣Preprint 📣
You want to degrade a protein in Gram-negatives? We have tackled this challenge! Detailed study of our Light-Activated Metal-Dependent Protein Degradation LAMP-D system in targeting and rescuing NDM-1 activity. What an amazing team effort 🫶🏻 https://t.co/hjjhphljjc

[Alexandre @alexandre__h]

Imagine a small molecule that degrades a target protein like PROTACs, but does so independently of any of the host cell's degradation machinery, so you can go and do targeted protein degradation in gram-negative bacteria: https://t.co/Xn76zFylpD

[Jeannine Hess @Jeannine__Hess]

🚨Less than a week left to apply (deadline 19/03/25) for this exciting fully funded 4 Year Phd position in my group.

Multidisciplinary project on the design of novel metallo-NBTIs including all the fun of chemistry and much more! Please RT!

Apply here: https://t.co/5SyA3deWs8

[Jeannine Hess @Jeannine__Hess]

PhD opportunity @TheCrick and @kclchemistry 🚨 Are you passionate about pushing research frontiers? This project offers the chance to develop cutting-edge skills across multiple disciplines. Application deadline 19th of March!!! Retweet appreciated 🫶🏻https://t.co/5SyA3deWs8

[ManuelMuellerLab @lab_mueller]

@Jeannine__Hess Exciting joint PhD project availble with @Jeannine__Hess at the interface of biomedicinal chemistry and chemical biology through @The_MRC DTP. https://t.co/XafQaNICFw…

[Jeannine Hess @Jeannine__Hess]

Exciting opportunity🚨 Joint PhD position with @lab_mueller 👇🏻Application deadline 29th October 24! https://t.co/7oI6Oa8NkV
Retweets much appreciated!

[Alexandre @alexandre__h]

Thanks @CambridgeIndy for publishing my view on closing the Mill Road Bridge for private vehicles.

[Max Gutierrez @maxgabgut]

https://t.co/sNhWf0K217

[Alexandre @alexandre__h]

"Prioritizing family life has earned me respect in my field — and my research has improved, too"

https://t.co/0MDfUuMAGR

[J. Am. Chem. Soc. @J_A_C_S]

Rapid Peptide Cyclization Inspired by the Modular Logic of Nonribosomal Peptide Synthetases | Journal of the American Chemical Society @KingsCollegeLon #Peptide #Cyclization #Modular #Logic #Nonribosomal #Synthetases https://t.co/y8KblJofsN

[King's Chemistry @kclchemistry]

Our scientists have discovered a rapid method of making cyclic peptides - an important class of antibiotic molecules! ⭕

🦠 The approach could speed up efforts to produce new antibiotics in the fight against #AntimicrobialResistance

Find out more 👇
https://t.co/XN5s09hIl5

[Synthesis Workshop @MatthewHorwitz1]

IT'S FINALLY HERE! Starting October 28th, the Synthesis Workshop Advanced Organic Chemistry course will begin releases through our regular YouTube channel for FREE, thanks to the massive efforts of presenters from many researchers from academia and industry!

Support by sharing!

[Jeannine Hess @Jeannine__Hess]

🚨🚨🚨Exciting opportunity to join our labs @impchemistry and @TheCrick and work on an exciting project! RT appreciated. #chemtwitter

[Jeannine Hess @Jeannine__Hess]

🚨🚨🚨 Exciting PhD opportunity to join Sasi Conte's lab and mine @KCLBMBioscience and @TheCrick on an adventure of identifying new RNA-protein inhibitors! Deadline 9th of November 🔔🔔 #chemjobs

RT highly appreciated!

https://t.co/Vo5oRi8GBL

[Alexandre @alexandre__h]

Structures-Who-Cannot-Be-Named and other wizardry in this paper ⬇️