Guada Alvarez

Fellow at UoN. Designing chromosomes, starting with yeast 🧫🔬Tech obsessed 🤩 🧪

[parm🔬 @parmita]

the future of biotech: a whitepill

Right now, we are feeding innovations to giant corporations who have the funds and ability to take them through to trials, manufacture them, and make them “theirs”. There’s no founder mode - all manager mode. This is because they have the work-hours, money, scale, and sometimes, connections, to make this happen.

In the future, we will be able to take an innovation and put it all the way through to market - as a startup. There will be fair competition, and it won’t happen alone.

-from CROs, we will go to robotic CROs - with code to control your experiment. Democratising and personalising your protocol will help add variety. Automation will add speed.

-we will move into recursive and intelligent drug discovery, and utilise automated and AI-driven precision manufacturing organizations for highly targeted chemicals.

-from CDMOs, we will go to fast programmable co-bot robots, lithography and 3D printing. Automation here will help bolster economies of scale without the added steps.

-for clinical trials, we will clean up our inefficient trial system, enrol in partnerships, and conduct smart experiment design, hopefully with the help of clinical trial facilitation-focused CROs

-we will have real startup cities for biotech, inspired by startups that decided to lead the revolution.

-we will have serious, real measurement techniques, compute, data, and algorithms to constantly iterate on our process.

-we will have the backing of a friendlier FDA, and the biotech stock markets will boom.

-instead of relying purely on big pharma, we will shake hands with big tech, which now has the ability to help us accelerate our efforts in all directions.

-real competition will kick in, allowing drugs to be priced more variably, patients to have a greater voice and choice, and the stock market to reflect the real, extreme importance of biotech.

[Sergey Ovchinnikov @sokrypton]

A few more letters... and we can finally write amino acid sequence with protein structure encoded by amino acid sequence? 🧬🤔😀

@chrisfrank662 @DominikSchiwie0 Lara Fuss @hendrik_dietz

https://t.co/DbYAujJRgS

[Dixon Lab @BiotechDixon]

Last publication from the @BiotechDixon Lab @UoMMIB lead by @AlgonGuada. https://t.co/F9Vwimr9zz #TPA #plastic

[Dixon Lab @BiotechDixon]

Congratulations to all involved- Characterisation of TphC, a bacterial transporter responsible for the cellular uptake of the PET plastic breakdown product TPA https://t.co/hNUk4bDbTH
@BiotechDixon @UoMMIB @SustainableUoM @UoM_MERI #pollution #plastic

[Guada Alvarez @AlgonGuada]

@CGEspManchester Muchas gracias! Y una vez registrada como puedo pedir cita para renovar mi pasaporte?

[Michael Krogh Jensen @MiKrogh]

Following @biorxivpreprint comments and peer-review I am happy to see the fruit of our collaboration between @tudelft and @DTUBiosustain on #biosensor-assisted control curcuits published: https://t.co/P9ng6koJSn. Congrats to all and thx to @novonordiskfond & @EU_H2020 for funding

[Pablo Carbonell @pablocarb]

Our new paper on biosensors and dynamic pathway regulation of cell factories is out in @iScience_CP ! Congratulations @Yadira32909360 @alejovigno @J_PicoMarco

[Marc Andreessen 🇺🇸 @pmarca]

https://t.co/IlRYdH6610

[Zibo Chen @ZiboChen]

Excited to share CIPHR 🖥️ -- logic gates constructed from scratch, using de novo designed proteins (1/5) https://t.co/Q9ojEXIO3T

[Ross Kent Ph.D. @rwk202]

Really excited to see @culturebiosci applying #ComputerAidedBiology This kind of tech will be essential to address tough challenges around scale-up in bio-manufacturing. Also a great resource for SynBio start ups #IoT #automation #synbio

[Guada Alvarez @AlgonGuada]

Very exciting new dual PhD programme between @OfficialUoM and @Tsinghua_Uni in synthetic and systems biology #Synbio

[Dixon Lab @BiotechDixon]

Please RT - New Dual PhD Programme between Manchester & Tsinghua Universities #SynBio #bioeconomy #generationUK ���@UoMMIB⁩ ⁦@UoMNews⁩ ⁦@cn_British⁩ ⁦@Tsinghua_Uni⁩ https://t.co/JSCN7bHe9Q

[Dixon Lab @BiotechDixon]

Biotech breakthrough turns waste biomass into high value chemicals https://t.co/WVcXIYVcPq @UoMMIB @Turner_Biocat @SYNBIOCHEM

[Angel Goñi-Moreno @angelgm.bsky.social @AngelGMoreno]

New paper out in @NatureComms with a brilliant list of co-authors! We propose the notion of #CellularSupremacy to focus attention on domains in which #biocomputing may offer superior performance over traditional computers. https://t.co/U5R8n4oa5Y

[SynbiCITE @SynbiCITE]

Prof Freemont, Co-Director @SynbiCITE, discusses data-driven design & the opportunities it presents for #biotech companies in a recent paper published in The Emerging Topics in Life Sciences https://t.co/2orGSDYF0r #synbio #data #engbio

[Ross Kent Ph.D. @rwk202]

Great new modular, orthogonal regulation tools from the Wilson lab.

This field is moving so fast that we published a review 2 days ago and it's already outdated.

https://t.co/5FDSrj3fw5

[Guada Alvarez @AlgonGuada]

Such a good and insightful review on modern tools for gene regulation. Very well done @rwk202 #synbio

[Ross Kent Ph.D. @rwk202]

Really excited to see a review I wrote with @BiotechDixon on the current state of the art tools for gene regulation in bacteria published for all to read. https://t.co/hURpqmGrI5

[Guada Alvarez @AlgonGuada]

@iGEM_Manchester Good luck guys!

[Ross Kent Ph.D. @rwk202]

New review out from @BiotechDixon @UoMMIB on biosensors for lignin bioprocessing and valorization. Great work @AlgonGuada #proudexiGEMsupervisor #SynBio

[Guada Alvarez @AlgonGuada]

@rwk202 @BiotechDixon @UoMMIB Thank you @rwk202 😍!!! #bestexiGEMsupervisor

[Guada Alvarez @AlgonGuada]

Very happy to see my review on biosensors for lignin valorization out now! @BiotechDixon https://t.co/AeLazQp6vz #synbio

[Dixon Lab @BiotechDixon]

Review out now “Genetically encoded biosensors for lignocellulose valorization” https://t.co/MwirtSngqp @UoMMIB