Ali Siddique

Architect. Pessimist . Dreamer.

IG aliasarchitect

[Massimo @Rainmaker1973]

Clinicians described the results as “one of the most amazing things I’ve ever seen.” An experimental once-daily oral drug called daraxonrasib has produced unprecedented outcomes in advanced pancreatic cancer, reducing the risk of death by 60% compared to standard chemotherapy.

In the Phase 3 RASolute 302 trial, daraxonrasib, a RAS(ON) multi-selective inhibitor developed by Revolution Medicines, nearly doubled median overall survival from 6.6–6.7 months with chemotherapy to 13.2 months in patients with previously treated metastatic pancreatic ductal adenocarcinoma. The trial, presented as a plenary session at the 2026 ASCO Annual Meeting, triggered a rare standing ovation from oncology experts.

Unlike traditional therapies, daraxonrasib effectively targets multiple KRAS variants and even wild-type RAS, offering broad applicability to the vast majority of pancreatic cancers. The drug was also far better tolerated, with only 1.2% of patients discontinuing treatment due to side effects, compared to 11.2% in the chemotherapy arm.

This represents a major advance for a disease long considered one of the most lethal in oncology. Experts are hailing daraxonrasib as a potential paradigm shift that could transform metastatic pancreatic cancer into a more manageable condition. The FDA has already granted expanded access for eligible patients.

[O’Reilly, E. M., et al. (2026). Daraxonrasib or Chemotherapy in Previously Treated Metastatic Pancreatic Cancer. New England Journal of Medicine. DOI: 10.1056/NEJMoa2605555]

[IT Unprofessional @it_unprofession]

Last month my intern asked for help with a Kubernetes error.

He was stuck on a YAML file.

He looked desperate.

I make $275,000 a year.

I haven't written a line of code since 2017.

I don't even know what a "pod" is.

But I didn't tell him that.

I leaned back in my Herman Miller chair.

I said, "Stop trying to code. Start prompting."

I told him to paste the error into ChatGPT.

He did.

The AI told him to delete the cluster.

He did.

Production went down instantly.

The CEO called me screaming.

I didn't panic.

I told the CEO we were "testing our disaster recovery protocols."

He was impressed by my foresight.

I got a bonus.

The intern got fired.

Innovation requires sacrifice.

Just not mine.

[Nature is Amazing ☘️ @AMAZlNGNATURE]

A polar bear was recorded having traveled 9 days straight without stopping!

[Megatron @Megatron_ron]

⚡BREAKING:

🇳🇴🇮🇱Norway at the trial in the ICJ went full Anti-Israel

Norway:

"Israel's actions in the OCCUPIED territories are a violation of international law"

“The apartheid wall is a violation of international law and makes the two-state solution difficult to achieve.

Gaza Strip and the West Bank are occupied territories regardless of any Israeli withdrawal.

The occupation remains temporary and cannot be continued or justified.

Israel violates international law and continues to violate it. Israel must abide by international law and provide the right to self-determination to the Palestinians.

Israel's actions in the occupied territories are a violation of international law.

It is not legal to annex any Palestinian lands or impose a fait accompli on the ground.

Establishing settlements in Palestinian territories violates Article 416 of the Geneva Convention.

Israel exploits natural resources to perpetuate its occupation of Palestinian territories.

Measures must be taken to prevent Israeli practices that violate international.”

https://t.co/0LWwK3vm7y

[Ali Siddique @aliasarchitect]

@MuhammadKhurram @LaurenWitzkeDE Source? This is nuts!!

[Lauren Witzke @LaurenWitzkeDE]

As a Christian, this just never sat right with me.

They kept calling us “Hamas Supporters” simply because we opposed the murder of a lot of innocent people.

Thousands and thousands of little children are now dead.

It has become extremely obvious that this is not about taking out Hamas, but instead it’s a pre-planned invasion designed to wipe out an entire people for a land grab.

You can’t tell me Jesus approves of a total slaughter, and you’re lying to yourself if you think He does.

[Ali Siddique @aliasarchitect]

‘Israel’s 75 years of war on Palestine is such a western way of coping’ ... https://t.co/gj5twl19kR via @YouTube

[sidra qasim @sidraqasim]

This is so tragic and horrific to witness. A father is kissing, hugging, and saying goodbye to his baby girl, her body wrapped in plastic and then in a white sheet, ready to be buried. And then you see that this man has actually lost two children, probably around the ages of 2 and 3. You think it's enough until you see another girl standing, pinching her fingers, watching all of this with a scared face and heavy breaths 😞

[Elon Musk @elonmusk]

The real fight is not between right and left, but rather between humanists and extinctionists

[Ali Siddique @aliasarchitect]

@FrontierCare was headed to MDW from ORD today, got multiple texts about delays and couldn’t check in for the past 2 days. Headed to the counter at 7pm for an 8:13pm flight due the delays. I was told I needed to be at the counter 60 min prior to the flight. couldn’t board.

[Elon Musk @elonmusk]

Extremely destructive if accurate

[The Kobeissi Letter @KobeissiLetter]

% of Income Used on Home Payments, by State:

1. California: 63%
2. Montana: 50%
3. Oregon: 49%
4. Washington: 49%
5. Idaho: 48%
6. Massachusetts: 46%
7. Colorado: 46%
8. Florida: 44%
9. Utah: 44%
10. New York: 43%
11. Nevada: 43%
12. Arizona: 43%
13. New Jersey: 43%
14. Rhode Island 42%
15. New Hampshire: 42%

We now have 30 states where residents are paying at least 30% of their annual income on home payments.

Meanwhile, mortgage demand is at a 30-year low and housing affordability is worse than 2008.

Buying a home has become a luxury.

[Ali Siddique @aliasarchitect]

@FAANews How frequently will updates be posted? I’m trying not to have to deplane here if possible. Also, this wouldn’t have anything to do with Ru….a would it?

[rabia O'chaudry @rabiasquared]

My statement on the news that all charges have been dropped against Adnan ❤️

[Ali Siddique @aliasarchitect]

@elliebirkinshaw Congrats

[laila dalton @lailaddaltonn]

Food-share bags that Starbucks supposedly donates found in a dumpster in Grand Prairie, Texas.

[Pieter Friedrich @FriedrichPieter]

Warning the Village of Glendale Heights (@VOGHNews) that their Congressman, Raja Krishnamoorthi, is linked to donors who helped elect #Modi, that Modi's #RSS regime is on the verge of genocide, & that @CongressmanRaja remains silent.

They tried shutting me down, but I persisted.

[michael @big_mikee88]

@lululemon 2014 quality

[Cliff Levy @cliffordlevy]

Horrific cases of sexual violence by Russian troops in Bucha and other places: a group of women and girls were imprisoned in a basement of a house for 25 days.
Nine of them are now pregnant, Ukraine’s ombudswoman for human rights said.
https://t.co/FYhGozkIHh

[Ali Siddique @aliasarchitect]

Leaving a legacy behind.

https://t.co/L4o4nOzEd5 https://t.co/poJIetCRFK