Andrew Gallimore

Tokyo. 作家. Neurobiologist, pharmacologist, writer on psychedelics, especially DMT. "Death by Astonishment", OUT NOW:

[Andrew Gallimore @alieninsect]

“His conclusions are astonishing…

And to some they will be horrifying.

This book is not to be missed."

— Dennis McKenna, PhD

DEATH BY ASTONISHMENT: Confronting the Mystery of the World’s Strangest Drug. (St. Martin’s Press, Macmillan).

OUT NOW

[Andrew Gallimore @alieninsect]

@MycoMinisterKY @RCarhartHarris But you’re right — there remains so much about the brain and psychedelics that we don’t know. But there’s also so much that we do. And much of that is thanks to Robin.

[Andrew Gallimore @alieninsect]

Next on the reading list (after Cormac’s bio) by @RCarhartHarris…

[Andrew Gallimore @alieninsect]

@MycoMinisterKY @RCarhartHarris “Exploring how psychedelics work” would be a terrible title.

Great for a high school textbook maybe.

[Andrew Gallimore @alieninsect]

@CodyArocho @RCarhartHarris Thank you! 🙏

(You’ll have to wait until Feb next year for Robin’s book though!)

[Andrew Gallimore @alieninsect]

https://t.co/qD8yVIGRe9

[Andrew Gallimore @alieninsect]

The first ever interview about DMT conducted entirely inside a hyperbaric chamber (AFAIK!!)...

With Alexander Tomic @Turulillo

Full 3-hour episode linked in reply...

[Andrew Gallimore @alieninsect]

@dmt_acc This is not DMTx. It’s a hyperbaric chamber.

[Andrew Gallimore @alieninsect]

“Don’t sell meth at the izakaya!”

[Andrew Gallimore @alieninsect]

@GallowglassPB @HamiltonMorris Thank you for gifting it to me! 🙏

[Andrew Gallimore @alieninsect]

Many thanks to @GallowglassPB for copies of this beautiful hardback edition of De Quincy’s classic, introduced by @HamiltonMorris…

Highly recommended! Get yours at link in reply! 👽

[Andrew Gallimore @alieninsect]

https://t.co/YP1FuXASyh

[Andrew Gallimore @alieninsect]

@0xbanal There she is…

[Andrew Gallimore @alieninsect]

@fuccboihermit2 Others would disagree:

[Captain Pleasure, Andrés Gómez Emilsson @algekalipso]

My answer is that DMT states of consciousness show clear computatipnal properties that are extraordinary.

In this video I cover how on DMT you may encounter entities that can color hyperbolic surfaces in extremely precise and quick ways, allow for topological transformations with non-trivial properties like turning sequences of experienced into tubes and then comparing them side by side, and identify topological extrema of shapes you have never seen before at sub-second speeds.

Essentially, on DMT you see really sophisticated examples of exotic qualia computing, which causes an immense impression of intelligence, agency, and information processing mastery.

https://t.co/IpejTJIxCT

[Andrew Gallimore @alieninsect]

Question for DMT People (and anyone else with insight/knowledge/training/etc):

After ingesting DMT, a recurring theme/impression is not merely the presence of "living entities", but of a profound unshakeable sense of their immense intelligence.

So, my question is: Based on your personal experience (or perhaps just your own insight/ideas), how is this impression of intelligence acquired?

Is it merely their technological/advanced appearance/environment/behaviour?

Is it the complexity of the beings or their environment?

Something else? Is it ineffable but somehow knowable?

So, in short, what gives you the impression that you're encountering beings that are not only living, but far more intelligent than us?

(P.S. I don't think this is a trivial question at all. Recognising intelligence in earthly creatures isn't trivial -- in discarnate entities even less so -- but I'd like ideas)

RT/tags/etc appreciated if you know someone who might have a good idea on this.

[Andrew Gallimore @alieninsect]

@FroodyBanana @zhonnymao There’s certainly no such assumption from my end.

[Andrew Gallimore @alieninsect]

@zero1one2three5 Yeah he says so in the title of the post.

[Andrew Gallimore @alieninsect]

Managing to get ripped off by FIVE different Kabukicho bars in one night for a total of 2 million Yen (close to $13,000) should come with some kind of award 🥇

[Andrew Gallimore @alieninsect]

@Danworldtour Slow-headed.

[Andrew Gallimore @alieninsect]

@dmt_quest Well, DMT is lipid soluble so much more likely to be involved with intracellular signalling. Did any of the recent Dean et al microdialysis studies look for 5-MeO?????

[Andrew Gallimore @alieninsect]

It's practically meaningless to compare absolute levels of DMT vs serotonin etc without considering the underlying receptor pharmacology. DMT has at least a 15-30x lower affinity for the 5HT2A receptor compared to serotonin, so even at comparable absolute levels its receptor occupancy is going to be very low.

I think DMT likely has an endogenous function, but more likely imo to be acute neuroprotection when levels are elevated dramatically under certain conditions (e.g. hypoxia) than some sort of constitutive effect on consciousness.

As regards it being a true neurotransmitter, the latest evidence contests that idea:
https://t.co/yrsQ2XRlYS

[Andrew Gallimore @alieninsect]

@PsychoMechanics Yeah I'm aware of all these bodily fluid studies but there have been quite a few studies now that measure endogenous DMT levels in the brain itself (albeit rodents). None, as far as I'm aware (but happy to be proved wrong) have detected 5-MeO-DMT.