๐ Age-associated gene expression changes were observed in non-neuronal cell types.
Most affected cells include immune cells (microglia and border-associated macrophages), oligodendrocytes, tanycytes (below in green), and ependymal cells.
https://t.co/KHgnNKBrAe
New brain aging study is out today in | @Nature
The largest single-cell RNA seq dataset of mouse brain aging reveals incredible insights and could pave the way for future therapies to slow or manage the impacts of the aging process. ๐งต #studyBRAIN
I'm excited to share our recent preprint, which investigates scRNA-seq and spatial transcriptomic analysis in Parkinsonโs disease patients from Korea. Working with human brain tissue has been invaluable, and I'm grateful for the contributors' valuable input in this study!
Single-nucleus and spatial transcriptomic analysis identified molecular features of neuronal heterogeneity and distinct glial responses in Parkinson's disease. https://t.co/lEXxgaOHQS #bioRxiv
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