Alissa Michel

Onc fellow @ColumbiaCancer. Graduate of @ColumbiaMedicine via @RWJMS '19 + @BostonCollege '14.

[Neil Vasan @NeilVasan]

2025 was a banner year for BC therapy across all subtypes. My take on the top practice changing trials:

1. DESTINY-Breast09 | ASCO 2025
1L HER2+ MBC: TDxD + P vs THP. Median PFS 40.7 vs 26.9 months; HR 0.56. Regimen FDA-approved.

2. lidERA | SABCS 2025
Adjuvant ER+ BC: Giredestrant vs standard ET. Improved iDFS, HR 0.70.

3. monarchE (OS update) | ESMO 2025
High-risk ER+ BC: Abema + ET vs ET improved OS; HR 0.84.

4. DESTINY-Breast05 | ESMO 2025
High-risk HER2+ BC with residual disease: TDxD vs T-DM1 improved iDFS.

5. NeoCARHP | ASCO 2025
Neoadjuvant HER2+ BC: Carbo-containing vs carbo-free chemo demonstrated noninferior pCR.

6. HER2CLIMB-05 | SABCS 2025
1L HER2+ MBC: Tucatinib + HP maintenance vs HP alone improved PFS

7. TROPION-Breast02 | ESMO 2025
1L PD-L1- mTNBC: Dato-DXd vs chemo improved OS (23.7 vs 18.7 mo, HR 0.79).

8. ASCENT-04 | ASCO 2025
1L PD-L1+ mTNBC: Saci + pembro vs chemo + pembro improved PFS.

9. ASCENT-03 | ESMO 2025
1L PD-L1- mTNBC: Saci vs chemo improved PFS.

10. VIKTORIA-1 | ESMO 2025
2L ER+ MBC, PIK3CA WT: Geda + palbo + fulv triplet and geda + fulv doublet vs fulv improved PFS.

11. SERENA-6 | ASCO 2025
1L ER+ MBC switch: ctDNA-detected ESR1 mut; switch to camizestrant + CDK4/6i improved PFS vs AI + CDK4/6i.

12. DESTINY-Breast11 | ESMO 2025
Neoadjuvant HER2+ BC: TDxD + THP vs ddAC/THP improved pCR.

@theNCI @SusanGKomen @METAvivor @BreastCancerOrg @LivingBeyondBC @BCRF @PIK3CApathbreak @NBCCStopBC @Perlmutter_CC #bcsm

[Alissa Michel @Amich1122]

Thank you so much for this honor @ConquerCancerFd ! #asco2024 #endcancer @DrDawnHershman @MAccordino @MichaelMayMD @MSHughes_MD @KristineLacuna @columbiacancer

[Dawn Hershman @DrDawnHershman]

So thrill to see our ⁦@columbiacancer⁩ ⁦@ColumbiaMed⁩ acknowledged ⁦@ASCO⁩ ⁦@ConquerCancerFd⁩ grants award ceremony 👏🙌🙏 congratulations to all 🎉

[Dawn Hershman @DrDawnHershman]

So thrill to see our ⁦@columbiacancer⁩ ⁦@ColumbiaMed⁩ acknowledged ⁦@ASCO⁩ ⁦@ConquerCancerFd⁩ grants award ceremony 👏🙌🙏 congratulations to all 🎉

[Dawn Hershman @DrDawnHershman]

Our @columbiacancer @ColumbiaMed #Breast_Team well represented @SABCSSanAntonio #SABCS23 - so thankful to work with this amazing crew 🙏❤️🙏

[Coco Gauff @CocoGauff]

Concrete jungle where dreams are made of…… @usopen

[Alissa Michel @Amich1122]

@NoahKahan NYC again!!! How about Beacon Theater?

[Herbert Irving Comprehensive Cancer Center @columbiacancer]

A beautiful view to start the week at @ColumbiaMed/@nyphospital. 😍

📷: @drmnstein

[Alexandria Ocasio-Cortez @AOC]

Daily reminder that Ticketmaster is a monopoly, it’s merger with LiveNation should never have been approved, and they need to be reigned in.

Break them up.

[Andy Slavitt 🇺🇦 @ASlavitt]

If airlines can ask us not to eat peanuts on board if there is someone with a peanut allergy, why won’t they ask us to wear a mask if there’s an unvaccinated 4 year old or cancer patient on board?

[sandra 🤠 @sandra32gonza]

The dmv be like you forgot to bring the Declaration of Independence

[alex @alex_abads]

not New York City sending me an emergency alert telling me to turn off my ac when Times Square is lit up like she is

[Craig Spencer MD MPH @Craig_A_Spencer]

115,000 healthcare workers have died of Covid.

As the pandemic rages across the globe, the overwhelming majority of my healthcare colleagues around the world haven’t yet had access to a vaccine, while wealthy countries like the US are sitting on a massive pile of surplus doses.

[Stella Safo, MD MPH @AmmahStarr]

Gianna Floyd still goes to bed tonight without her father.

None of this will undo that reality.

[Alissa Michel @Amich1122]

@MandyPx123 Even multigrain 😋

[Karine Jean-Pierre Archived @PressSec46]

"Finding light in the darkness is a very American thing to do. In fact, it may be the most American thing we do." @POTUS

[Relatable Resident @relatableafmd]

Sorry I’ve been quiet my current schedule is wake up, go to work. keep people alive for 13 hours, go home, research expensive candles and fantasize about what they smell like, sleep, repeat

[Natalie Montelongo @natimontelongo]

You can’t honor our frontline workers, while also fill a stadium with 25,000 people.