Together with UC Berkeley we are announcing the laser phase plate - a breakthrough in atomic resolution imaging. This is the brightest continuous wave laser in the world, 100 million times the intensity of the surface of the sun.
Phase contrast plays an important role in microscopy, but it was thought close to impossible for electron microscopy, where it would require interfering with an electron beam. Holger Mueller and Robert Glaeser proposed exactly this using a standing wave laser. It has taken over 15 years to make this a reality. Biohub partnered with UC Berkeley and Mueller to support this work and to engineer and build the technology.
Contrast has been the critical barrier to achieving atomic resolution imaging of the cell. In cryo-electron tomography, a cellular imaging technology that uses electron microscopy, the low contrast makes it impossible to resolve anything but the largest proteins within their cellular context. The laser phase plate removes that barrier.
With advances in AI this breakthrough in contrast will start to open up a new frontier in structural biology, that will allow us to see the molecular machines of the cell, and how they assemble into far more complex and dynamic systems, and understand how they work.
This election cycle was the toughest for BJP. It came between BH and UP elections.
Assam was Gogoi’s.
WB was left or TMC.
TN was Amma or Karunanidi.
KL was LDF of UDF
BJP was a non player in this cycle.
And here we are today. 15yrs later!
Early in my DevOps career, I deleted a 5GB log file from a production server that was running out of space.
I ran df -h expecting to see the disk usage drop. It didn’t.
Still showed 100% full.
No errors, no warnings. Just the same disk usage as before I deleted anything.
That’s when I learned that deleting a file doesn’t always free up space immediately.
In Linux, what we think of as a “file” is actually two separate things: the filename (which is just a pointer) and the inode (which contains the actual data and metadata). When you delete a filename, you’re only removing the pointer. The inode and its data remain on disk as long as any process still has the file open.
In my case, the web server was still writing to that log file. Even though I had deleted the filename, the server process kept its file handle open. The inode stayed alive, invisible to normal file listings but still consuming disk space.
The space was only freed when I restarted the web server, which closed all its file handles.
This is why you need different commands to see the full picture:
# Check filesystem usage
- df -h
# Check actual directory sizes
- du -sh /var/log/*
# Find deleted files still open by processes
- lsof +L1
The du command shows you what’s actually using space in directories, while df shows filesystem-level usage.
When they don’t match, you often have deleted files still held open by running processes.
This is also why proper log rotation doesn’t just delete files. Tools like logrotate rename files and send signals to processes so they can close and reopen their file handles cleanly.
Three key takeaways:
1. Filenames are just pointers to inodes
1. Deletion only happens when no processes reference the inode
1. Always check both df and du when troubleshooting disk space
It’s a small detail, but understanding it can save you from confusing production incidents.
At my first job we used to run a small 3 node kafka cluster on EC2s processing over 10B msgs daily. The whole setup costed us total of 5000$/yr.
In 5 years we spent less than 48 hours in total on maintenance and upgrades with zero downtime.
Confluent quoted 150k yearly.
til some folks nowadays consider running a normal linux web server like we've all done for decades to be a "non-standard stack"
feels like some kind of learned helplessness or something
🚀 We're hiring EMs, SDE3 and SDE2! 🚀
Healthcare shouldn’t be a mystery. Your lab reports, prescriptions, and vitals should be understandable, actionable, and work for you.
That’s what we’re building at Health Records & Insights—a personal AI-powered health system.
🔗Apply👇🏼
🔥 I'm a Firefighter! The first responder, always ready to tackle production fires and keep systems running smoothly.
What's your DevOps personality?
#DevOpsPersonality#EngineeringLife#DevOpsBingo#Kapstan https://t.co/df4KvbKyiT
Here is an idea to put all the EVM manipulation debate to rest.
@ECISVEEP should publish voting data with timestamp for all machines online(masked obv)
Let independent analysts verify patterns & spot irregularities themselves. Transparency builds trust #MaharashtraElection2024
When and why did we as Indians accepted that having a bad drainage system is completely normal in the modern society?
It impacts every class of people, then why there's no outrage around cities getting flooded after every rainfall.
I am sure it's not rocket science.
For everyone who answered the surveys, thank you so much. Presenting the first version of our redesigned Health Records.
Beta starts rolling out today.
If you have more suggestions, features that you as a user would want; please let me know. I’d love to help you be healthier!
Disable all transactions on your Axis card immediately!!
I had an international transaction attempted on my Magnus Card for 50₹ but failed because I had already disable it. Looks like a breach from some third party
Something is VERY WRONG at @AxisBank credit card.
One of my cards was used for a fraudulent txn at Uber Eats Canada.
Card was reissued - suddenly fraudulent txns on new card WHICH I DONT HAVE YET.
Investigation SAK 0000 233 6061 raised at Axis Bank. They REFUSED to investigate.
📢 "The One Billion Row Challenge"
How fast can YOU aggregate 1B rows using modern #Java? Grab your threads, flex your SIMD, and kick off 2024 true coder style by joining this friendly little competition. Submissions accepted until Jan 31.
👉 https://t.co/qIYfqb1ugF
Continuing on my previous post, I have tried to explain the challenges of Ingesting data from IoT devices at Loconav.
I have tried to keep things simple but might have lapsed a bit, let me know if you any feedback or questions around it. Happy Reading (:
https://t.co/CqO4zXQgK1