Antonio Lentini

Wallenberg & SciLifeLab DDLS fellow precision medicine. Assistant Professor Linköping University. Comp bio, single-cell omics, tumour evolution.

[Antonio Lentini @antle718]

A lot of hard work has gone into making this robust and reliable, must read for anyone working with RNA. Amazing effort by @JCMolBio @BReinius and our team.

[Björn Reinius @BReinius]

Excited to have published our work on #SEQURNA, a next-generation RNase inhibitor transforming #scRNAseq & other applications.

➡️Introducing synthetic thermostable RNase inhibitors to single-cell RNA-seq 🚀 🌕
https://t.co/qfCNvXm8Kk

🧵…

[Sequrna @sequrna]

Coming Soon!

#SEQURNA™ introduces #SEQblock™ tube modules.

Temperature uniformity and cleaner tube handling for your RNA workflows. Launching soon in 96-PCR, 384-PCR, 24-MCT, 48/12-PCR/MCT, & 15-MCT midi format.

Tell us what formats & features you seek!

[Sequrna @sequrna]

#SEQURNA Synthetic Thermostable RNase Inhibitor for #scRNAseq protects RNA at high temperatures, enabling new protocols. Dry-ice-free shipping improves #RNAseq sustainability🍀 R&D by @BReinius @sandberglab @JCMolBio @antle718 🌐 https://t.co/ATaSEbZqmt 🧬 https://t.co/KzA3Be2IeY

[Andrew Kern @pastramimachine]

Octopus Z dosage compensation!
https://t.co/HPlP6hVSPT

[Antonio Lentini @antle718]

Great work @nataliepapanic!

[Björn Reinius @BReinius]

Work spearheaded by PhD candidate Natalie Papanicolaou (@nataliepapanic). Check it out: https://t.co/rwq5BXXqgv #Xist #RNA #chromosome #XCI

[Björn Reinius @BReinius]

Thrilled about the launch of #SEQURNA RNase Inhibitor Thermostable in Genovis' new Genomics Branch, boosting RNA-seq with superior stability & sustainability. Discover more and join @GENOVIS in Advancing Next-Gen Genomics Tools! 🌟🔬 https://t.co/tofmyRYa41

[JCMolBio @JCMolBio]

We have rigorously tested the next-generation of RNase inhibitors - thermostable, robust, and resistant to batch effects - for single cell RNA sequencing and I am so excited that this pre-print is finally out! There is more information at https://t.co/Ej6HI8jrbg

[Ioanna Smyrlaki @IoannaSmyrlaki]

Our paper on Notch signalling pathway activation by soluble and multivalent Jag1 DNA origami nanopatterns is out at @NatureComms @bjorn_hogberg @teixeiralabki @vcluca1 https://t.co/98dny5c2RI

[Antonio Lentini @antle718]

Introducing the next generation of RNase inhibitors in scRNA-seq!

🔥 Thermostable
⏱️ Improved performance
🌿 Environmentally friendly

Happy to share our work at SEQURNA AB in this preprint showcasing the technology. Huge thanks to team and beta testers.

https://t.co/k8iAeUwbFs

[Daniela Calvigioni @Daniela_CalvG]

Today out @NatureNeuro Estrogen sensitive neurons control stress sensitivity in females and aversive state. What a beautiful journey, together @fuzikjanos @Pierre_Le_Merre @meletislab @CarlenLab. So proud of this work! #CuriosityDrivenScience https://t.co/dBxYGcLjyp

[Antonio Lentini @antle718]

Work funded by @ssmfgrants, @KAWstiftelsen, @Vetenskapsradet and @karolinskainst.

[Antonio Lentini @antle718]

What can we infer from equations with 2 unknowns? We explore this for concurrent X-chromosome upregulation/inactivation, raising doubts on recent findings that X-upregulation is limited to a few genes and driven by BRD4. With @BReinius.

https://t.co/nRXArc6JUm

[Antonio Lentini @antle718]

Also see news article from @karolinskainst:

https://t.co/DdpRP5y0Iy

[Antonio Lentini @antle718]

Check out our latest work on #Omicron variants featured on the cover of @MedCellPress.

With ABC Labs and @BReinius (who also made the cover).

Research made possible thanks to @KAWstiftelsen, @scilifelab, @stiftelse, @Vetenskapsradet.

https://t.co/rOYSdgtIaH

[Eric Topol @EricTopol]

New @MedCellPress
From ~175,000 samples in Sweden, a 2-fold higher viral RNA levels in upper airway for BA.2 relative to BA.1 cases, that helps explain its heightened transmissibility
https://t.co/RoTaRLKYYz by @BReinius and colleagues
(would be good to see such data for BA.5)

[Björn Reinius @BReinius]

"Monitoring of the SARS-CoV-2 Omicron BA.1/BA.2 lineage transition in the Swedish population reveals increased viral RNA levels in BA.2 cases" in @MedCellPress with @antle718. https://t.co/b2zfzFbA4W Research made possible by @KAWstiftelsen @scilifelab @stiftelse @Vetenskapsradet

[Karolinska Institutet @karolinskainst]

A KI study in @MedCellPress by @breinius and @antle718 presents a refined #COVID-19 test used to track the spread of #Omicron in real time.
https://t.co/bW3FeBQaCB

[Christoph Ziegenhain @chris_zie]

So excited to see our ✨🧬'Molecular spikes'🧬✨ RNA spike-ins out in @naturemethods 📃 Since the preprint, we have completely overhauled the design & produced a completely new expanded set of spikes, so check it out: https://t.co/dd7pyQV28J
more below...⬇️

[Alon Keinan @AlonKeinan]

Elastic dosage compensation by X-chromosome upregulation, by @antle718 et al. w/@BReinius from @karolinskainst

Another fascinating chapter on #ChrX #DosageCompensation

@NatureComms #OpenAccess
https://t.co/paTEYc2EvW

[Nature Communications @NatureComms]

Elastic dosage compensation by X-chromosome upregulation
https://t.co/vYDtr0wEzJ
@antle718 @BReinius @karolinskainst @KAWstiftelsen @ssmfgrants #DosageCompensation #Xinactivation #Xupregulation #scRNAseq