Excited to share the publication of my PhD work. We report the involvement of an R-loop helicase, Senataxin, in the restart of R-loop-stalled replication forks. Check it out here: https://t.co/Xe0QvVZRIY
@NAR_Open
1/9 Thread about harrasment by a #Fraud@careinsuranceIN company. #BEWARE
My father suffered from a heart attack a week ago. He never had a history of heart disease ever. This was the very first incident. We had taken a health insurance policy from this company on October 2023
Mission Gaganyaan
TV D1 Test Flight is accomplished.
Crew Escape System performed as intended.
Mission Gaganyaan gets off on a successful note.
@DRDO_India@indiannavy#Gaganyaan
Novel predators! "Kaonashia insperata gen. et sp. nov., a eukaryotrophic #flagellate, represents a novel major lineage of heterotrophic #stramenopiles". West et al. DOI 10.1111/jeu.13003
Something you have to learn to accept about biology (and can be challenging to folks coming from more quantitative backgrounds) is that even the most foundational questions have no simple answer, except for "it depends"
This is a great example
Chandrayaan-3 Mission:
'India🇮🇳,
I reached my destination
and you too!'
: Chandrayaan-3
Chandrayaan-3 has successfully
soft-landed on the moon 🌖!.
Congratulations, India🇮🇳!
#Chandrayaan_3#Ch3
TransitID is out today in Cell! This is a proximity labeling method for unbiased discovery of endogenous proteins that traffick from a defined “source” location to a defined “destination” location. TransitID uses sequential labeling by TurboID in the source, followed by a chase period (minutes to hours) and then 1-minute APEX tagging in the destination compartment. Proteins tagged by both enzymes are enriched with streptavidin and anti-fluorescein antibody, and identified by mass spec.
We explore 4 intracellular and intercellular applications of TransitID:
- discovery of locally translated mitochondrial proteins (translated at OMM, then imported into mito matrix)
- mapping proteins whose cytoplasm-to-nucleus shuttling is dampened by stress
- discovery of proteins that transit between nucleolus & stress granules during stress & stress recovery
- analysis of proteins that traffic intercellularly bw tumor cells & macrophages
Work of amazingly talented co-first authors @WeiQinChemBio and @CheahJoleen, and collaborators Steve Carr @namude & Paul Taylor
https://t.co/yo4laOA14z
BREAKING NEWS:
The 2022 #NobelPrize in Physiology or Medicine has been awarded to Svante Pääbo “for his discoveries concerning the genomes of extinct hominins and human evolution.”
If someone had gone to the Supreme Court against #TheKashmirFiles, would the Supremes have held the makers, and worse, Kashmiri Pandits, responsible for the "situation in the country"? Cc @vivekagnihotri