Some days remind you why we do this. Our patients’ courage never ceases to inspire. Honored to give a survivor medal to a brave patient—2 years post-ASCT for MCL (image posted with permission) @BaptistHealthSF
Very productive @FLASCO_ORG Business of Oncology Summit yesterday. It was a pleasure to participate alongside such an outstanding faculty group.
Don’t miss the education sessions at the Spring Congress—now underway.
Registration is open for the Miami Cancer Institute Immunotherapies Summit for Hematologic Malignancies 🗓️ Mar 6–7, 2026 https://t.co/yYslUdt10D
#HemeOnc#CART#AML#Lymphoma#MultipleMyeloma
Great MRD in AML session #Tandem26 Loved the practical insights from Dr Nadia Bambace and @SagheerTiba Lots of takeaways for real world practice. Privileged to work with them @BaptistHealthSF
Outpatient Administration of Bispecific Antibody Therapy for Hematologic Malignancies: A Practical Guide. Co-authored by @DholariaMD.
Read the full article. https://t.co/lxv84tYNIG
@Dr_AmerZeidan@ASH_hematology 2020 was my first ASH (virtual) and then in 2021 got my first in person poster photo (could not find the unmasked version)
Phase 1b double-dose axi-cel presented by Caroline Lee (Stanford). High response rates with axi-cel 2, greater CAR AUC with less exhausted phenotypes and low added toxicity. Excellent talk!
CAR-T in PCNSL #lymsm
- 67 pts, 25% CSF+, 12% eye+
- 57% axicel, 30% tisacel
- 58% CR, 1-yr PFS 50%, 1-yr OS 66%
- 2-yr RFS better if CR/PR at CAR infusion: 56% vs 28%
- 27% G3+ ICANS!
Almost all got bridging; would love to know which agents.
https://t.co/b09lNb884E
But perhaps the BIGGEST change that will affect my interpretation of trials is new neutropenia cutoffs!
v5 = Gr1 is LLN to 1500, Gr2 is 1000-1500, Gr3 is 500-1000, Gr4 is <500...
Now in v6 = Gr1 is 1000-1500, Gr2 is 500-1000, Gr3 is 100-500, Gr4 is <100!!!
I was lucky to lead this @CIBMTR analysis just published in @AjHematology 👇
https://t.co/5JtisXr3Tz
🔑 findings:
💡 CD19 CAR T-cell therapy leads to high rates of durable responses in patients with primary mediastinal large B-cell lymphoma (PMBCL): ORR 79% CRR 68% 2-year PFS 58.6%. Outcomes may be superior compared to other LBCL subtypes.
💡We observed significantly lower relapse rates in patients exposed to immune checkpoint inhibitors prior to CAR T-cell therapy with ~50% absolute reduction in relapse incidence in ICI-exposed (2-year cumulative incidence of relapse: 21.7%) compared to ICI-naive patients (41.6%).
💡Prior ICI exposure was not associated with higher rates or severity of early toxicities such as cytokine release syndrome and neurotoxicity.
❓More data needed to better characterize how ICIs impact CAR T-cell function and TME in patients with PMBCL
🙏All collaborators and co-authors @mshadman@fredhutch@NatalieGroverMD@BradHaverkos@DrMarcosdelima@AMalone2012@LauriePearsonMD@AnnaSureda5@Kwudhikarn@samyamshon + others not on X.
Special thanks to @MediHumdani@MedicalCollege and Senior Author Dr. Alex Herrera @cityofhope for their guidance and for putting up with me! 😅
👉Please share with your network if you learnt something with this post 🙏
#HemOnc #MedEd #lymphomasm #CARTcelltherapy
I am thrilled to announce my promotion to Medical Director of Cellular Therapy. It has been an amazing 4 years since I joined @BaptistHealthSF. I am looking forward to continue developing the Miami Cancer Institute adoptive cell therapy program with our amazing team and leaders.