Arghya Deb

Senior Scientist, Oligonucleotides & MedChem @StokeTx
Postdoctal Fellow @ChoudharyLab @PeterZhang_BC
PhD @maiti_iitb @iitbombay

[Department of Chemistry, IIT Bombay @Chemistry_IITB]

🧬Dr. Arghya Deb (alumnus Chemistry dept. @dm_lab ) presented “Proteolysis Targeting Chimeras (PROTACs) with Reduced Off-target” — exploring how rational design tweaks can preserve target degradation while minimizing collateral protein loss. @GSC_2025 @iitbombay @ruchianand1975

[J. Am. Chem. Soc. @J_A_C_S]

Asymmetric C–H Amination via Fe(III)-Metalloradical Catalysis Featuring α-Fe(IV)-Aminyl Radicals as Key Intermediates | Journal of the American Chemical Society @ChemistryBC @BostonCollege https://t.co/07n2BP20sN

[Arghya Deb @ArghyaDeb16]

@ChinmoyKHazra1 @rimasamanta61 @ANRFIndia @CSIR_IND @Chemistry_iitd Congratulations..looking forward to the chiral version

[Arghya Deb @ArghyaDeb16]

It was our @shamayeetaray great pleasure to host you.

[Debabrata Maiti @maiti_iitb]

It was a wonderful time meeting with original BoJ’s of @DM_Lab @SohamMaity03, @atmodak, @ArghyaDeb16, along with friends and family members of @DM_Lab, @mi_nishi4, @Soumyar18246839

Thank you all for making it so special.  Here is to your good health and happiness 🥂

[David R. Liu @davidrliu]

To evolve binding to PT-179, we attempted 96 in-parallel evolutions using PT-179 and different IMiD derivatives. Evolution on these “stepping-stone” compounds identified variants with detectable engagement of PT-179•CRBN at high concentrations of PT-179.
6/13

[David R. Liu @davidrliu]

Today in @Science_Magazine we report the laboratory evolution of compact degrons that enable targeted protein degradation triggered by an otherwise-inert small molecule, a multidisciplinary study that integrates organic chemistry, molecular glues, protein evolution, genome editing, and structural biology.
PDF: https://t.co/cCVLKL0w8Y
1/13

[Sreekanth Vedagopuram @Sreekanth_Vedas]

Excited to share our new article https://t.co/nPBKjDyccN published in @NatureChemistry
This article describes methods to identify off-targets of PROTACs and how to design cleaner PROTACs. @ ChoudharyLab @ TuanMNguyen @Sreekanth_Vedas @ArghyaDeb16 @kokkonda2

[Arghya Deb @ArghyaDeb16]

It was great to be part of such a wonderful team. Thanks and congratulations to @PeterZhang_BC and all the authors.

[Peter Zhang @PeterZhang_BC]

We reveal @Chem_CP a new mode of asymmetric induction in homolytic radical chemistry that involves a radical intermediate bearing kinetically stable chiral radical center. https://t.co/HCfb5Kbonq #MetalloradicalCatalysis

[Arghya Deb @ArghyaDeb16]

@maiti_iitb @CSIR_IND @AtBiju @KarlinLab @BuchwildGroup @iitbombay @dm_lab Many Congratulations Sir for your long awaiting and remarkable recognitions. 👏

[Arghya Deb @ArghyaDeb16]

Excellent news. Many Congratulations to my mentor @maiti_iitb

[DM Lab IIT Bombay @dm_lab]

Heartiest congratulations @maiti_iitb on being honored with the prestigious #SSB2022🤩.Your unwavering commitment to excellence and tireless efforts for outstanding contribution undoubtedly set a remarkable example. @dm_lab is proud to have you as a shining beacon in academia.💐

[Arghya Deb @ArghyaDeb16]

@filippo_romiti @J_A_C_S @LarisaPop737 @ZurwaCheema @LucaSan01410777 @UTDallasChemBio Congratulations.

[Shamayeeta Ray @shamayeetaray]

#latepost..Happy to share our review: https://t.co/x1NKMzi3xT, recently published in 'Biochemical Society Transactions' where we discuss how coordination chemistry of metal-bound structures of iron and manganese transporters correlate to their affinity and substrate selectivity.

[Arghya Deb @ArghyaDeb16]

Delighted to share the article. Thanks to @ChoudharyLab for making me a part of this journey.

[The Amit Choudhary Lab @ChoudharyLab]

In @ACSCentSci, we report two chimeric molecule platforms to induce tyrosine phosphorylation, a critical PTM. Chimeras (formed by fusing target and kinase binders) force kinase to phosphorylate non-substrate via induced proximity
https://t.co/CaWUPNYlqY

[Raghu @IndiaTales7]

India’s 8 Biggest Railway Stations with Highest Number of Platforms.

1. Howrah Railway Station, West Bengal – 23 Platforms

[Arghya Deb @ArghyaDeb16]

@AChemSynBio @SinghaSoumya Congratulations

[Arghya Deb @ArghyaDeb16]

@Debasis81025932 @ChemCommun @serbonline Congratulations!

[Arghya Deb @ArghyaDeb16]

@VictorKiryak Olefin metathesis with 1-butene

[MCB_Harvard @MCB_Harvard]

Multiple New X-ray Snapshots Reveal How Transition Metals Cross Cellular Membranes Through Nramp Transporters [Gaudet Lab] @RachelleGaudet @shamayeetaray @SamPinzkaBerry @eLife https://t.co/wfpW6osvLO

[Arghya Deb @ArghyaDeb16]

@dm_lab @BTrishatweets @soumyas007 Congratulations..now welcome to DM Alumni group

[JoVE @JoVEJournal]

Want to connect with JoVE Guest Editor Dr. Shamayeeta Ray of @Harvard and contribute to her collection of methods for membrane protein expression and purification?

Learn more and contribute today: https://t.co/pWiTpHGSwM

@shamayeetaray #Biochemistry